Risk factors of coronary heart disease in children and young adults with parental history of premature coronary heart disease

  • Murti Andriastuti
  • Sudigdo Sastroasmoro
  • Agus Firmansyah
Keywords: premature coronary heart disease, parental history, risk factors, children, young adults


Background Morbidity and mortality of coronary heart disease
(CHD) are recently increasing. This is related to changes in lifestyle,
such as lack of activity and high consumption of fatty diet. The
main cause of CHD is atherosclerosis. The development of ath-
erosclerosis takes a long time, is asymptomatic, and might begin
in childhood. The important risk factors that have roles in increas-
ing the likelihood of atherosclerosis are family history of premature
CHD, hypertension, hyperlipidemia, obesity, smoking and irregu-
lar activity.
Objective The aim of this study was to find out the prevalence of
CHD risk factors in children and young adults who had parental
history of premature CHD.
Methods This was a descriptive cross sectional study conducted
on offspring of premature CHD patients who were admitted in the
intensive cardiology care unit (ICCU) of Cipto Mangunkusumo
Hospital between January 1999 to December 2001 and of prema-
ture CHD patients who visited the Cardiology Clinic of the Depart-
ment of Internal Medicine, Cipto Mangunkusumo Hospital during
March and April 2002. Subjects were aged 12 to 25 year-old.
Results Among the subjects, 40% had hyperlipidemia, 8% had
hypertension, 11% were obese, 21% were active smokers, 41%
were passive smokers, and 73% had irregular activity. Ninety-seven
percents subjects had more than 1 risk factors.
Conclusions The prevalence of hyperlipidemia, hypertension,
obesity, passive smoker, active smoker and irregular activity in
children and young adults with parental history of premature CHD
in this study were higher than those in the normal population.
Most had more than 1 risk factor, increasing the likelihood of CHD.
A screening test should be performed on children with parental
history of premature CHD so that early preventive measures might
be done to minimize the risk factors

Author Biographies

Murti Andriastuti
Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta.
Sudigdo Sastroasmoro
Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta.
Agus Firmansyah
Department of Child Health, Medical School, University of
Indonesia, Cipto Mangunkusumo Hospital, Jakarta.


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How to Cite
Andriastuti M, Sastroasmoro S, Firmansyah A. Risk factors of coronary heart disease in children and young adults with parental history of premature coronary heart disease. PI [Internet]. 10Oct.2016 [cited 20Jan.2022];43(2):51-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/659
Received 2016-09-22
Accepted 2016-09-22
Published 2016-10-10