UCP3 gene polymorphism and insulin resistance in obese female adolescents

  • Dian Eurike Department of Histology and Cell Biology, Gadjah Mada University Medical School, Yogyakarta
  • Harry Freitag Luglio Muhammad Department of Health Nutrition, Gadjah Mada University Medical School, Yogyakarta
  • Rina Susilowati Department of Histology and Cell Biology, Gadjah Mada University Medical School, Yogyakarta
  • Madarina Julia Department of Child Health, Gadjah Mada University Medical School, Yogyakarta
DOI: https://doi.org/10.14238/pi52.3.2012.152-6
Keywords: UCP3, polymorphism, insulin resistance, obesity, female adolescents

Abstract

Background A previous study on obese female adolescents in
Yogyakarta done in the year 2007 suggests that genetic factors
might influence insulin resistance. One genetic factor that has
been associated \\lith insulin resistance in other populations is
the ô€55C;T polymorphism in the uncoupling protein 3 (UCP3)
gene.
Objective To investigate an association between the ô€55C;T
polymorphism in the UCP3 gene and insulin resistance in obese
female adolescents in Yogyakarta.
Methods A total of79 obese female adolescents were enrolled in
this crossô€sectional study. Genotyping of the ô€ 5 SC/T polymorphism
in the UCP3 gene was performed by polymerase chain reactionô€
restriction fragment length polymorphism (PCRô€RFLP).
Results The TiT homozygous individuals had a higher risk of
insulin resistance (OR 2.3; 95% CI 0.4 to 14.1), as well as higher
fasting insulin concentration and homeostatic model assessment
for insulin resistance (HOMAô€IR) compared to individuals v.ith
other genotypes. The T allele carriers also had a higher risk of
insulin resistance (OR 1.3; 95% CI 0.7 to 2.5), as well as higher
fasting insulin concentration and HOMAô€ IR compared to C
allele carriers. However, none of these results were statistically
significant (P > 0.05).
Conclusion The TiT genotype and T allele of the UCP3 gene
ô€55CiT polymorphism was not significantly associated increased
risk of insulin resistance in obese female adolescents in Yogyakarta.
[Paediatr lndanes. 2012;52:152-6].

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Published
2012-06-30
How to Cite
1.
Eurike D, Muhammad H, Susilowati R, Julia M. UCP3 gene polymorphism and insulin resistance in obese female adolescents. PI [Internet]. 30Jun.2012 [cited 25Apr.2024];52(3):152-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/382
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Vol 52 No 3 (2012): May 2012
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Received 2016-08-30
Accepted 2016-08-30
Published 2012-06-30