Effect of oral glucose administration on pain in neonates undergoing peripheral blood collection
Keywords:
pain, glucose, neonates, blood sample
Abstract
Background Peripheral blood sampling with heel sticks in neonatescould represent minor invasive procedure which generates pain.
The oral glucose administration can reduce the pain in neonates
during this procedure.
Objective To compare the pain sense after oral glucose
administration or placebo during peripheral blood sampling with
heel sticks in neonates.
Methods A double blind randomized clinical trial study was
conducted from January to March 2004 in three teaching hospitals
in Medan. The population of this study was divided into two
groups (glucose and placebo) and each group consisted of 32
neonates. The intervention group got 1 ml of 40% glucose and
the placebo group got 1 ml of sterile water. Blood sample was
taken with sterile hemolet with heel sticks from healthy aterm
neonates. The pain was measured using NIPS score and measured
in first 30 seconds after heel sticking. The heart and respiratory
rate measurement was done before and during the intervention
and we also counted crying time. Data were analyzed with student
t–test.
Results The significant mean difference of NIPS score in glucose
group was 2.22 (SD 0.83) vs 4.72 (SD 0.96) in placebo group
(P<0.0001). There was significant mean difference of crying time,
i.e. 0.16 (SD 0.37) in glucose group vs 2.05 (SD 0.77) in placebo
group (P<0.0001). There was significant differences of heart rate
before and during heel sticking in both groups.
Conclusion There were some differences of pain sense in neonates
who received 40% glucose compared to those who received sterile
water during peripheral blood sampling.
References
1. Gradin M, Eriksson M, Holmqvist G, Holstein A, Schollin J.
Pain reduction at venipuncture in newborns: oral glucose com-
pared with local anesthetic cream. Pediatrics 2002;110:1053-7.
2. Carbajal R, Veerapen S, Couderc S, Jugie M, Ville Y. Anal-
gesic effect of breast feeding in term neonates: randomized
controlled trial. BMJ 2003;326:1-5.
3. Shah VS, Taddio A, Bennett S, Speidel BD. Neonatal pain
response to heel stick vs venepuncture for routine blood sam-
pling. Arch Dis Child 1997;77:143-4.
4. Anand KJS, Phil D, Hickey PR. Pain and its effects in the
human neonate and fetus. N Engl J Med 1987;19:1321-9.
5. Johnston CC, Fillion F, Snider L. Routine sucrose analgesia
during the first week of life in neonates younger than 31
weeks postconcepional age. Pediatrics 2002;110:523-8.
6. Gomella TL. Heelstick (capillary blood sampling). In:
Gomela TL, Cunningham MD, Eyal FG, Zenk KE, editors.
Neonatology management procedures, on-call problems,
disease, and drug. 5 th ed. New York: Mc Graw-Hill; 2004.
p.182-3.
7. Anand KJS, Phil D. International Evidence Based Group for
Neonatal Pain: Consensus statement for the prevention and
management of pain in the newborn. Arch Pediatr Adolesc
Med 2001;155:173-80.
8. Jatana LCS, Dalal SLS, Wilson CCG. Analgesic effect of oral
glucose in neonates. MJAFI 2003;59:100-4.
9. Ramenghi LA, Evans DJ, Lavene MI. Sucrose analgesia:
absorptive mechanism or taste perception. Arch Dis Child
Fetal Neonatal 1999;80:146-7.
10. Carbajal R, Chauvet X, Couder S, Martin Mo. Randomized
trial of analgesic effects of sucrose, glucose, and pacifiers in
term neonates. BMJ 1999;319:1393-7.
11. Carbajal R, Lenclen R, Gajdos V, Jugie M, Paupe A. Cross-
over trial of analgesic efficacy of glucose and pacifier in
very preterm neonates during subcutaneous injections. Pe-
diatrics 2002;110:389-93.
12. Bauer K, Ketteler, Hellwig M, Laurenz M, Versmold H.
Oral glucose before venepuncture relieves neonates of pain,
but stress is still evidenced by increase in oxygen consumption,
energy expenditure, and heart rate. Pediatric Research
2004;55:695-700.
Pain reduction at venipuncture in newborns: oral glucose com-
pared with local anesthetic cream. Pediatrics 2002;110:1053-7.
2. Carbajal R, Veerapen S, Couderc S, Jugie M, Ville Y. Anal-
gesic effect of breast feeding in term neonates: randomized
controlled trial. BMJ 2003;326:1-5.
3. Shah VS, Taddio A, Bennett S, Speidel BD. Neonatal pain
response to heel stick vs venepuncture for routine blood sam-
pling. Arch Dis Child 1997;77:143-4.
4. Anand KJS, Phil D, Hickey PR. Pain and its effects in the
human neonate and fetus. N Engl J Med 1987;19:1321-9.
5. Johnston CC, Fillion F, Snider L. Routine sucrose analgesia
during the first week of life in neonates younger than 31
weeks postconcepional age. Pediatrics 2002;110:523-8.
6. Gomella TL. Heelstick (capillary blood sampling). In:
Gomela TL, Cunningham MD, Eyal FG, Zenk KE, editors.
Neonatology management procedures, on-call problems,
disease, and drug. 5 th ed. New York: Mc Graw-Hill; 2004.
p.182-3.
7. Anand KJS, Phil D. International Evidence Based Group for
Neonatal Pain: Consensus statement for the prevention and
management of pain in the newborn. Arch Pediatr Adolesc
Med 2001;155:173-80.
8. Jatana LCS, Dalal SLS, Wilson CCG. Analgesic effect of oral
glucose in neonates. MJAFI 2003;59:100-4.
9. Ramenghi LA, Evans DJ, Lavene MI. Sucrose analgesia:
absorptive mechanism or taste perception. Arch Dis Child
Fetal Neonatal 1999;80:146-7.
10. Carbajal R, Chauvet X, Couder S, Martin Mo. Randomized
trial of analgesic effects of sucrose, glucose, and pacifiers in
term neonates. BMJ 1999;319:1393-7.
11. Carbajal R, Lenclen R, Gajdos V, Jugie M, Paupe A. Cross-
over trial of analgesic efficacy of glucose and pacifier in
very preterm neonates during subcutaneous injections. Pe-
diatrics 2002;110:389-93.
12. Bauer K, Ketteler, Hellwig M, Laurenz M, Versmold H.
Oral glucose before venepuncture relieves neonates of pain,
but stress is still evidenced by increase in oxygen consumption,
energy expenditure, and heart rate. Pediatric Research
2004;55:695-700.
Published
2007-08-31
How to Cite
1.
Triani E, Lubis M, Yoel C. Effect of oral glucose administration on pain in neonates undergoing peripheral blood collection. PI [Internet]. 31Aug.2007 [cited 24Nov.2024];47(4):185-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/411
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Received 2016-08-31
Accepted 2016-08-31
Published 2007-08-31
Accepted 2016-08-31
Published 2007-08-31
