Evidence based case report: Pyridoxine supplementation in children with pervasive developmental disorders
Abstract
Pervasive developmental disorders (PDD)
is defined as a neurodevelopmental disorder,
c haract erized by social withdrawal,
communication deficits, and repetitive
behaviors. PDD include autistic disorder, Rett's
syndrome, childhood disintegrative disorder, Asperger' s
syndrome, and pervasive developmental disorder not
otherwise specified or atypical autism.1 Update of
epidemiological studies published between 1966 and
2006 show reports of estimated prevalence for autism
has varied between 3 .31 and 86 children per 10,000, 2
and predominantly occurs in males than females
(male:female ratio = 4: 1) .3
There is a hypothesis that behavioral problems
in children with pervasive developmental disorder
are highly associated with the neurotransmitter
imbalances. Therefore, psychotropic medications (eg.
atypical antipsychotics, selective serotonin reuptake
inhibitors, and psychostimulants), which work on
dopamine and serotonin receptors, are the FDAapproved
medications for PDD.4 On the other hands,
the use of novel, unconventional, and/or off- label
treatments associated with the n eurotransmitters
pathway for children with POD is increasing and
more common.
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Accepted 2016-09-09
Published 2014-06-30
