Relationship of obesity and secondary sexual development in girls
Abstract
Background Obesity is a pathological condition due to consumption of excessive amount of food and is associated with early sexual maturation and irregular cycle of menstruation. Early sexual maturation is estimated from the age of menarche.
Objective To determine relationship of obesity and age of secondary sexual development in girls.
Methods This cross-sectional study was performed on all elementary school students in 4 sub-districts at Denpasar. Nutritional status was determined by BMI. Radiologic examination was performed to determine the bone age. Data were analyzed with appropriate statstical methods.
Results Mean chronological age of breasts development for B2 and B3 stage on obese group was younger than non-obese groups (9.0 vs 9.9, P = 0.001; 9.7 vs 10.9, P = 0.006). Early menarche more frequent in obese group than non-obese groups {PR 5 (CI 95% 1.33 to 19.71)}. Mean age of children who experienced menarche on obese group was younger than non-obese group {10.9(SD 0.61) vs 11.1 (SD 0.28). Univariate analysis showed that maturation age of secondary sexual development on obese groups was differed with non-obese group {8.9 (SD 0.21) vs 9.4 (SD 0.13). Linear regression analysis showed relationship between age of breasts and pubic hair growth on both groups.
Conclusions This study established that mean age of secondary sexual development was younger in obese girl than non-obese group. Bone age range on obese girls was wider than non-obese girls. [Paediatr Indones. 2010;50:49-5].
References
2. Lobstein T, Rigby N, Leach R. International Obesity Task Force. EASO. 2005; 1-4.
3. Suparyatha. Dyslipidaemia and influence factor of obesity in teenager at sub district of Denpasar. Cross sectional study [Thesis]. Denpasar: Department of Child Health, Medical School, Udayana University; 2004.
4. Maharditha IG. Lipid profil in children with obesity at Denpasar elementary school [Study report]. Denpasar: Department of Child Health, Medical School, Udayana University; 2005.
5. Schneider MB , Brill SR. Obesity in children and adolescent. Pediatr Rev. 2005; 26:155-62.
6. Soetjiningsih, Ranuh IGN. Obesitas pada anak. In: Soetjiningsih, editor. Tumbuh kembang anak. Jakarta: EGC, 1995; p. 183-91.
7. Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS. The relation of menarcheal age to obesity in childhood and adulthood: The Bogalusa Heart Study. BMBMC Pediatr. 2003; 3:1-9.
8. Lee PA, Guo SS, Kulin HE. Age of puberty: data from the United States of America. APMIS. 2001; 109:81-8.
9. Qamra SR, Mehta S, Deodhar SD. A mixed longitudinal study on the pattern of pubertal growth: relationship to socioeconomic status and caloric-intake-IV. Indian Pediatr. 1991; 28:147-56.
10. L Lazar L, Kauli R, Pertzelan A, Philip M. Gonadotropin-suppresive therapy in girl with early and fast puberty affect the pace of puberty but not total pubertal growth or final height. J Clin Endocrinol Metab. 2002; 87:2090-4.
11. Madiyono B, Moeslichan S, Sastroasmoro S, Budiman I, Purwanto SH. Perkiraan besar sampel. In: Sastroasmoro S, Ismael S, editors. Dasar-dasar metodologi penelitian klinis. Jakarta: Sagung Seto, 2002; p. 259-86.
12. Wang Y. Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls. Pediatrics. 2002; 110:903-10.
13. Widhi AN. Influence of obesity in growth and female secondary sexual development at elementary school in sub district of Surabaya. Cross sectional study [Thesis]. Surabaya: Child Health Department, Airlangga University; 2005.
14. Soetjiningsih. Pertumbuhan somatik pada remaja. In: Soetjiningsih, editor. Tumbuh kembang remaja. 1st ed. Jakarta: Sagung Seto, 2004; p. 1-2.
15. M Molina, PE. Female reproduction system. Endocrine physiology. New York: McGraw-Hill Companies, 2004; p. 207-42.
16. Anastasios P, Soula P, Konstandinos D, Dimitrios TP, Polyxeni N, Andreas F. Timing of pubertal onset in girls: evidence for non Gaussian distribution. J Clin Endocrinol metab. 2008; 93:4422-5.
17. Joyce ML, Danielle A, Niko K, Robert F, Bradley Robert HB, Julie CL. Weight status in young girls and the onset of puberty. Pediatrics. 2007; 119:624-30.
18. Himes JH, Obarzanek E, Baranowski T, Wilson DM, Rochon J, Clanahan BS. Early sexual maturation, body composition and obesity in African-American girls. Obes Res. 2004; 12(Suppl):64S-72S.
19. Sumiartini. Relationship between nutritional status and maturity of puberty among elementary school children [Study report]. Denpasar: Department of Child Health, Medical School, Udayana University; 2004.
20. Lee, PA, Kulin, HE. Normal pubertal development. In: Moshang T, editor. Pediatric endocrinoloy: the requisites in pediatrics. Philadelphia: Elsevier Mosby, 2005; p. 63-71.
21. Needleman, R.D. Growth and development. In: Behrman RE, Kliegman R, Arvin AM, editors. Nelson textbook of pediatrics. 17th ed. Philadelphia: WB Saunders Company, 2004; p. 23-66.
22. Mul D, Fredriks AM, Van Buuren S, Oostdjik,Verloove- Vanhorick SP, Wit JM. Pubertal development in the Netherlands 1965-1997. Pediatr Res. 2001; 50:479-86.
23. Klein KO, Larmore KA, Lancey E, Brown JM, Considine RV, Hassink SG. Effect of obesity on estradiol level, and its relationship to leptin, bone maturation, and bone mineral density in children. J Clin Endocrinol Metab. 1998; 83:3469-75.
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Accepted 2016-08-15
Published 2010-03-03