Leptin, blood pressure, and left ventricular mass in obese adolescents

  • David Kaunang Department of Child Health, Sam Ratulangi University Medical School, Prof. Dr. R. D. Kandou Hospital
  • Handri Widodo Department of Child Health, Sam Ratulangi University Medical School, Prof. Dr. R. D. Kandou Hospital
  • Vivekenanda Pateda Department of Child Health, Sam Ratulangi University Medical School, Prof. Dr. R. D. Kandou Hospital
Keywords: Leptin, blood pressure, left ventricular mass, obesity


Background Obesity is characterized by an excessive accumulation
of body fat and has become a major health problem in industrialized
societies especially with regards to heart disease. Adipose tissue
derived hormone (leptin) can cause obesity. Leptin acts to reduce
food consumption and enhance energy expenditure.
Objective To assess for a relationship between leptin, blood
pressure, and left ventricular mass in obese adolescents.
Methods This was a cross-sectional study conducted from
November 2011 to April 2012 in Prof. Dr. RD. Kandou Hospital.
This study included obese and healthy adolescents aged 13-18
years who attended school in Tuminting District ofManado. Each
subject underwent measurements of body mass index (BMI), boold
pressure, and plasma leptin level. Correlation regression test was
used for data analysis. Results were considered to be statistically
significant if P values < 0.05.
Results There was a significant relationship between leptin and
left ventricular mass (r=-0.467; P=0.006), as well as leptin and
systolic blood pressure (r=-0.366; P=0.028), but not between
leptin and diastolic blood pressure (r=-0.261; P=0.09). We also
found significant relationships between systolic blood pressure and
left ventricular mass (r=0.724; P<0.001), and between diastolic
blood pressure and left ventricular mass ( r=0.615; P< 0.001) in
obese adolescents.
Conclusion Higher leptin levels are associated with lower left
ventricular mass and lower systolic blood pressure, but are not
associated with diastolic blood pressure.


1. Williams CL, Gulli MT, Deckelbaum RJ. Prevention and
treatment of childhood obesity. Curr Atheroscler Rep.
2. Mexitalia M. Nutrisi pencegahan: prudent diet. In:
Gunawan G, editor. Tumbuh kembang; nutrisi dan en dokrin.
Naskah lengkap Pendidikan Kedokteran Berkelanjutan V;
Banjarmasin 18- 19 Februari 2006. Banjarmasin: IDAI cabang
Kalsel; 2006. p. 29-42.
3. Deckelbaum RJ, Williams CL. Childhood obesity: the health
issue. Obes Res. 2001;9:239S-43S.
4. Prentice AM. The emerging epidemic of obesity in developing
countries. IntJ Epidemiol. 2006;35:93-9.
5. Pilcova R, Sulcova J, Hill M, Blaha P, Lisa L. Leptin levels
in obese children: effects of gender, weight reduction and
androgens. Physiol Res. 2003;52:53-60.
6. La Cava A, Matarese G. The weight of leptin in immunity.
Nat Rev Immunol. 2004;4:371-9.
348 • Paediatr Irulones, Vol. 53, No. 6, November 2013
7. Hanevold C, Waller J, Daniels S, Portman R, Sorof J.
The effect of obesity, gender and ethnic group on left
ventricular hypertrophy and geometry in hypertensive
children: a collaborative study of the International Pediatric
Hypertension Association. Pediatrics. 2004; 113 :3 28-33.
8. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP.
Prognostic implications of echocardiographically determined
left ventricular mass in the Framingham Heart Study. N Engl
J Med.1990;322: 1561-6.
9. Bahrun D. Hipertensi Sistemik. In: Alatas H, Tambunan T,
Trihono P, Pardede SO, editors. Buku Ajar Nefrologi Anak.
2nd ed. Jakarta: Balai Penerbit FKUI; 2002. p. 242-87.
10. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo
E, Sachs I, Reichek N. Echocardiographic assessment ofleft
ventricular hypertrophy: comparison with necropsy findings.
AmJ Cardiol. 1986;57:450-458.
11. Myung KP. Noninvasive techniques. In: Pediatric cardiology
for practitioners. 4,h ed. USA: Mosby; 2002. p. 67-9.
12. de Simone G, Daniels SR, Devereux RB, Meyer RA, Roman
MJ, de Divitis 0, et al. Left ventricular mass and body size in
normotensive children and adults: assessment of allometric
relations and impact of overweight. J Am Coll Cardiol.
1992;20: 1251-60.
13. Rajapurohitam V, Gan XT, Kirshenbaum LA, Karmazyn M.
The obesity- associated peptide leptin induces hypertrophy
in neonatal rat ventricular myocites. Circ Res. 2003 ;9 3 :277-
14. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang
Y, et al. Leptin level in human and rodent: measurement of
plasma leptin and ob RNA in obese and weight-reduced
subjects. Nat Med. 1995; 1:1155-61.
15. Paolisso G, Tagliamonte MR, Galderisi M, Zito GA, Petrocelli
A, Carella C, et al. Plasma leptin level is associated with
myocardial wall thickness in hypertensive insulin-resistant
men. Hypertension.1999;34:1047-52.
16. Soderberg S, Ahren B, Jansson JH, Johnson 0, Hallmans G,
Asplund K, et al. Leptin is associated with increased risk of
myocardial infarction. J Intern Med.1999;246:409-18.
17. Pladevall M, Williams K, Guyer H, SadurniJ, Fakes C, Ribes
A, et al. The association between leptin and left ventricular
hypertrophy: a population-based cross-sectional study. J
Hypertens. 2003;21:1467-73.
18. Malmqvist K, Ohman KP, Lind L, Nystrom F, Kahan T.
Relationships between left ventricular mass and the reninangiotensin
system, cathecolamins, insulin and leptin. J
Intern Med. 2002;252:430-9
19. Lopez-Jimenez F, Cortes-Bergoderi M. Update: systemic
diseases and the cardiovascular system (i): obesity and the heart. Rev Esp Cardiol. 2011;64:140-9.
20. Stenvinkel P. Leptin and blood pressure-is there a link?
Nephrol Dial Transplant. 2000; 15:1115, 7.
21. Shek EW, Brands MW, Hall JE. Chronic leptin infusion
increases arterial pressure. Hypertension. 1998;94:409-14.
22. Hirose H, Saito I, Kawai T, Tsujioka M, Kawabe H, Saruta
T et al. Relationships between baseline serum leptin levels
and 2-year changes in body mass index, blood pressure and
metabolic parameters in Japanese male adolescents and
middle-aged men. Clin Sci (Lond). 2001; 100:145-50.
23. Lembo G, Vecchione C, Fratta L, Marino G, Trimarco V,
d'Amati G, et al. Leptin induces directvasodilation through
distinct endothelial mechanisms. Diabetes. 2000;49:293,
24. Almeida-Pititto B, Gimeno SG, Freire RD, Ribeiro-Filho
FF, Ferreira SR. Leptin is not associated independently with
hypertension in Japanese-Brazilian women. Braz J Med Biol
Res. 2006;39:99-105.
25. Avelar E, Cloward TY, Walker JM, Farney RJ, Strong M,
Pendleton RC, et al. Left ventricular hypertrophy in severe
obesity: interactions among blood pressure, nocturnal
hypoxemia, and body mass. Hypertension. 2007;49:34-9.
How to Cite
Kaunang D, Widodo H, Pateda V. Leptin, blood pressure, and left ventricular mass in obese adolescents. PI [Internet]. 30Dec.2013 [cited 25Jul.2024];53(6):346-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/375
Received 2016-08-30
Accepted 2016-08-30
Published 2013-12-30