Lansoprazole for recurrent abdominal pain in adolescents

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Ade Saifan Surya
Selvi Nafianti
Melda Deliana
Supriatmo Supriatmo
Atan Baas Sinuhaji


Background Recurrent abdominal pain is common among adolescents. School absenteeism and lower quality of life are associated with severity of symptoms. Lansoprazole has been used to treat recurrent abdominal pain.

Objective To investigate the effectiveness of lansoprazole as a treatment for recurrent abdominal pain in adolescents.

Methods We conducted a randomized, double-blind, controlled trial from August 2009 to October 2009. Adolescents suffering recurrent abdominal pain were eligible for the study. Simple randomization was done to divide subjects into two groups. Groups received 30 mg of lansoprazole or placebo, once a day for 14 days. Before treatment, we performed laboratory and physical examinations. Pain frequency was measured in number of abdominal pain episodes per month. Duration was measured in minutes and pain intensity was measured by a pain rating scale. Drug efficacy was measured before, during and after intervention. Data was analyzed using Mann-Whitney U-test and t-test.

Results One hundred sixteen recurrent abdominal pain patients were randomized into two groups of 58 patients. There were no statistically significant differences in pain frequency before and after treatment for either the lansoprazole group or the placebo group (P=0.083, 95%CI, -0.033 to 0.021 and P=0.096, 95%CI -0.376 to 0.031, respectively). In addition, there were no significant differences in frequency, duration, and degree of abdominal pain at baseline and after 1, 2 and 3 months of treatment between the two groups.

Conclusion Lansoprazole was not more effective than the placebo for treatment of recurrent abdominal pain among adolescents.

Article Details

How to Cite
Surya A, Nafianti S, Deliana M, Supriatmo S, Sinuhaji A. Lansoprazole for recurrent abdominal pain in adolescents. PI [Internet]. 30Aug.2011 [cited 22Nov.2019];51(4):234-0. Available from:
Received 2016-10-12
Accepted 2016-10-12
Published 2011-08-30


1. Apley J, Naish N. Recurrent abdominal pain: a field survey of 1,000 school children. Arch Dis Child. 1958;33:165-70.
2. Waydert JA, Ball TM, Davis MF. Systemic review of treatment for recurrent abdominal pain. Pediatrics. 2003;111:e1-11.
3. Thiessen PN. Recurrent abdominal pain. Pediatric in Rev. 2002;23:39-48.
4. Zeiter DK, Hyams JS. Clinical aspect of recurrent abdominal pain. Pediatric Ann. 2001;30:17-21.
5. Boey CC, Yap S, Goh KL. The prevalence of recurrent abdominal pain in 11-to 16-year-old Malaysian school children. J Paediatr Child Health. 2000;36:114-6.
6. Plunkett A, Beattie RM. Recurrent abdominal pain in chilhood. J R Soc Med. 2005;98:101-6.
7. Devanarayana NM, Rajindrajith S, Silva HJ. Recurrent abdominal pain in children. Indian Pediatrics. 2009;46:389-97.
8. Saps M, Seshadri R, Sztainberg M, Schaeffer M, Marshall BM, Lorenzo CD. A prospective school-based study of abdominal pain and other common somatic complaint. J Pediatr. 2009;154:322-6.
9. Ramchandani P, Fazel M, Stein A. The impact of recurrent abdominal pain : predictors of outcome in large population cohort. Acta Paediatr. 2007;96:697-701.
10. Dufton LM, Konik B, Colletti R, Stanger C, Boyer M, Morrow S, et al. Effect of stress on pain threshold and tolerance in children with recurrent abdominal pain. Pain. 2008;136:38-43.
11. See MC, Birnbaum AH, Schechter CB, Goldenberg MM, Benkov KJ. Double-blind, placebo-controlled trial of famotidine in children with abdominal pain and dyspepsia. Digestive Disease and Sciences. 2001;46:985-92.
12. Monkemuller K, Malfertheiner P. Drug treatment of functional dyspepsia. World J Gastroenterol. 2006;12:2694-700.
13. Richter JE, Campbell DR, Kahrilas PJ, Huang B, Fludas CL. Lansoprazole compared with ranitidine for the treatment of nonerosive gastroesophageal reflux disease. Arch Intern Med. 2000;160:1803-9.
14. Chitkara DK, Rawat DJ, Talley NJ. The epidemiology of childhood recurrent abdominal pain in western countries: a systematic review. Am J Gastroenterol. 2005;100:1868-75.
15. B Boey CC, Yap SB. An epidemiological survey of recurrent abdominal pain in a rural Malay school. J Paediatr. 1999;35:303-5.
16. Hyams JS, Burke G, Davis PM, Rzepski B, Anbrulons PA. Abdominal pain and irritable bowel syndrome in adolescents: a community based study. J Pediatr. 1996;129:220-6.
17. Devanaryana NM, de Silva DGH, de Silva HJ. Recurrent abdominal pain syndrome in a cohort of Sri Lanka children and adolescents. J Trop Pediatr. 2008;54:178-83.
18. Huang RC, Plamer LJ, Forbes DA. Prevalence and pattern of childhood abdominal pain in an Australian general practice. J Pediatr Child Health. 2000;36:349-53.
19. Rasul CH, Khan MAD. Recurrent abdominal pain in school children in Bangladesh. J Ceylon Coll Physicians. 2000;33:110-4.
20. Boey CCM, Goh KL. Predictors of health care consultation for recurrent abdominal pain among urban school children in Malaysia. J Gastroenterol Hepatol. 2001;16:154-9.
21. Boey CC, Goh KL. Recurrent abdominal pain and consulting behaviour among children in a rural community in Malaysia. Digest Liver Dis. 2001;33:140-4.
22. Noe JD, Li BUK. Navigating recurrent abdominal pain through clinical clues, red flags, and initial testing. Pediatric Ann. 2009;38:259-67.
23. Wardhaugh A, Cosgrove M. The management of recurrent abdominal pain. Curr Paediatrics. 2001;11:276-80.
24. Vanderhoff BT, Tahboub RM. Proton pump inhibitors: an update. Am Fam Physician. 2002;66:273-80.
25. Zimmermann AE, Katona BG. Lansoprazole: a comphrehensive review. Pharmacother. 1997;17:308-26.
26. Faure C, Michaud L, Shaghaghi EK, Popon M, Laurence M, Maugenot JF, et al. Lansoprazole in children: pharmacokinetics and efficacy in reflux oesophagitis. Aliment Pharmacol Ther. 2001;15:1397-1402.