Outcomes of prevention of HIV mother-to-child transmission in Cipto Mangunkusumo Hospital

  • Dina Muktiarti Department of Child Health, University of Indonesia Medical School/Dr. Cipto Ma ngunkusumo Hospital, Jakarta
  • Nia Kurniati Department of Child Health, University of Indonesia Medical School/Dr. Cipto Ma ngunkusumo Hospital, Jakarta
  • Arwin Akib Department of Child Health, University of Indonesia Medical School/Dr. Cipto Ma ngunkusumo Hospital, Jakarta
  • Zakiudin Munasir Department of Child Health, University of Indonesia Medical School/Dr. Cipto Ma ngunkusumo Hospital, Jakarta
DOI: https://doi.org/10.14238/pi52.5.2012.294-9
Keywords: mv mother-to-child transmission, HIV, prevention

Abstract

Background Human immunodeficiency virus (HIV) infection
is increasing worldwide. One foute of HIV transmission is from
mother to child, during pregnancy, delivery or breastfeeding.
Prevention of motherô€‚toô€‚child transmission may be an effective
strategy to reduce the cases of new HIV infections.
Objectives To investigate the incidence of HIV infection in
infants born to mothers with HIV and who received prophylactic
therapy at birth, as well as to note the outcomes of HIVinfected
children in this program.
Methods This retrospective study was carried out over a 9ô€‚year
period, from January 20 03 to December 2011. The participants
were HIVexposed infants who attended the HIV clinic, at the
Department of Child Health, Cipto Mangunkusumo Hospital,
Jakarta. Infants were treated according to the prevention of
motherô€‚toô€‚child transmission (PMTCT) protocol at CMH.
Parents' and infants' data was recorded. The end point of this
study was recording of HIVinfection status in the infants.
Results There were 238 infants included in this study. HIV
infection was confirmed in 6 (2.5%) infants, while 170 (71.4%)
subjects were uninfected, and 62 (26.1%) subjects were lost
to followô€‚up. No subjects who underwent complete PMTCT
management were infected. Most subjects were male, fullô€‚tenn,
and delivered by caesarean section in our hospital. The most
frequently observed parental risk factor was intravenous drug
use. Maternal antiretroviral therapy (ART) was given during
pregnancy in most cases. Morbidities in all subjects were low.
Conclusion The PMTCT program at CMH was effective for
reducing the number ofHIVinfected infants from mothers with
HIY. [Paediatrlndanes. 2012;52:294-9].

 

References

1. World Health Organization. Antiretroviral drugs for treating
pregnant women and preventing HIV infection in infants:
towards universal access. Recommendations for a public
health approach. Switzerland: WHO; 2006, p.5-7
2. De Cock KM, Fowler MG, Mercier E, de Vincenzi I, Saba J,
HoffE, et al. P revention of mother􀁥to􀁥child HIV transmission
in resource􀁥poor countries: translating research into policy
and practice. )AMA. 2000;283,1175-82.
3. Joint United Nations P rogramme on HN/AIDS (UNAIDS). UNAIDS data tables 2011. Switmland, UNAIDS; 2011,
p.6-9.
4. Paintsil E, Andiman WA. Update on successes and challenges
regarding mother-to-child transmission of HIY. CUff Opin
Pediatr. 2009;21,94-101.
5. Departemen Kesehatan Republik Indonesia Direktorat
J enderal Pengendalian Penyakit dan Penyehatan Lingkungan.
Laporan situasi perkembangan HIV / AIDS di Indonesia
sampai dengan Maret 2012. (cited 2012 May 11); Available
from: http://www.aidsindonesia.or.id;1aporan-kementerian-
kesehatan-triwulan-kesatu-tahun-2012.html.
6. Kurniati N, Nilamsari T, Akib AAP. Incidence ofHN􀁥infected
infants born to HIV infected mothers with prophylactic
therapy: preliminary report of hospital birth cohort study.
Paediatr Indones. 2006;46,209-13.
7. Sastroasmoro S, editor. Panduan Pelayanan Medis
Departemen Kesehatan Anak RSCM. Jakarta: Departemen
Hmu Kesehatan Anak RS Cipto Mangunkusumo, 2007: p.
26-29.
8. ReadJS, Newell MK. Efficacy and safety of caesarean delivery
for prevention of mother􀁥to􀁥child transmission of HIVl.
Cochrane Database Syst Rev. 2005; 4,CD005479.
9. Lallemant M, Jourdain G, Le Coeur S, Kim S, Koetsawang
S, Comeau AM, et al. A trial of shortened zidovudine
regimens to prevent mother-to-child transmission of human
immunodeficiency virus type 1. Perinatal HIV P revention
Trial (T hailand) Investigators. N Engl) Med. 2000;343,982-
91.
10. Lussiana C, Clemente SVL, GhelardiA, Lonardi M, Tarquino
lAp, Floridia M. Effectiveness of a prevention of mother-to-
child HIV transmission programme in an urban hospital in
Angola. PLoS One. 2012;h36381.
11. SturtAS, Dokubo EK, SintTT. Antiretroviral therapy (ART)
for treating HIV infection in ART􀁥eligible pregnant women.
Cochrane Database Syst Reviews. 2010;3: CD008440.
12. World Health Organization. Antiretroviral drugs for treating
pregnant women and preventing HIV infection in infants:
towards universal access. Recommendations for a public
health approach. 2010 version. Austria: WHO, 2010; p.1􀁥
10
13. McSherry GD, Shapiro DE, Coombs RW, McGrath N, Frenkel
LM, Britto P, et al. The effect of zidovudine in the subset of
infants infacted Mth human immunodeficiendy virus type-1
(Pediatric AIDS clinical trials group protocol 076). J Pediatr.
1999; 134, 717-24.
14. Lallemant M, Jourdain G, Le Coeur SL, Mary JY, Ngo􀁥
Giang􀁥Huong N, Koetsawang S, et al. Single􀁥dose perinatal
nevirapine plus standard zidovudine to prevent mother-to-child transmission of HIV 1 in Thailand. N Engl J Med.
2004;35UI7-28.
15. World Health Organization. HIV and infant feeding. Revised
principles and recommendations. Rapid Advice November
2009. Switmland. WHO, 2009; p.5.
16. Thior I, Lockman S, Smeaton LM, Shapiro RL, Wester C,
Heymann SJ, et al. Breastfeeding plus infant zidovudine
prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce motherô€€³toô€€³child HIV
transmission in Botswana: a randomized trial: the Mashi
Study. JAMA. 2006;296.794-805.
17. Arrive E, Newell ML, Ekouevi DK, Chaix ML, Thiebaut R,
Masquelier B, et al. Prevalence of resistance to nevirapine
in mothers and children after singleô€€³dose exposure to
prevent vertical transmission of HIV 1: a metaô€€³analysis. Int
J Epidemio!. 2007;36.1009-21.
Published
2012-10-31
How to Cite
1.
Muktiarti D, Kurniati N, Akib A, Munasir Z. Outcomes of prevention of HIV mother-to-child transmission in Cipto Mangunkusumo Hospital. PI [Internet]. 31Oct.2012 [cited 25Apr.2024];52(5):294-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/477
Issue
Vol 52 No 5 (2012): September 2012
Section
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Received 2016-09-07
Accepted 2016-09-07
Published 2012-10-31