Pyridoxine in the Treatment of Tetanus Neonatorum

Main Article Content

Musa Kazim Caglar

Abstract

A prospective study has been conducted to assess the efficacy of oral pyridoxine in the treatment of neonatal tetanus. A little reduction in mortality was observed by adding pyridoxine to the conventional therapy. The mortality in this group was 50.0% as compared to 62.5% in controls. This result did not confirm the ones in the literature. This could be sourced from the fact that additional injection was 50.0%.

Article Details

How to Cite
1.
Caglar M. Pyridoxine in the Treatment of Tetanus Neonatorum. PI [Internet]. 16Aug.2018 [cited 17Sep.2019];29(11-12):233-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1949
Section
Neonatology
Received 2018-08-16
Published 2018-08-16

References

1. BENECKE, R.; TAKANO, K.; SCHMIDT, J .: Tetanus toxin induced actions on spinal Renshaw cells and !a-inhibitory interneurons during development of local tetanus in the cat. Exp. Brain Res. 27: 271(1977).
2. DAUD, S.; MOHAMMAD, T.; AHMAD, A.: Tetanus neonatorum. J. trop. Pediat. 27: 308 (1981).
3.. EDWARDS, R.A.; JAMES, B.: Tetanus and psychiatry: Unexpected bed fellows . Med. J. Aust. l : 483 (1979).
4. GODEL, J.C.: Trial of pyridoxine therapy for tetanus neonatorum. J. infect. Dis. 145: 547 (1982).
5. GOLBRAITH, N.S.; FORBES, P.; TILLET, H.: National surveillance of tetanus in England and Wales. J. infect. Dis. 3: 181 (1981).
6. HAJAILAY, R.; SHARA, N.R.; AGARWAL, V.K.: Pyridoxine therapy in tetanus neonatorum. Indian. Pediatr. 20: 935 (1983).
7. SALIMPOUR, R.: Cause of death in tetanus neonatorum: Study of 233 cases with 54 necropsies. Arch. Dis. Child. 52: 587 (1977).
8. STEINER, F.A.: L-glutamic acid, gamma-aminobutyric acid and pyridoxal-5' -Phosphate at the level of the single. unit in rat brain. Ann. N.Y. Acad. Sci. 166: 199 (1969).
9. YALAZ, K.; HASANOGLU, E.:ยท Prognosis of tetanus neonatorum according to various methods of treatment. Proceedings XV International Congress of Pediatrics, 1978.