Neonatal seizures: clinical manifestations and etiology

Main Article Content

Daisy Widiastuti
Irawan Mangunatmadja
Taralan Tambunan
Rulina Suradi


Background Neonatal seizures or fits are signs of central ner-
vous system (CNS) diseases, metabolic disorders, or other dis-
eases disrupting the CNS. Neonatal seizures are poorly classi-
fied, under-recognized and often difficult to treat. It is important to
recognize the type of neonatal seizures that might be the only sign
of a CNS disorder.
Objective To recognize the type and etiology of neonatal sei-
zures in several hospitals in Jakarta.
Methods This was an observational case series study on full-term
and preterm infants who had seizures during hospitalization in Cipto
Mangunkusumo, Harapan Kita, and Fatmawati Hospitals between
January-June 2005. Neonatal seizures were defined as seizures
occurring in the first 28 days of life of a term infant or 44 completed
weeks of the infant’s conception age of preterm infant.
Results There were 40 neonates who born within the study period
and had seizures. Girls were outnumbered boys. Most neonates
were full-term with birth weight of more than 2500 grams. Analy-
ses were done on 38 neonates with epileptic and non-epileptic
seizures, while the other two who had mixed clinical manifestation
were not included. Most seizures occurred in the first 3 days of life
(23/38). The most common type was focal clonic (12/14) followed
by general tonic (11/24) and motor automatism or subtle (10/24).
The most common etiology was hypoxic ischemic encephalopa-
thy (HIE) (19/38) followed by metabolic disturbances, mainly hy-
pocalcaemia (11/38).
Conclusion Common types of seizures in neonates were focal
clonic, general tonic, and motor automatism (subtle). The most
common etiology was HIE followed by metabolic disturbances,
mainly hypocalcaemia

Article Details

How to Cite
Widiastuti D, Mangunatmadja I, Tambunan T, Suradi R. Neonatal seizures: clinical manifestations and etiology. PI [Internet]. 18Oct.2016 [cited 15Dec.2019];46(6):266-0. Available from:
Author Biographies

Daisy Widiastuti

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

Irawan Mangunatmadja

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

Taralan Tambunan

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

Rulina Suradi

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.
Received 2016-10-17
Accepted 2016-10-17
Published 2016-10-18


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