Third trimester maternal 1,25-dihydroxyvitamin D and neonatal birth weight

  • Yusrawati Yusrawati Department of Obstetrics and Gynecology, Andalas University Medical School
  • Meldafia Idaman Medical Student, Andalas University Medical School, Padang, West Sumatera
  • Nur Indrawati Lipoeto Department of Nutrition, Andalas University Medical School, Padang, West Sumatera
Keywords: 1, 25-dihydroxyvitamin D, low birth weight, materna, neonatal

Abstract

Abstract

Background The main cause of neonatal mortality is low birth weight. Active form of vitamin D (1,25-dihydroxyvitamin D) increase the efficiency of calcium and phosphorous absorption in intestinal. Deficiency 1,25-dihydroxyvitamin D in pregnant woman was hipothesized relates with low birth weight in neonate.

Objective To determine the relationship between maternal 1,25-dihydroxyvitamin D level and neonatal birth weight.

Methods This was an observational study with cohort design to 47 women in the third trimester pregnancy. This study was cond  ucted on August to December 2014. Subjects were taken from Ibu dan Anak Hospital, Padang, West Sumatera. Maternal blood from antecubital vein was examined for 1,25-dihydroxyvitamin D concentration using enzyme-linked immunosorbent assay (ELISA). Neonatal birth weights were measured right after delivery.  Data were analyzed by Pearson’s correlation and linear regression tests.

Results A positive correlation was found between maternal 1,25-dihydroxyvitamin D level and neonatal birth weight (R=0.910; R2=0.821; P=0.000). The 1,25-dihydroxyvitamin D level had an 82.1% contribution to the baby’s birth weight, while other factors not assessed in this study had less of an effect.

Conclusion There was positive correlation between maternal 1,25-dihydroxyvitamin D levels in the third trimester of pregnancy and neonatal birth weight

References

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Published
2017-04-28
How to Cite
1.
Yusrawati Y, Idaman M, Lipoeto N. Third trimester maternal 1,25-dihydroxyvitamin D and neonatal birth weight. PI [Internet]. 28Apr.2017 [cited 29Mar.2024];57(2):67-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1207
Section
Articles
Received 2017-01-28
Accepted 2017-04-07
Published 2017-04-28