Elimination and provocation test in cow's milk hypersensitive children

  • Mulya Safri
  • Nia Kurniati
  • Zakiudin Munasir
Keywords: hypersensitivity, milk, immuglobulin E, child


Background Allergic disease in infancy mostly related to cow's
milk allergy. The prevalence of cow's milk hypersenstivity in chil-
dren has increased steadily in the past years; therefore diagnostic
accuracy is important and every symptomatic child with positive
specific lgE should be followed by elimination and provocation.
Objective To diagnose cow's milk hypersensitivity on children un-
der three years old using elimination and provocation methods.
Methods This was a clinical diagnosis study, in which children
with allergy symptoms were examined for cow's milk sensitivity
using prick test or lgE Radioallergosorbent test (RAST). Those
with positive results underwent an elimination for minimal of 2
weeks and were challenged aterwards. The study was a qualitative
diagnostic test with the gold standard of recurrence of symptoms
after challenge test.
Results There were forty subjects included in the challenge pro-
cess with mean age of 17 months old. Boys and girls were equally
distributed. There were 6 7% subjects with positive results on
challenge with positive prick test and 64% positive challenge with
history of positive lgE RAST. Sixty-five percents of subjects with
positive results on challenge had more than 2 weeks elimination
period. There was no statistical significance found in children
with positive results on challenge, using neither prick test or
Conclusions Cow's milk protein allergy can be diagnosed on chil-
dren less than 3 years old by applying elimination and challenge
procedure. lgE sensitivity alone can not determine hypersensitivity

Author Biographies

Mulya Safri
Department of Child Health, Dr. Zaenocl Abidin Hospital, Banda
Acch, Indonesia.
Nia Kurniati
Department of Child Health, Dr. Zaenocl Abidin Hospital, Banda
Acch, Indonesia.
Zakiudin Munasir
Department of Child Health, Dr. Zaenocl Abidin Hospital, Banda
Acch, Indonesia.


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How to Cite
Safri M, Kurniati N, Munasir Z. Elimination and provocation test in cow’s milk hypersensitive children. PI [Internet]. 31Aug.2008 [cited 5Mar.2024];48(4):253-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/577
Received 2016-09-10
Accepted 2016-09-10
Published 2008-08-31