Association between neutropenia and death rate of bacterial neonatal sepsis
Keywords:
bacterial neonatal sepsis, neutropenia, death rate
Abstract
Background Neonatal sepsis remains a crucial problem with highmorbidity and mortality. Not less than four million neonates die
every year, 99% of which occur in developing countries with
infection as the main cause (36%) of death. The prognostic
factors of bacterial neonatal sepsis vary. However the death rate
in neonatal sepsis with neutropenia is suspected to be higher than
that in non-neutropenic condition.
Objectives The purpose of this study was to identify whether
neutropenia would increase the death risk of bacterial neonatal
sepsis.
Methods We conducted a retrospective cohort study. Subjects
were neonates at Instalasi Maternal Perinatal (IMP) of Dr. Sardjito
Hospital in Yogyakarta who met the eligibility criteria. During
the five-year period Qanuary 2002- January 2007), out of 1821
cases of suspected neonatal sepsis, 365 (16.7%) were found to
have bacterial cause in the culture of body's fluid (blood, urine,
and cerebrospinal). Out of these 16.7% patients suffering from
neutropenia, 39.6% patients died, whereas 9.1 o/o patients were
survive [RR 4.72, (95% CI: 2.49 to 8.93), P < 0.01].
Conclusion Neonates suffering bacterial sepsis with neutropenia
had death risk 4.7 times higher than those who did not have
neutropenia.
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TL, Cunningham MP, Eyal FG, editors. Neonatology. 5rh ed.
Canada: Prentice Hill International; 2005. p. 20-9.
2. IDAI. Standar pelayanan medis kesehatan anak. Sepsis
neonatorum. 1st ed. Jakarta; IDAI 2004. p. 286-90.
3. RSUP Prof. DR. Sardjito. Standar pelayanan medis. Sepsis
neonatorum. Yogyakarta: IDAI 2003. p. 16-23.
4. Bellig LL. Neonatal Sepsis. eMedicine Journal 2002;3,
number 7.
5. LawnJE, CousenS, Zupan]. For the Lancet neonatal survival
steering team. Neonatal survival 1.4 million neonatal deaths:
when? where? why? Lancet 2005;365:891-900.
6. IDAI. UKK Perinatologi. Analisis situasi rumah sakit
rujukan/pendidikan Oi Indonesia Tahun 2003. Jakarta:
IDAI 2005.
7. Cairo MS, Worcester CC, Rucker RW Randomized trial
of granulocyte transfusions versus intravenous immune
globulin therapy for neonatal neutropenia and sepsis. J Pediatr
1992; 120:281-5.
8. Schibler K, Osborne K, Leung L, Le T, Baker S, Thompson
DA. Randomized placebo-controlled trial of granulocyte
colony-stimulating factor administration to newborn infants
with neutropenia and clonical sign of early-onset sepsis.
Pediatrics 1998; 102:6-13.
9. Weber MAR, Candiani CL, Garcia JLA, Castrellon PG,
Arriga FS. Morbidity and mortality from neonatal sepsis
in a tertiary care-level hospital. Salud Publica Mex
2003;45:90-5.
10. Funke Annete, Berner R, Traichel B, Schmeisser 0, Leititis
JU, Neinemeyer CM. Frecuency, natural course, and outcome
of neonatal neutropenia. Pediatrics 1999; 106:45-51.
11. Christensen RD, Rothstein G, Anstall HG, Bybee B.
Granulocyte transfusion in neonates with bacterial infection,
neutropenia, and depletion of mature marrow neutrophyl.
Pediatrics 1982; 70: 1-6.
12. Permono B, Sutaryo, Urgasena lOG, Windiastuti E,
Abdulsalam M. Sel darah putih. In: Hematologi dan onkologi
anak. Jakarta: IDAI; 2005. p. 101.
Published
2016-09-15
How to Cite
1.
Rochmah E, Haksari E, Mulatsih S. Association between neutropenia and death rate of bacterial neonatal sepsis. PI [Internet]. 15Sep.2016 [cited 20Apr.2024];48(5):284-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/607
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Received 2016-09-12
Accepted 2016-09-12
Published 2016-09-15
Accepted 2016-09-12
Published 2016-09-15
