The effect of vitamin A supplementation on morbidity due to Plasmodium falciparum
Keywords:
vitamin A supplementation, morbidity, Plasmodium falciparum
Abstract
Objective To investigate the effect of vitamin A supplementationon malaria morbidity.
Methods The study was a randomized double-blind placebo-con-
trolled trial, conducted in Panyabungan, Mandailing Natal, North
Sumatera from April 2001 to April 2002. Children aged 6-60 months
suffering from falciparum malaria were randomly assigned to high
dose vitamin A or placebo every 4 months for a year. All children
were treated in accordance with health center policy. Malaria mor-
bidity was assessed from health center visit due to fever, diarrhea,
cough, or abdominal pain. Parents gave reports if their child re-
ceived malaria treatment from other health centers.
Results The number of febrile episodes (probable malaria illness)
was lower in the treatment group than that of control, but not sig-
nificant. The parasitemia was not different between both groups.
There was a significant difference in spleen enlargement between
the treatment group and control (p=0.04). There was no difference
in health center visit between the two groups.
Conclusion The findings suggest that vitamin A supplementation
has only effect on spleen enlargement in malaria.
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H, Hadinegoro SRS, editors. Buku ajar infeksi dan
penyakit tropis. 1 st ed. Jakarta: Balai Penerbit FKUI;
2002. p. 442-71.
2. Susanto L, Pribadi W, Astuti H. Diagnostic of malaria
by the rapid manual test. Med J Indones 1995;4:24-9.
3. Parwati SB. Vitamin A, perkembangan penggunaannya
dalam terapi/ pencegahan. Medika 2000;2:95-103
4. Shankar AH, Genton B, Semba RD, Baisor M, Paino J,
Tamja S, et al. Effect of vitamin A supplementation on
morbidity due to Plasmodium falciparum in young chil-
dren in Papua New Guinea: a randomized trial. Lan-
cet 1999;354:203-9.
5. Nalubola R, Nestel P. The effect of vitamin A nutri-
ture on health: a review. Washington DC: International
Life Sciences Institute Press; 1999. p. 1-83.
6. Binka FN, Ross DA, Morris SS, Kirkwood BR,
Arthur P, Dollimore N, et al. Vitamin A supplemen-
tation and childhood malaria in northern Ghana.
Am J Clin Nutr 1995;61: 853-9.
7. Shankar AH. Nutritional modulation of malaria mor-
bidity and mortality. J Infect Dis 2000;182
(Suppl):37-53.
8. Filteau SM, Morris SS, Abbott RA, Tomkins AM,
Kirkwood BR, Arthur P, et al. Influence of morbidity
on serum retinol of children in a community-based
study in northern Ghana. Am J Clin Nutr
1993;58:192-7.
9. Stoltzfus RJ, Jalal F, Harvey PWJ, Neishem MC. Inter-
actions between vitamin A deficiency and Plasmodium
berghei infection in the rat. J Nutr 1989;119:2030-7.
10. Barreto ML, Santos LMP, Assis AMO, Araujo MPN,
Farenzena GG, Santos PAB, et al. Effect of vitamin A
supplementation on diarrhea and acute lower respiratory
tract infections in young children in Brazil. Lancet
1994;344:228-31.
11. Glasziou PP, Mackerras DEM. Vitamin A supple-
mentation in infectious diseases: a meta-analysis.
BMJ 1993;306:366-70.
Published
2016-10-10
How to Cite
1.
Adillida A, Yusroh Y, Lubis M, Lubis B, Sembiring T, Pasaribu S. The effect of vitamin A supplementation on morbidity due to Plasmodium falciparum. PI [Internet]. 10Oct.2016 [cited 13Nov.2024];44(4):133-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/751
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Received 2016-09-30
Accepted 2016-09-30
Published 2016-10-10
Accepted 2016-09-30
Published 2016-10-10
