Third trimester maternal 1,25-dihydroxyvitamin D and neonatal birth weight

Main Article Content

Yusrawati Yusrawati
Meldafia Idaman
Nur Indrawati Lipoeto



Background The main cause of neonatal mortality is low birth weight. Active form of vitamin D (1,25-dihydroxyvitamin D) increase the efficiency of calcium and phosphorous absorption in intestinal. Deficiency 1,25-dihydroxyvitamin D in pregnant woman was hipothesized relates with low birth weight in neonate.

Objective To determine the relationship between maternal 1,25-dihydroxyvitamin D level and neonatal birth weight.

Methods This was an observational study with cohort design to 47 women in the third trimester pregnancy. This study was cond  ucted on August to December 2014. Subjects were taken from Ibu dan Anak Hospital, Padang, West Sumatera. Maternal blood from antecubital vein was examined for 1,25-dihydroxyvitamin D concentration using enzyme-linked immunosorbent assay (ELISA). Neonatal birth weights were measured right after delivery.  Data were analyzed by Pearson’s correlation and linear regression tests.

Results A positive correlation was found between maternal 1,25-dihydroxyvitamin D level and neonatal birth weight (R=0.910; R2=0.821; P=0.000). The 1,25-dihydroxyvitamin D level had an 82.1% contribution to the baby’s birth weight, while other factors not assessed in this study had less of an effect.

Conclusion There was positive correlation between maternal 1,25-dihydroxyvitamin D levels in the third trimester of pregnancy and neonatal birth weight

Article Details

How to Cite
Yusrawati Y, Idaman M, Lipoeto N. Third trimester maternal 1,25-dihydroxyvitamin D and neonatal birth weight. PI [Internet]. 28Apr.2017 [cited 19Jan.2021];57(2):67-. Available from:
Received 2017-01-28
Accepted 2017-04-07
Published 2017-04-28


1. Fanaroff AA, Stoll BJ, Wright LL, Carlo WA, Ehrenkranz RA, Stark AR, et al. Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol. 2007;196:147.
2. Thorne-Lyman A, Fawzi WW. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatr Perinat Epidemiol. 2012;26:75-90.
3. Flood-Nichols SK, Tinnemore D, Huang RR, Napolitano PG, Ippolito DL. Vitamin D deficiency in early pregnancy. PLoS One. 2015;10:1-15.
4. Engelman CD, Fingerlin TE, Langefeld CD, Hicks PJ, Rich SS, Wagenknecht LE, et al. Genetic and enviromental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab. 2008;93:3381-8.
5. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-81.
6. Hossein-Nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc. 2013;88:720-55.
7. Kratz A, Ferraro M, Sluss PM, Lewandrowski KB. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Laboratory reference values. N Engl J Med. 2004;351;1548-63.
8. Bouillon R, Van Assche FA, Van Baelen H, Heyns W, De Moor P. Influence of the vitamin D-binding protein on the serum concentration of 1,25-dihydroxyvitamin D3. Significance of the free 1,25-dihydroxyvitamin D3 concentration. J Clin Invest. 1981;67:589-96.
9. Kumar R, Cohen WR, Silva P, Epstein FH. Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation. J Clin Invest. 1979;63:342-4.
10. Steichen JJ, Tsang RC, Greer FR, Ho M, Hug G. Elevated serum 1,25-dihydroxyvitamin D concentrations in rickets of very low-birth-weights infants. J Pediatr. 1981;99:293-8.
11. Lips P. Vitamin D deficiency and supplementation in pregnancy. Endocrine Abstracts. 2011;26:21.
12. Wagner CL, Taylor SN, Dawodu A, Johnson DD, Hollis BW. Vitamin D and its role during pregnancy in attaining optimal health of mother and fetus. Nutrients. 2012;4:208-30.