Plasma lipid profile and leptin concentration in super-obese children
Keywords:
children, obesity, leptin, lipid profile
Abstract
Background Leptin induced weight loss is completely specificfor adipose tissue loss, whereas food restriction result in both loss
of adipose tissue and lean body mass in mammals. Most obese
person has high endogenous leptin levels, indicating leptin
resistance. There has been lack of data regarding plasma leptin
level in Indonesian obese children.
Objective This study was aimed to investigate the plasma leptin
level and lipid profile in super-obese children.
Methods This was a cross sectional study performed in Pediatric
Out Patient Clinic Mangunkusumo Hospital and Private Women
& Children Hospital in Eastern part of Jakarta. Super-obese is
defined as children with BMI above 97 centiles CDC 2000 chart.
Blood sample was obtained from all subjects, consisted of
peripheral blood picture, lipid profiles and leptin level.
Results Seventy nine super-obese children were eligible with age
ranged between 12 months and 180 months and mean of age was
84.9 months (SD 36.8). More than 60% subjects had high LDL
cholesterol, while 19% had low HDL level. The lowest leptin
blood level was 2.877 μ g/dL, while the highest was 70.430 μ g/dL
(mean 23.990; SD 12.726). Forty five subjects, all boys, had
increased plasma leptin level.
Conclusions In super-obese children, most of the subject
experienced hyperlipidemia (LDL cholesterol) followed by
hypertriglyceridemia. There was small number of low HDL
cholesterol found. Super-obese girls had normal serum leptin level,
in contrast, more than 60% super-obese boys had elevated serum
leptin level.
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Shieh S. Clustering of cardiovascular disease risk factor
among obese school children: the Taipeh Children Heart
Study. Am J Clin Nutr 1998; 67:1141-6.
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J, Karlsson C, et al. Familial predisposition for obesity may
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Nutr 1998; 67:1119-23.
16. Ostlund RE, Yang JW, Klein S, Gingerich R. Relation between
plasma leptin concentration and body fat, gender, diet, age
and metabolic covariates. J Clin Endocrinol Metab 1996;
81:3909-13.
17. Wolthers DO, Heuck C, Skjaerbek C. Diurnal rhythm in
serum leptin. J Pediatr Endocrinol Metab 1999;12:863-6.
18. Hytinantii T, Koistinen HA, Koivisto VA, Karonen SL,
Andersson S. Changes in leptin concentration during the early
postnatal period: adjustment to extrauterine life? Pediatr Res
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Jinagouda SD, et al. Diurnal and ultradian rhytmicity of
plasma leptin: effect of gender and adiposity. J Clin Endocrinol
Metab 1998; 83:453-9.
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Chu F, et al. Effect of gender, body composition, and menopause
on plasma concentration of leptin. J Clin Endocrinol Metab
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21. Mann DR. Johnson AOK, Gimpel T, Castracane VD.
Changes in circulating leptin, leptin receptor and gonadal
hormones from infancy until advanced age. J Clin Endocrinol
Metab 2003; 88:3339-45.
F, Eliakin A, et al. Consensus statement : childhood obesity.
J Clin Endocrine Metab 2005; 90:1871-87.
2. Freemark M. Pharmacotherapy of childhood obesity. Diabetes
Care 2007; 30:395-402.
3. Warden NS, Warden CH. Pediatric obesity. An overview of
etiology and treatment. Pediatr Endocrinol 1997:44:339-61.
4. Bray GA, York DA. Leptin and clinical medicine: a new piece
in the puzzle of obesity. J Clin Endocrinol Metab 1997;
82:2771-6.
5. Mantzoros CS. The role of leptin in human obesity and
disease: a review of current evidence. Ann Intern Med 1999;
130:671-80.
6. Friedman JM. Leptin, leptin receptor and the control of body
weight. Nutr Rev 1998; 56:S38-46.
