Proteinuria and malaria parasite counts in children

  • Mahrani Lubis Department of Child Health, University of North Sumatera Medical School, H. Adam Malik Hospital
  • Rusdidjas Rusdidjas Department of Child Health, University of North Sumatera Medical School, H. Adam Malik Hospital
  • Rafita Ramayati Department of Child Health, University of North Sumatera Medical School, H. Adam Malik Hospital
  • Oke Rina Ramayani Department of Child Health, University of North Sumatera Medical School, H. Adam Malik Hospital
  • Rosmayanti S Siregar Department of Child Health, University of North Sumatera Medical School, H. Adam Malik Hospital
  • Supriatmo Supriatmo Department of Child Health, University of North Sumatera Medical School, H. Adam Malik Hospital
Keywords: proteinuria, malaria, Plasmodium f alciparum, kidney involvement

Abstract

Background Malaria-induced proteinuria has been observed in
severe cases of malaria. Few studies have been done to assess for
an association between proteinuria and malaria parasite counts
before the disease becomes severe.
Objective To investigate a possible association between proteinuria
and malaria parasite counts in children .
Methods A cross-sectional study was conducted on school-aged
children in Panyabungan, Mandailing Natal, between September
to November 2010. Malaria was diagnosed by microscopic
examination of peripheral blood smears. Children with malaria
underwent proteinuria t ests by urine dipstick method. An
association between proteinuria and malaria parasite counts was
analyzed using linear regression test.
Results Of 181 participants with Plasmodium fak:iparum malaria,
53.6% were female and had a mean age of 7.8 years. Subjects'
nutritional status were as follows: 50.8% normoweight, 28.2%
mild malnutrition, 3 .3% moderate malnutrition, and 17. 7% severe
malnutrition. Clinical manifestations showed 36.5% suffered from
subfebrile temperatures and 29.8% had pallor. Proteinuria occurred
in 45.9% participants and there was a weak association between
proteinuria and malaria parasite counts (raa .261, Paa .0001).
Conclusion There is a weak association between proteinuria and
malaria parasite counts in children.

References

1. Nand N, Aggarwal H, Sharma M, Singh M. Systemic
manifestations of malaria. J Indian Acad Clin Med.
2001;2:189-94.
2. Krogstad DJ. Plasmodium species (malaria). In: Mandell
GL, Bennett JE, Dolin R, editors. Principles and practice
of infectious diseases. 5th ed. Philadelphia: Churchill
Livingstone; 2000. p. 2817-30.
3. Badan Penelitian dan Pengembangan Kesehatan Depkes RI.
Riset kesehatan dasar (RISKESDAS) 2007: Laporan nasional
[serial on the internet]. [cited April 2010]. Available from:
http ://www. litbang. depkes. go. id/LaporanRKD/Indonesia/
laporanNasional.pdf.
4. Badan Penelitian dan Pengembangan Kesehatan Depkes
RI. Riset kesehatan dasar (RISKESDAS) 2007: Laporan
Provinsi Sumatera Utara [serial on the internet]. [cited
April 2010]. Available from: http://www.litbang.depkes.go.id/
LaporanRKD/Sumut/laporanSumut.pdf.
5. Pusat Penanggulangan Malaria Kabupaten Mandailing Natal.
Menuju Madina bebas malaria: Kantor Pusat Penanggulangan
Malaria; 2009.
6. van Velthuysen ML, Florquin S. Glomerulopathy associated
with parasitic infections. Clin Microbial Rev. 2000; 13:55-66.
7. Kashif W, Siddiqi N, Dincer HE, Dincer AP, Hirsch S.
Proteinuria: how to evaluate an important finding. Cleve
Clin J Med. 2003;70:535,47.
8. Fischbach IT, Dunning MB. A manual of laboratory and
diagnostic tests. 7,h ed. Philadelphia: Lippincott Williams &
Wilkins; 2004. p. 164-263.
9. Weber MW, Zimmermann U, van Hensbroek MB, Frenkel],
Palmer A, Ehrich JH, et al. Renal involvement in Gambian
298 • Paediatr Irulones, Vol. 53, No. 6, November 2013
children with cerebral or mild malaria. Trop Med Int Health.
1999;4:390,4.
10. Ogbadoyi EO, Gabi B. Assessment of renal function in malaria
patients in Minna, North Central Nigeria. Afr J Infect Dis.
2007;1:57-64.
11. Malaria. In: Soedarmo SSP, Gama H, Hadinegoro SRS, Satari
HI, editors. Buku ajarinfeksi &pediatri tropis. 2"d ed.Jakarta:
Badan Penerbit IDAI; 2008. p. 408-3 7.
12. Prakash], Gupta A, Kumar 0, Rout SB, Malhotra V, Srivas,
tava PK. Acute renal failure in falciparum malaria-increasing
prevalence in some areas of India-a need for awareness.
Nephrol Dial Transplant. 1996;11:2414-6.
13. Kanodia KV, Shah PR, Vanikar AV, Kasat P, Gumber
M, Trivedi HL. Malaria induced acute renal failure: a
single center experience. Saudi J Kidney Dis Transplant.
20 l 0;21: 1088-91.
14. Bouyou,Akotet MK, Dzeing-Ella A, Kendjo E, Etoughe
D, Ngoungou EB, Plauche T, et al. Impact of Plasmodium
falciparum infection on the frequency of moderate to severe
anaemia in children below 10 years of age in Gabon. Malar
J. 2009;8: 166.
15. Sitprija V. Nephropathy in falciparum malaria. Kidney Int.
1988;34:867, 77.
16. Das BS. Renal failure in malaria. J Vector Borne Dis.
2008;45:83-97.
17. Nguansangiam S, Day NP, Hien TT, Mai NT, Chaisri U,
Riganti M, et al. A quantitative ultrastructural study ofrenal
pathology in fatal Plasmodium falciparum malaria. Trop Med
Int Health. 2007;12:1037-50.
18. Sowunmi A. Renal function in acute falciparum malaria.
Arch Dis Child. 1996;74:293-8.
19. Ekeanyanwu RC, Ogu GI. Assessment of renal function
of Nigerian children infected with Plasmodium f alciparum.
IJMMS. 2010;2;251-5.
20. Raphael EC, Benjamin AU. Assessment of renal function of
Plasmodium falciparum infected children in Owetri, Eastern
Nigeria. ResJ Med Sci. 2010;4:208-12.
21. Subramanian K. Urine dipstick tests. BMJ. 2009;17:68-9.
22. Pati SS, Mishra SK. Can urine dipstick tests detect renal
impairment in Plasmodium f alciparum malaria in a rural setup?
Trop Doct. 2010;40:106-7.
23. Zamanzad B. Accuracy of dipstick urinalysis as a screening
method for detection of glucose, protein, nitrites and blood.
East Mediterr Health J. 2009;15:1323-8.
Published
2013-12-30
How to Cite
1.
Lubis M, Rusdidjas R, Ramayati R, Ramayani O, Siregar R, Supriatmo S. Proteinuria and malaria parasite counts in children. PI [Internet]. 30Dec.2013 [cited 17Apr.2024];53(6):295-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/310
Received 2016-08-21
Accepted 2016-08-21
Published 2013-12-30