Total serum IgE levels in soil-transmitted helminth infected children with atopy symptoms

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Hendri Wijaya
Lily Irsa
Supriatmo Supriatmo
Sjabaroeddin Loebis
Rita Evalina


Background High total serum immunoglobulin E (IgE) levels
and eosinophilia are markers for atopy, but other factors may
also play a key role in affecting atopy, such as intestinal parasitic
infection. Helminthiasis has been associated with a reduced risk
of atopy and asthma symptoms in areas with high prevalence of
parasitic infections.
Objective To assess for associations between total serum IgE
level and soil-transmitted helminthiasis (STH) infection, as well
as between STH infection and allergy symptoms.
Methods We conducted a cross-sectional stu dy on 84
consecutively-enrolled children , aged 7- 13 years, in the
Secanggang Subdistrict, Langkat District, North Sumatera
Province. Subjects were enrolled into one of two groups, with or
without STH infection. Total serum IgE measurements and stool
STH examinations were performed in all subjects. Data on atopy
or allergy symptoms were obtained by parental interview.
Results The 42 subjects with STH infection had significantly
higher mean total serum lg E levels than the 42 subjects without
infec tion, 1,13 1.26 IU/mL and 744.76 IU/mL, respectiv ely
(P = 0.029). We also fo und significant positive association s
between STH infection and asthma symptoms (P= 0.049), as well
as eczema symptoms (P=0.044).
Conclusion Mean total serum IgE level is higher in STHinfected
subjects than in those without infection. In addition,
STH infection is positively associated with asthma and eczema

Article Details

How to Cite
Wijaya H, Irsa L, Supriatmo S, Loebis S, Evalina R. Total serum IgE levels in soil-transmitted helminth infected children with atopy symptoms. PI [Internet]. 30Jun.2014 [cited 20Sep.2019];54(3):149-. Available from:
Received 2016-09-09
Accepted 2016-09-09
Published 2014-06-30


1. Kirwan K, Asaolu SO, Molloy SF, Abiona TC, Jackson AL, Holland CV. Patterns of soil-transmitted h elminth infection and impact of four-monthly albendazole treatments in preschool children from semi-urban communities in Nigeria: a double-blind placebo-controlled randomised trial. BMC Infect Dis. 2009;9:20. doi:10.1186/1471-2334-9-20.
2. Brooker S, Clements AC, Bundy DA. Global epidemiology, ecology and control of soil-transmitted helminth infections. Adv Parasitol. 2006;62:221-61.
3. Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, et al. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 2006;367:1521-32.
4. Cooper PJ. Intestinal worms and human allergy. Parasite Immunol. 2004;26:455-67.
5. Hotez PJ, de Silva N, Brooker S, Bethony J. Soil-transmitted helminth infections: the nature, causes and burden of the condition. In: Working Paper No. 3, Disease Control Priorities Project. Bethesda, Maryland: Fogarty International Center, National Institutes of Health; 2003. p. 1-7.
6. Firmansyah I, Ginting SA, Lubis M, Lubis IZ, Pasaribu S, Lubis CP. Factors associated with the transmission of soiltransmitted helminthiasis among schoolchildren. Paediatr Indones. 2004;44:127-32.
7. Tjitra E. Penelitian-penelitian "Soil-Transmitted Helminth." di Indonesia. Cermin Dunia Kedokteran. 1991;72:13-17.
8. Lynch NR, Hagel IA, Palenque ME, Di Prisco MC, Escudero JE, Cerao LA, et al. Relationship between helminthic infection and IgE response in atopic and n onatopic children in a tropical environment. J Allergy Clin Immunol. 1998;101:217-21.
9. Smits HH, Everts B, Hartgers FC, Yazdanbakhsh M. Chronic helminth infections protect against allergic diseases by active regulatory processes. Curr Allergy Asthma Rep. 2010;10:3-12.
10. Dold S, Heinrich J, Wichmann HE, Wjst M. Ascaris-specific IgE and allergic sensitization in a cohort of school children in the former East Germany. J Allergy Clin Immunol. 1998;102:414-20.
11. Katz N, Chaves A, Pellegrino J. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev Inst Med Trop Sao Paulo. 1972; 14:397-400.
12. Montresor A, Crompton DWT, Hall A, Bundy DAP, Savioli L. Guidelines for the evaluation of soil-transmitted helminthiasis and schistosomiasis at community level. A guide for managers of control programmes. Geneva: World Health Organization; 1998. pp. 1-45.
13. Montresor A, Crompt on DWT, Hall A, Bundy DAP, Savioli L. Guidelines for the evaluation of soil-transmitted helminthiasis and schistosomiasis of community level. Geneva: World Health Organization; 1998. p. 3-49.
14. Cooper PJ. Can intestinal helminth infections (geohelmiths) affect the development and expression of asthma and allergic disease? Clin Exp Immunol. 2002;128:398-404.
15. Reina Ortiz M, Schreiber F, Benitez S, Broncano N, Chico ME, Vaca M, et al. Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study. PLoS Negl Trop Dis. 2011;5:el157. doi: 10.1371/journal.pntd.0001157.
16. Palmer LJ, Celedon JC, Weiss ST, Wang B, Fang Z, Xu X. Ascaris lumbricoules infection is associated with increased risk of childhood asthma and atopy in rural China. Am J Respir Crit Care Med. 2002;165:1489-93.
17. Cooper PJ, Ayre G, Martin C, Rizzo JA, Ponte EV, Cruz M. Geohelminth infections: a review of the role ofigE and assessment of potential risks of anti-IgE treatment. Allergy. 2008;63:409-17.
18. Cooper PJ, Chico ME, Rodrigues LC, Ordonez M, Strachan D, Griffin GE, et al. Reduced risk ofatopy among school-age children infected with geohelminth parasites in a rural area of the tropics. J Allergy Clin Immunol. 2003;111:995-1000.
19. Hunninghake GM, Soto-Quiros ME, Avila L, Ly NP, Liang C, Sylvia JS, et al. Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica. J Allergy Clin Immunol. 2007;119:654-61.
20. Huang SL, Tsai PF, Yeh YEN egative association of Enterobius infestation with asthma and rhinitis in primary school children in Taipei. Clin Exp Allergy. 2002;32:1029-32.
21. Pereira MU, Sly PD, Pitrez PM, Jones MH, Escouto D, Dias AC, et al. Nonatopic asthma is associated with helminth infections and bronchiolitis in poor children. Eur Respir J. 2007;29:1154-60.
22. Medeiros D, Silva AR, Rizzo JA, Motta ME, Oliveira FH, Sarinho ES. Total IgE level in respiratory allergy: study of patients at high risk for helminthic infection. J Pediatr (Rio J). 2006;82:255-9.
23. Cooper PJ, Chico ME, Bland M, Griffin GE, Nutman TB. Allergic symptoms, atopy, and geohelminth infections in a rural area of Ecuador. Am J Respir Crit Care Med. 2003;168:313-7.
24. Schafer T, Meyer T, Ring J, Wichmann HE, Heinrich J. Worm infestation and the negative association with eczema (atopic/nonatopic) and allergic sensitization. Allergy. 2005;60:1014-20.
25. Wordemann M, Diaz RJ, Heredia LM, Collado Madurga AM, Ruiz Espinosa A, Prado RC, et al. Association of atopy, asthma, allergic rhinoconjunctivitis, atopic dermatitis and intestinal helminth infections in Cuban children. Trop Med Int Health. 2008;13:180-6.
26. Helmby H. Helminths and our immune system: friend or foe? Parasitol Int. 2009;58:121-7.