Leptin, blood pressure, and left ventricular mass in obese adolescents

  • David Kaunang Department of Child Health, Sam Ratulangi University Medical School, Prof. Dr. R. D. Kandou Hospital
  • Handri Widodo Department of Child Health, Sam Ratulangi University Medical School, Prof. Dr. R. D. Kandou Hospital
  • Vivekenanda Pateda Department of Child Health, Sam Ratulangi University Medical School, Prof. Dr. R. D. Kandou Hospital
Keywords: Leptin, blood pressure, left ventricular mass, obesity

Abstract

Background Obesity is characterized by an excessive accumulation
of body fat and has become a major health problem in industrialized
societies especially with regards to heart disease. Adipose tissue
derived hormone (leptin) can cause obesity. Leptin acts to reduce
food consumption and enhance energy expenditure.
Objective To assess for a relationship between leptin, blood
pressure, and left ventricular mass in obese adolescents.
Methods This was a cross-sectional study conducted from
November 2011 to April 2012 in Prof. Dr. RD. Kandou Hospital.
This study included obese and healthy adolescents aged 13-18
years who attended school in Tuminting District ofManado. Each
subject underwent measurements of body mass index (BMI), boold
pressure, and plasma leptin level. Correlation regression test was
used for data analysis. Results were considered to be statistically
significant if P values < 0.05.
Results There was a significant relationship between leptin and
left ventricular mass (r=-0.467; P=0.006), as well as leptin and
systolic blood pressure (r=-0.366; P=0.028), but not between
leptin and diastolic blood pressure (r=-0.261; P=0.09). We also
found significant relationships between systolic blood pressure and
left ventricular mass (r=0.724; P<0.001), and between diastolic
blood pressure and left ventricular mass ( r=0.615; P< 0.001) in
obese adolescents.
Conclusion Higher leptin levels are associated with lower left
ventricular mass and lower systolic blood pressure, but are not
associated with diastolic blood pressure.

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Published
2013-12-30
How to Cite
1.
Kaunang D, Widodo H, Pateda V. Leptin, blood pressure, and left ventricular mass in obese adolescents. PI [Internet]. 30Dec.2013 [cited 17Apr.2024];53(6):346-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/375
Received 2016-08-30
Accepted 2016-08-30
Published 2013-12-30