7. Singhal A, Farooqi IS, Rahilly SO, Cole TJ, Fewtrell M, Lucas
A. Early nutrition and leptin concentration in later life. Am
J Clin Nutr 2002; 75:993-9.
8. Hoppin AG, Kaplan LM. The leptin era: new insight into
the mechanism of body weight homeostasis. J Pediat
Gastroenterol Nutr 1999; 29:250-64.
9. Brunner L, Levens N. The regulatory role of leptin in food
intake. Curr Opin Nutr Metab Care 1998; 1:565-71.
10. Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham
CH, Prentice AM, et al. Effect of recombinant leptin therapy
in a child with congenital leptin deficiency. N Eng J Med
1999; 342:879-84.
11. Yannakoulia M, Yiannakouris N, Bluher S, Matalas A, Klimis-
Zacas D, Mantzoros CS. Body fat mass and macronutrient
intake in relation to circulating soluble leptin receptor, free
leptin index, adiponectin and resistin concentrations in
healthy human. J Clin Endocrinol Metab 2003; 88:1730-6.
12. Singhal A, Farooqi IS, , Cole TJ, O’Rahilly S, Fewtrell M,
Kattenhorn M, et al. Influence of leptin on arterial distensibility.
A novel link between obesity and cardiovascular disease.
Circulation 2002; 106:1919-24.
13. Feng Chu N, Rimm EB, Jiang Wang D, Shin Liou H, Ming
Shieh S. Clustering of cardiovascular disease risk factor
among obese school children: the Taipeh Children Heart
Study. Am J Clin Nutr 1998; 67:1141-6.
14. Bellu R, Ortisi MT, Scaglioni S, Agostoni C, Salanitri
VS, Riva E, et al. Lipid and apoprotein A-1 and B level
in obese school-age children: result of a study in the
Milan area. J Pediatr Gastroenterl Nutr 1993; 16:446-
50.
15. Lindroos AK, Lissner L, Carlsson B, Carlsson LMS, Torgerson
J, Karlsson C, et al. Familial predisposition for obesity may
modify the predictive value of serum leptin concentration
for long term weight change in obese women. Am J Clin
Nutr 1998; 67:1119-23.
16. Ostlund RE, Yang JW, Klein S, Gingerich R. Relation between
plasma leptin concentration and body fat, gender, diet, age
and metabolic covariates. J Clin Endocrinol Metab 1996;
81:3909-13.
17. Wolthers DO, Heuck C, Skjaerbek C. Diurnal rhythm in
serum leptin. J Pediatr Endocrinol Metab 1999;12:863-6.
18. Hytinantii T, Koistinen HA, Koivisto VA, Karonen SL,
Andersson S. Changes in leptin concentration during the early
postnatal period: adjustment to extrauterine life? Pediatr Res
1999; 45:197-201.
19. Saad MF, Riad-Gabriel MG, Khan A, Sharma A, Michael R,
Jinagouda SD, et al. Diurnal and ultradian rhytmicity of
plasma leptin: effect of gender and adiposity. J Clin Endocrinol
Metab 1998; 83:453-9.
20. Rosenbaum M, Nicolson M, Hirst J, Heymfiels SB, Galagher D,
Chu F, et al. Effect of gender, body composition, and menopause
on plasma concentration of leptin. J Clin Endocrinol Metab
1996; 81:3424-7.
21. Mann DR. Johnson AOK, Gimpel T, Castracane VD.
Changes in circulating leptin, leptin receptor and gonadal
hormones from infancy until advanced age. J Clin Endocrinol
Metab 2003; 88:3339-45.
Published
2007-10-31
How to Cite
1.
Hendarto A, Nasar S, Sjarif D. Plasma lipid profile and leptin concentration in super-obese children. PI [Internet]. 31Oct.2007 [cited 29Nov.2024];47(5):221-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/418
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Received 2016-09-01
Accepted 2016-09-01
Published 2007-10-31
Accepted 2016-09-01
Published 2007-10-31
