Association between cord blood IgE levels in newborns and family history of atopic diseases

Main Article Content

Andhika T. Hutapea
Budi Setiabudiawan
Myrna Soepriadi
Diet Sadiah Rustama

Abstract

Background Cord blood-IgE (CB-IgE) levels have been used
widely as a specific marker of atopic diseases. In some previous
studies, CB-IgE levels in subjects with and without a family history
of atopic diseases have been controversial.
Objective To determine the CB-IgE level in newborns and to iden-
tify the association between CB-IgE and family history of atopic
diseases.
Methods A cross-sectional study was done to compare the CB-IgE
levels in neonates with or without a family history of atopic diseases
in mother, father, or siblings. Subjects of this study were 124 new-
borns who consecutively born in Puskesmas Kiaracondong,
Bandung, during the period of March 2001 to July 2002. Subjects
were divided into 2 groups based on history of atopic diseases.
Measurements of CB-IgE levels were done by sandwich ELISA
methods. Data were analyzed by c 2 statistics, t test, ANOVA, and
Dunkan’s test.
Results The mean CB-IgE levels in the group with and without a
family history of atopic diseases were 3.2±2.5 IU/ml and 0.5±0.5
IU/ml (P<0.001), respectively. The mean CB-IgE levels in male
and female infants with a family history of atopic diseases were
3.3±2.7 IU/ml and 3.03±2.2 IU/ml (P>0.05), respectively. Based
on the cut-off point (1.3 IU/ml), CB-IgE levels had significant posi-
tive association with a family history of atopic diseases (OR 156,
95%CI 29.61;1104.24). CB-IgE levels in neonates with 1, 2, and 3
atopic family members were 1.67±0.78 IU/ml, 3.76±2.11 IU/ml, and
6.6±2.7 IU/ml, respectively (F=32.603; P<0.001).
Conclusion Most newborns with a family history of atopic dis-
eases showed high levels of CB-IgE, but there were no correlation
with gender. The probability of having atopic diseases increase in
concord with the number of family with atopic diseases

Article Details

How to Cite
1.
Hutapea A, Setiabudiawan B, Soepriadi M, Rustama D. Association between cord blood IgE levels in newborns and family history of atopic diseases. PI [Internet]. 18Oct.2016 [cited 20Jan.2020];46(5):199-03. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/929
Section
Articles
Author Biographies

Andhika T. Hutapea

Department of Child Health, Medical School, Padjadjaran
University, Hasan Sadikin Hospital, Bandung, Indonesia.

Budi Setiabudiawan

Department of Child Health, Medical School, Padjadjaran
University, Hasan Sadikin Hospital, Bandung, Indonesia.

Myrna Soepriadi

Department of Child Health, Medical School, Padjadjaran
University, Hasan Sadikin Hospital, Bandung, Indonesia.

Diet Sadiah Rustama

Department of Child Health, Medical School, Padjadjaran
University, Hasan Sadikin Hospital, Bandung, Indonesia.
Received 2016-10-16
Accepted 2016-10-16
Published 2016-10-18

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