Treatment of ulcerated hemangiomas with propranolol: an evidence-based case report

  • Stefanus Gunawan Department of Child Health, Sam Ratulangi UniversityMedical School/Prof. DR. R. D. Kandoll Hospital, Manado
  • Yuri Yuri Department of Child Health, Sam Ratulangi UniversityMedical School/Prof. DR. R. D. Kandoll Hospital, Manado
  • Max Mantik Department of Child Health, Sam Ratulangi UniversityMedical School/Prof. DR. R. D. Kandoll Hospital, Manado
Keywords: ulcerated hemangioma, propanolol, tumor

Abstract

Hemangiomas are the most frequent vascular
tumors observed in early childhood. The
presentation is unique, with an initial
phase of proliferation, followed by a
phase of slow, spontaneous regression after the age of
1 year.1,2 Most hemangiomas are uncomplicated and
do not require intervention. However, therapy may be
needed if the hemangioma is located at certain body
sites, such as the face, or if it results in a functional
handicap, such as limitation of eye opening. In
addition, ulcerated, rapidly growing hemangiomas
may require treatment.3

References

1. Drolet BA, Esterly NB, Frieden 1]. Hemangiomas in children.
N Engl) Med. 1999;341. 173-81.
2. Naouri M, Lorette G. Angiomas. Rev Prat. 2006;56:1835􀁓
39.
3. Frieden 1], Haggstrom AN, Drolet BA, Mancini AJ,
Friedlander SF, Boon L, et al. Infantile hemangiomas: current
knowledge, future directions. Proceedings of a research
workshop on infantile hemangiomas, April 7􀁓9, 2005,
Bethesda, Maryland, USA. Pediatr Dennatol. 2005;22.383-
406.
4. Chamlin SL, Haggstrom AN, Drolet BA, Baselga E, Frieden
1], Garzon MC, et al. Multicenter prospective study of
ulcerated hemangiomas. J Pediatr. 2007; 151:684􀁓9.
5. Kim HJ, Colombo M, Frieden 1]. Ulcerated hemangiomas:
clinical characteristics and response to therapy. J Am Acad
Dennatol. 2001;44.962-72.
6. Leaute􀁓Labreze C, Dumas de la Roque E, Hubiche T, ooralevi
F, T h ambo JB, Taieb A. Propranolol for severe hemangiomas
of infancy. N Engl) Med. 2008;358.2649-51.
7. Zimmermann Ap, Wie gand S, Werner JA, Eivazi B.
Propranolol therapy for infantile hemangiomas: review of the
literature. Int J Pediatr Otorhinolaryngol. 2010;74:338􀁓42.
8. Oxford Centre of evidence􀁓based medicine. Oxford Centre
for evidence􀁓based medicine levels of evidence [cited
March 2009]; Available from: http://www.cebm.net/index.
aspx?o= 1025
9. Peridis S, Pilgrim G, Athanasopoulos I, Parpounas K. A meta􀁓
analysis on the effectiveness of propranolol for the treatment
of infantile hemangiomas. Int J Pediatr Otorhinolaryngol.
2011;75;455-60.
10. Naouri M, Schill T, Maruani A, Bross F, Lorette G, Rossler
J. Successful treatment of ulcerated hemangioma with propranolol. J Eur Acad Dermatol Venereol. 201O;24:1109􀁜
12.
11. de Graaf MD, Brem jM, Raphael MF, Vos M, Breugem CC,
Pasmans so. Adverse effects of propranolol when used in
the treatment of hemangiomas: a case series of 28 infants. J
Am Acad Dermatol. 2011;65,320-7.
12. Jephson CO, Manunza F, Syed S, Mills NA, Harper J, Hartley
BE. Successful treatment of isolated subglottic hemangioma
with propranolol alone. Int J Pediatr Otorhinolaryngol.
2009;73; 1821-3.
13. Breur JM, de Oraaf M, Breugem CC, Pasmans so.
Hypoglycemia as result of propranolol during treatment
of infantile hemangioma: a case report. Pediatr Dermatol.
2011 ;28, 169-71.
14. Sans V, de la Roque ED, Berge J, Grenier N, Boralevi F,
Mazereeuw􀁜Hautier J, et al. Propranolol for severe infantile
hemangiomas: follow􀁜up report. Pediatrics. 2009;124:e423􀁜
31.
15. Chik KK, Luk CK, Chan HB, Tan HY. Use of propranolol in
infantile hemangioma among Chinese children. Hong Kong
Med j. 2010;16,341-6.
16. Maguiness SM, Frieden 1]. Current management of infantile hemangiomas. Semin Cutan Med Surg. 201O;29:106􀁜14.
17. Storch CH, Hoeger PH. Propranolol for infantile
hemangiomas: insights into the molecular mechanisms of
action. Br j Dermatol. 2010;163,269-74.
18. Buckmiller LM, Munson PD, Dyamenahalli U, Dai Y, Richter
OT. Propranolol for infantile hemangiomas: early experience
at a tertiary vascular anomalies center. Laryngoscope
2010;120,676-81.
19. Schwartz RA, Sidor MI, Musumeci ML, lin RL, MicaH o.
Infantile hemangiomas: a challenge in paediatric dermatology.
J Eur Acad Dermatol Venereol. 201O;24:631􀁜8.
20. Holmes WJ, Mishra A, Oorst C, Liew SH. Propranolol
as firs dine treatment for rapidly proliferating infantile
hAemangiomas.J Plast Reconstr Aesthet Surg. 2011;64:445􀁜
51.
21. Akhavan A, Zippin JH. Current treatments for infantile
hemangiomas. J Drugs Dermatol. 2010;9:176􀁜80.
22. Love IN, Sikka N. Are 1􀁜2 tablets dangerous? Beta􀁜blocker
exposure in toddlers. J Emerg Med. 2004;26:309-14.
23. Lawley LP, Siegfried E, Todd JL. Propranolol treatment for
hemangioma of infancy: risks and recommendations. Pediatr
Dermatol. 2009;26,610-4.
Published
2012-08-31
How to Cite
1.
Gunawan S, Yuri Y, Mantik M. Treatment of ulcerated hemangiomas with propranolol: an evidence-based case report. PI [Internet]. 31Aug.2012 [cited 24Nov.2024];52(4):243-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/405
Section
Case Report
Received 2016-08-31
Accepted 2016-08-31
Published 2012-08-31