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morbidity and mortality. Not less than four million neonates die
every year, 99% of which occur in developing countries with
infection as the main cause (36%) of death. The prognostic
factors of bacterial neonatal sepsis vary. However the death rate
in neonatal sepsis with neutropenia is suspected to be higher than
that in non-neutropenic condition.
Objectives The purpose of this study was to identify whether
neutropenia would increase the death risk of bacterial neonatal
Methods We conducted a retrospective cohort study. Subjects
were neonates at Instalasi Maternal Perinatal (IMP) of Dr. Sardjito
Hospital in Yogyakarta who met the eligibility criteria. During
the five-year period Qanuary 2002- January 2007), out of 1821
cases of suspected neonatal sepsis, 365 (16.7%) were found to
have bacterial cause in the culture of body's fluid (blood, urine,
and cerebrospinal). Out of these 16.7% patients suffering from
neutropenia, 39.6% patients died, whereas 9.1 o/o patients were
survive [RR 4.72, (95% CI: 2.49 to 8.93), P < 0.01].
Conclusion Neonates suffering bacterial sepsis with neutropenia
had death risk 4.7 times higher than those who did not have
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