Management of vaccination - related anaphylaxis

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Ariyanto Harsono


Anaphylaxis is a systemic, immediate hypersensitivity reaction due to IgE mediated immunologic release of
mediators from mast cells and basophils. Features of severe condition are obstruction of the upper airway from tissue
swelling, marked bronchospasm, and hypotension. In vaccination related anaphylaxis, optimal management begins with
prevention: prevaccination screening including questions about possible allergy to any component of vaccine, and anticipation
of anaphylaxis by observation at least 15 minutes following vaccination are very important. The essential treatment is
prompt administration of adrenaline. Since hypotension is due to a shift of fluid from intravascular to extravascular space, the
mainstay of treatment should be the restoration of intravascular volume. Since anaphylaxis can be biphasic administration of
corticosteroid in preventing late phase reaction can be postulated.

Article Details

How to Cite
Harsono A. Management of vaccination - related anaphylaxis. PI [Internet]. 30Apr.2001 [cited 14Nov.2019];41(3-4):96-9. Available from:
Received 2017-02-01
Accepted 2017-02-01
Published 2001-04-30


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