Outcomes of prevention of HIV mother-to-child transmission in Cipto Mangunkusumo Hospital
Abstract
Background Human immunodeficiency virus (HIV) infection
is increasing worldwide. One foute of HIV transmission is from
mother to child, during pregnancy, delivery or breastfeeding.
Prevention of motherô€‚toô€‚child transmission may be an effective
strategy to reduce the cases of new HIV infections.
Objectives To investigate the incidence of HIV infection in
infants born to mothers with HIV and who received prophylactic
therapy at birth, as well as to note the outcomes of HIVinfected
children in this program.
Methods This retrospective study was carried out over a 9ô€‚year
period, from January 20 03 to December 2011. The participants
were HIVexposed infants who attended the HIV clinic, at the
Department of Child Health, Cipto Mangunkusumo Hospital,
Jakarta. Infants were treated according to the prevention of
motherô€‚toô€‚child transmission (PMTCT) protocol at CMH.
Parents' and infants' data was recorded. The end point of this
study was recording of HIVinfection status in the infants.
Results There were 238 infants included in this study. HIV
infection was confirmed in 6 (2.5%) infants, while 170 (71.4%)
subjects were uninfected, and 62 (26.1%) subjects were lost
to followô€‚up. No subjects who underwent complete PMTCT
management were infected. Most subjects were male, fullô€‚tenn,
and delivered by caesarean section in our hospital. The most
frequently observed parental risk factor was intravenous drug
use. Maternal antiretroviral therapy (ART) was given during
pregnancy in most cases. Morbidities in all subjects were low.
Conclusion The PMTCT program at CMH was effective for
reducing the number ofHIVinfected infants from mothers with
HIY. [Paediatrlndanes. 2012;52:294-9].
Â
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Accepted 2016-09-07
Published 2012-10-31
