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sents a special case of vitamin K deficiency because the four vita-
min K-coagulation factors (factors II,VII,IX,X) are already at physi-
ologically low levels in the newborn. It responds to vitamin K
Objective The aim of this study was to review the incidence, clini-
cal manifestation, and outcome of HDN.
Methods This was a retrospective cross sectional study on 22
patients hospitalized for HDN in the Department of Child Health,
Cipto Mangunkusumo Hospital from January 1997 until Decem-
ber 2001. Data were obtained from medical records.
Results The commonest age group (17 out of 22) was 1–3 month-
old. Normal delivery was found in 19 patients and only 3 patients
received prophylaxis vitamin K. Almost all of them (20 out of 22)
were exclusively breastfed. Seizure, pallor, decreased conscious-
ness, and bulging of the anterior fontanel were significant clinical
manifestations found in 21, 21, 13, and 9 patients respectively.
Based on brain USG and/or CT scan, intracranial hemorrhage was
found in 19 patients. Six out of 22 patients died and 7 patients
survived with handicap
Conclusion Intracranial hemorrhage due to vitamin K mostly oc-
curred at the age of 1 to 3 month-old. The commonest clinical mani-
festations were seizure, pallor, decreased consciousness, and
bulging of the anterior fontanel. Prevention by giving vitamin K rou-
tinely to all newborn babies is recommended
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