Renal tubular function of the child with thalassemia major who received repeated blood trransfusion
Keywords:
renal tubular function, thalassemia major, transfusion, desfenioxamine, radionuclide technique
Abstract
A descriptive study was done from December 2 , 1994 to January 5,1995, at the Department of Child Health of Hasan Sadikin General Hospital Bandung. A total of 50 thalassemia major patients who bad received 5,000 ml or more of blood transfusions and never received desfenioxamine underwent a renal tubular function test using a radionuclide technique (l-123 Hippuran) to determine the effective renal
plasmft flow (ERPF). The subjects were div:ided into two groups according to the amount of transfusion. Group A who received a total of 5,000 to 10,000 mL of blood transfusion consisted of 23 children (11 boys and 12 girls); group B, those who received a total of 10,000 ml or more of blood transfusion, consisted of 27 children (14 boys and 13 girls). The total average of blood transfused for group A and B were 7563.91 (1780.59) and 20,665.93 (6632.39) rnl, respectively. The ERPF of all subjects were below the normal standard. The average value of ERPF of group A and B were 205.78 (62 .08) and 214.09 (59.44) ml/minute/1.73 m2, respectively. The correlation between the total amount of blood transfusion and ERPF of the subjects was not significant (Group A had r=O.l63, p=0.458; Group B had r=0.084, p=0 .934).
References
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2. Mastrangello F et al. Function of the Kidney in adult patients with Cooley's disease. A preliminary report. Nephron 1975;14: 229-36.
3. Landing BH. Renal lesions and clinical fmdings in thalassemia major and other chronic anemias with hemosiderosis. Pediatr Pathol 1979; 9: 4 79-500.
4. Singadipoera BS dkk. Fungsi ginjal pada penderita thalassemia major yang mendapat transfusi berulang di Bagian Ilmu Kesehatan Anak FKUP /RSHS Bandung 1975.
5. Nicheles TF. Myocardial hemosiderosis in hypoxic mite. Ann NY Acad Sci 1969; 165:167-72.
Published
1999-08-30
How to Cite
1.
Hilmanto D, Singadipoera B, Ijradinata P. Renal tubular function of the child with thalassemia major who received repeated blood trransfusion. PI [Internet]. 30Aug.1999 [cited 23Nov.2024];39(7-8):193-00. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1770
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Received 2018-02-13
Accepted 2018-02-13
Published 1999-08-30
Accepted 2018-02-13
Published 1999-08-30
