C3 and C4 Complements in Glomerular Disorders in Children

H. Alatas; I.G.N. Wila Wirya; T. Tambunan

doi:10.14238/pi18.3-4.1978.75-82

H. Alatas Department of Child Health, Medical School, University of Indonesia, Jakarta.
I.G.N. Wila Wirya Department of Child Health, Medical School, University of Indonesia, Jakarta.
T. Tambunan Department of Child Health, Medical School, University of Indonesia, Jakarta.

DOI: https://doi.org/10.14238/pi18.3-4.1978.75-82

Keywords: c3, c4, glomerular

Abstract

Seventy children who were hospitalized for kidney diseases in the Nephrological ward Department of Child Health, University of Indonesia, Jakarta were used in this study. Thirty seven patients sufferfng from acute poststreptococcal Glomerulonephritis (A.G.N.), 3 patients with Membranoproliferative Glomerulonephritis (M.P.G.N.) and 30 patients with Nephrotic Syndrome due to other causes were examined for complement concentration. A total of 80 samples were examined for C3 and 25 samples for C4 concentration using the immunediffusion plates. Almost all patients with A.G.N. and M.P.G.N. showed depression of C3. C4 concentration was normal except in 2 patients, 1 with A.G.N. and the other With M.P.G.N. This suggest activation of complement at the C3 level by the alternating pathway in most of the patients. C3 concentration in A.G.N. patients returned to normal after 8-10 weeks. In MPGN the depression was persistent in 2 patients, while in 1 patient it returned to normal level after 3 months of Immunosuppressive treatment.

References

BLACK, J.A., CHALLACOMBE, D.N. and ACKENDEN, E.G. : Nephrotic syndrome associated with bacteremia after shunt operation for hydrocephalus. Arch. Int. med. 125 : 322 (1970).

BRANDIS, M., KROHN H.P. and STERZEL, R.B. : C3 - Komplement bei glomerularen Erkrankungen inn Kindesalter. Mschr. Kinderheilk. 123 : 421 (1975).

CAMERON, J.S., GLASCOW, E.F., OGG, C.S. and WHITE, R.H.R. : Membrano proliferative glomerulonephritis and persistent hypocomplementemi11. Br. Med. J. 4 : 7 (1970).

CAMERON, J.S., VICK, R.M., OGG, C.S., SEYMOUR, W.M., CHANTLER, C. and TURNER, D.R. : Plasma C3 and C4 concentrations in Management of Glomerulonephritis. Brit. med. J. 3-668 (1973).

DODGE, W.F., SPARGO, B.H., TRAVIS, L.B., SRIVASTAVA, R.N., CARNAJAL, H.F., DE BEUKELAER, M.M., LONGLEY, M.P. and MENCHACA, J.A. : Post streptococcal glomerulonephritis: a prospective study in children. New Eng. J. med. 286 : 273 (1972).

GEWURZ, H., PICKERING, R.J., MERGEN HAGEN, S.E. and GOOD, R.A. : The complement profile in acute glomerulonephritis, systemic lupus erythematosus and hypocomplementemic chronic glomerulonephritis: contrasts and experimental correlation. Int. Arch. Allergy 34 :Â· 556 (1968).

GEWURZ, H. in Ingram's Biological Activities of Complement p. 56. (Karger, Basel 1971).

HERDMAN, R.C., PICKERING, P.J., MICHAEL, A.F., VERNIER, R.L., FISH, A.J., GEWURZ, H. and GOOD, R.A. : Chronic glomerulonephritis associated with low serum complernent activity. Medicine 49 : 207 (1970).

OGG, C.S., CAMERON, J.S. and WHITE, R.H.R. : The C3 component of complement (beta 1 C - globulin) in patient with heavy proteinuria. Lancet. 2 : 68 (1968).

SPITZER, R.E., VALLOTA, E.H., FORRISTAL, J., SUDORA, E., STITZEL, A., DAVIS, N.C. and WEST C.D. : Serum C3 Lytic System in patients with glomerulonephritis. Science 164 : 436 (1969).

VALLOTA, E.A., FORRISTAL, J., SPITZER, R.E., DAVIS, N.C. and WEST, C.D. : Characteristics of a non-complement-dependent C3-reactive complex formed from factors in nephritic and normal serum. J. Clin. Invest. 131 : 1306 (1970).

WEST, C.D., NORTH WAY, J.D. and DAVIS, N.C. : Serum levels of B1 C - globulin, a complement component, in the nephritides, Lipoid nephrosis and other conditions J. clin. Invest 43 : 1507 (1964).