Intracranial hemorrhage in hemorrhagic disease of the newborn

Main Article Content

Irawan Mangunatmadja
Rina W Sundariningrum
Hardiono D Pusponegoro
Endang Windiastuti

Abstract

Background Hemorrhagic disease of the newborn (HDN) repre-
sents a special case of vitamin K deficiency because the four vita-
min K-coagulation factors (factors II,VII,IX,X) are already at physi-
ologically low levels in the newborn. It responds to vitamin K
therapy.
Objective The aim of this study was to review the incidence, clini-
cal manifestation, and outcome of HDN.
Methods This was a retrospective cross sectional study on 22
patients hospitalized for HDN in the Department of Child Health,
Cipto Mangunkusumo Hospital from January 1997 until Decem-
ber 2001. Data were obtained from medical records.
Results The commonest age group (17 out of 22) was 1–3 month-
old. Normal delivery was found in 19 patients and only 3 patients
received prophylaxis vitamin K. Almost all of them (20 out of 22)
were exclusively breastfed. Seizure, pallor, decreased conscious-
ness, and bulging of the anterior fontanel were significant clinical
manifestations found in 21, 21, 13, and 9 patients respectively.
Based on brain USG and/or CT scan, intracranial hemorrhage was
found in 19 patients. Six out of 22 patients died and 7 patients
survived with handicap
Conclusion Intracranial hemorrhage due to vitamin K mostly oc-
curred at the age of 1 to 3 month-old. The commonest clinical mani-
festations were seizure, pallor, decreased consciousness, and
bulging of the anterior fontanel. Prevention by giving vitamin K rou-
tinely to all newborn babies is recommended

Article Details

How to Cite
1.
Mangunatmadja I, Sundariningrum R, Pusponegoro H, Windiastuti E. Intracranial hemorrhage in hemorrhagic disease of the newborn. PI [Internet]. 10Oct.2016 [cited 18Oct.2019];43(3):82-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/666
Section
Articles
Author Biographies

Irawan Mangunatmadja

Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta.

Rina W Sundariningrum

Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta.

Hardiono D Pusponegoro

Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta.

Endang Windiastuti

Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta.
Received 2016-09-23
Accepted 2016-09-23
Published 2016-10-10

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