Association between neutropenia and death rate of bacterial neonatal sepsis

Main Article Content

Elly Noer Rochmah
Ekawaty Lutfia Haksari
Sri Mulatsih


Background Neonatal sepsis remains a crucial problem with high
morbidity and mortality. Not less than four million neonates die
every year, 99% of which occur in developing countries with
infection as the main cause (36%) of death. The prognostic
factors of bacterial neonatal sepsis vary. However the death rate
in neonatal sepsis with neutropenia is suspected to be higher than
that in non-neutropenic condition.
Objectives The purpose of this study was to identify whether
neutropenia would increase the death risk of bacterial neonatal
Methods We conducted a retrospective cohort study. Subjects
were neonates at Instalasi Maternal Perinatal (IMP) of Dr. Sardjito
Hospital in Yogyakarta who met the eligibility criteria. During
the five-year period Qanuary 2002- January 2007), out of 1821
cases of suspected neonatal sepsis, 365 (16.7%) were found to
have bacterial cause in the culture of body's fluid (blood, urine,
and cerebrospinal). Out of these 16.7% patients suffering from
neutropenia, 39.6% patients died, whereas 9.1 o/o patients were
survive [RR 4.72, (95% CI: 2.49 to 8.93), P < 0.01].
Conclusion Neonates suffering bacterial sepsis with neutropenia
had death risk 4.7 times higher than those who did not have

Article Details

How to Cite
Rochmah E, Haksari E, Mulatsih S. Association between neutropenia and death rate of bacterial neonatal sepsis. PI [Internet]. 15Sep.2016 [cited 27Sep.2020];48(5):284-. Available from:
Author Biographies

Elly Noer Rochmah

Department of Child Health, Medical School, Gadjah Mada
University, Yogyakarta, Indonesia.

Ekawaty Lutfia Haksari

Department of Child Health, Medical School, Gadjah Mada
University, Yogyakarta, Indonesia.

Sri Mulatsih

Department of Child Health, Medical School, Gadjah Mada
University, Yogyakarta, Indonesia.
Received 2016-09-12
Accepted 2016-09-12
Published 2016-09-15


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