Association between Plasmodium falciparum parasite index and renal function in children
Keywords:
Plasmodium falciparum, parasitemia, ureum, creatinine, glomerular filtration rate
Abstract
Background Falciparum malaria is an acute systemic diseasethat can cause multi organ disorders including in kidney. The aim
of this study was to figure out the association between P.falciparum
parasite index and renal function in children by measuring ureum,
creatinine, and glomerular filtration rate (GFR).
Methods An analytic prospective study was conducted on all hos-
pitalized falciparum malaria patients in the Department of Child
Health, Manado Central General Hospital from November 2001-
February 2002. Low parasitemia was defined if P.falciparum found
was ≤100/100 fields and high parasitemia if >1/1 field. Data were
analyzed by chi-square and student t–test.
Results Among 34 patients, there were 11 with high parasitemia
and 23 with low parasitemia. There were 19 with increased ureum
and 8 with increased creatinine. There was significant elevation of
ureum in high parasitemia (n=10) compared to that in low para-
sitemia patients (n=9) with p=0.004. The increase of serum creati-
nine was found in 2 high parasitemia and in 6 low parasitemia
patients (p=0.611). Mean GFR was 107.63±30.62 in high and
121.94±44.06 in low parasitemia patients (p=0.341).
Conclusion There was a significant association between
P.falciparum parasite index and serum ureum. But there was no
significant association between parasite index and creatinine or
GFR
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falciparum malaria. The clinical management of acute
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New Delhi; 1990. p. 9–17.
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falciparum. Arch Dis Child 1996;74:293-8.
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dren. J Trop Ped 1989;35:291-4.
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values. In: Hay WW, Groothuis JR, Hayward AR, Levin
MJ, editors. Current pediatric diagnosis and treatment.
13 th ed. Stamford, Connecticut: Appleton & Lange;
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Nefrologi anak, vol. 1. Jakarta : IDAI; 1993. p. 33-50.
8. Purwaningsih S. Diagnosis malaria. In: Harijanto PN,
editor. Malaria, epidemologi, patogenesis, manifestasi
klinis & penanganan. Jakarta: EGC; 2000. p. 185-93.
9. Laihad FJ, Gunawan S. Malaria in Indonesia. In:
Harijanto PN, editor. Malaria, epidemologi,
patogenesis, manifestasi klinis & penanganan. Jakarta
EGC; 2000. p. 17-25.
10. Mehta KS, Halankar AR, Makwana PD, Torane PP,
Satija PS, Shah VB. Severe acute renal failure in ma-
laria. J Postgrad Med 2001;47:24-6.
11. Musyawarah, Albar H, Rauf S. Nefropati malaria pada
anak. J. Med Nus 1997;18:52-7.
12. Barsoum RS. Malarial acute renal failure. J Am Soc
Nephrol 2000;11:2147-54.
13. Mashaal H. Physician’s guide to effective management
of cases of malaria. 1993. p. 13-5.
14. Tambajong EH. Patobiologi malaria. In: Harijanto
PN, editor. Malaria, epidemiologi, patogenesis,
manifestasi klinis & penanganan. Jakarta : EGC;
2000. p. 104-6.
15. Harinasuta T, Dunnag D. The clinical features of ma-
laria. In: Wernsdorfer WH, Mc Gregor SI, editors.
Malaria principles and practice of malariology, vol.
1. Edinburg London Melbourne and New York:
Churchill Livingstone; 1988. p. 721-3.
16. Harijanto PN. Gejala klinik malaria berat. In: Harijanto
PN, editor. Malaria, epidemiologi, patogenesis,
manifestasi klinis & penanganan. Jakarta: EGC; 2000.
p. 166-84.
17. WHO. Severe falciparum malaria. Trans R Soc Trop
Med Hyg 2000;94(suppl 1):15-28.
18. Flecther KA, Gilles HM. The chemical pathology of
malaria. In: Wernsdorfer WH, Mc Gregor SI, editors.
Malaria principles and practice of malariology, vol. 1.
Edinburg London Melbourne and New York: Churchill
Livingstone; 1988. p. 652-7.
19. Kim Y. Michael AF, Tarshih P. Infection and nefritis.
In: Chester M, Edellman Jr, editors. Pediatric kidney
disease. 2 nd ed. Boston Toronto London: Little Brown
and Company; 1992. p. 1569-78.
Published
2016-10-10
How to Cite
1.
Umboh A, Muljanto S, Wibisono J. Association between Plasmodium falciparum parasite index and renal function in children. PI [Internet]. 10Oct.2016 [cited 23Dec.2024];43(3):91-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/668
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Received 2016-09-23
Accepted 2016-09-23
Published 2016-10-10
Accepted 2016-09-23
Published 2016-10-10
