Clinical manifestation of drug allergy in children

  • Ariyanto Harsono Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
  • Anang Endaryanto Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
DOI: https://doi.org/10.14238/pi39.11-12.1999.325-9
Keywords: drug allergy, Steven Johnson syndrome, maculopapular rash, drug fever, fixed drug eruption

Abstract

In the period of January-December 18 cases of Drug Allergy were recognized, 4 cases from the allergy clinic, 8 cases were referred from outpatient clinic, 6 cases were referred from inpatient ward. The clinical manifestation varied from urticaria 5 cases (30%), Steven Johnson Syndrome 2 cases ( 12%), maculopapular rash 2 cases (12%), Drug fever 2 cases (12%), Fixed drug eruption 1 case (6%), exanthem 1 case (6%), Quinke's edema 5 cases (30%) consisted of 2 cases Quinke's edema only, 2 cases with urticaria, 1 case with drug fever. The underlying disease of these cases were upper respiratory tract infection 5 cases, chronic cough 2 cases, Asthma 5 cases, diarrhea 1 case cerebral abscess 1 case, Dengue Haemorrhagic Fever 1 case and Epilepsi 1 case. The mainstay of treatment was discontinuation of the offending drug. Drug substitution were given to patients nescessitated continuation of drugs, antihistamines were given to patients with urticaria and Quinke's edema. Two cases with Steven Johnson syndrome received supportive treatment and hydrocortisone intravenously.

References

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Published
1999-03-15
How to Cite
1.
Harsono A, Endaryanto A. Clinical manifestation of drug allergy in children. PI [Internet]. 15Mar.1999 [cited 25Apr.2024];39(11-12):325-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1810
Issue
Vol 39 No 11-12 (1999): November - December 1999
Section
Articles

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Received 2018-03-15
Accepted 2018-03-15
Published 1999-03-15