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important role in dengue hemorrhagic fever pathogenesis.
Thrombomodulin is a part of glycoprotein membrane in
endothelial cells. Therefore, thrombomodulin level will
increase if endothelial cells disruption occurs.
Objective To acknowledge the correlation between the
degree of dengue hemorrhagic fever and thrombomodulin
Methods This was a cross-sectional study. Subjects were
hospitalized pediatric patients with age ranging from one
to 13 year old in pediatric ward at Pro£ Dr. R.D. Kandou
Hospital, Manado, who had fever. Three milliliters of blood
were taken from vein, and were divided for two tests which
were routine blood analysis and thrombomodulin analysis.
Different data resulted from the dengue hemorrhagic fever
group were processed, and analyzed statistically using F Test
and LSD (least significant difference) test. The relation
between dengue hemorrhagic fever and thrombomodulin
was analyzed with Spearman correlation coefficient.
Results There was a significant result in the difference of
thrombomodulin level on four dengue hemorrhagic fever
groups which were classified according to the severity of
dengue hemorrhagic fever. There was a very significant
positive correlation between the severity of dengue
hemorrhagic fever and thrombomodulin level in detecting
endothelial cells impairment.
Conclusion Thrombomodulin level can be used as a
marker to detect endothelial cells impairment in dengue
hemorrhagic fever. Higher grade of dengue hemorrhagic
fever will have higher thrombomodulin level.
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