High sensitivity C-reactive protein, left ventricular mass, and systolic function in obese adolescents

  • Erling David Kaunang Department of Child Health, Sam Ratulangi University Medical School, Manado.
  • Suryani As’ad Department of Child Health, Hasanuddin University Medical School, Makassar.
  • Sarah M. Warouw Department of Child Health, Sam Ratulangi University Medical School, Manado.
  • Peter Kabo Department of Child Health,Hasanuddin University Medical School, Makassar.
DOI: https://doi.org/10.14238/pi56.2.2016.124-8
Keywords: hs-CRP, left ventricular mass, left ventricular function, obesity

Abstract

Background Obesity has been associated with structural and functional cardiac muscle defects. High sensitivity C-reactive protein (hs-CRP) has been utilized as an independent predictor of future cardiovascular disease.
Objective To assess for correlations between hs-CRP, left ventricular mass, and systolic function in obese adolescents.
Methods This cross-sectional study was conducted from August 2013 to February 2014. Subjects were obese adolescents aged 13-18 years with a body mass index (BMI) >95th percentile, according to the 2000 Centers for Disease Control and Prevention Growth Chart. Subjects underwent laboratory testing of serum hs-CRP levels, as well as left ventricular mass and function measurements by echocardiography. Descriptive analysis was performed on patients’ characteristics and correlation analysis was done by Pearson’s test with a significance level of P<0.05.
Results Subjects were 40 obese adolescents. There was no statistically significant correlation between hs-CRP and left ventricular mass (r=0.083; P=0.305). There was a moderate correlation between hs-CRP with ejection fraction (EF) (r=0.372 and P=0.009 ) and fractional shortening (FS) of the left ventricle (r=0.420 and P=0.003).
Conclusion In obese adolescents, we find no correlation between hs-CRP and left ventricular mass. However, hs-CRP is moderately correlated with left ventricular EF and FS.

References

1. Fox E, Taylor H, Andrew M, Han H, Mohamed E, Garrison R, et al. Body mass index and blood pressure influences on left ventricular mass and geometry in African Americans: The Atheroscerotic Risk in Communities (ARIC) Study. Hypertension. 2004;44:55-60.
2. Marinov L. Changes in the left ventricular muscle mass in adolescents. J IMAB. 2009.16-8.
3. Eraky AZE. Assessment of carotid intima-media thickness and LV structure and function in obese adolescents [thesis]. [Arabia]: Suez Canal University. 2011.
4. Hanevold C, Waller J, Daniels S, Portman R, Sorof J. The effects of obesity, gender and ethnic group on left ventricular hypertrophy and geometry in hypertensive children: a collaborative study of the International Pediatric Hypertension Association. Pediatrics. 2004;113:328-32.
5. Halenka M. Noninvasive measurement of early atherosclerosis by high resolution B-mode ultrasonography. Acta Univ Palacki Olomuc Fac Med.1999;142:7-11.
6. Sastroasmoro S. Ekokardiografi. In: Sastroasmoro S, Mardiyono B. editors. Buku ajar kardiologianak. Jakarta: BinarupaAksara; 1994.p.103-26.
7. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561-6.
8. Verma S, Buchanan MR, Anderson TJ. Endothelial function testing as a biomarker of vascular disease. Circulation. 2003;108:2054-9.
9. Abraham J, Campbell CY, Cheema A, Gluckman TJ, Blumenthal RS, Danyi P. C-reactive protein in cardiovascular risk assessment: a review of the evidence. J Cardiometab Syndr. 2007;2:119-23.
10. al-Nuaim AR, Bamgboye EA, al-Herbish A. The pattern of growth and obesity in Saudi Arabian male school children. Int J ObesRelatMetabDisord. 1996;20:1000-5.
11. Sjarif DR. 2011. Obesitas anak dan remaja. In: Sjarif DR, Lestari ED, Mexitalia M, Nasar SS. editors. Nutrisipediatrik dan penyakit metabolik. 1st ed. Jakarta: Ikatan Dokter Anak Indonesia. p.230-43.
12. Sjarif DR, Nasar SS. Obesitas. In: Pudjiadi AH, Hegar B, Handyastuti S, Idris NS, Gandaputra EP, Harmoniati ED,editors. Pedoman pelayanan medis. Jakarta: Ikatan Dokter Anak Indonesia; 2010.p.197-204.
13. Simsek E, Balta H, Balta Z, Dallar Y. Childhood obesity-related cardiovascular risk factors and carotid intima-media thickness. Turk J Pediatr. 2010;52:602-11.
14. Stabouli S, Kotsis V, Karagianni C, Zakopoulos N, Konstantopoulos A. Blood pressure and carotid artery intima-media thickness in children and adolescents: the role of obesity. Hellenic J Cardiol. 2012;53:41- 7.
15. Rider OJ, Francis JM, Ali MK, Byrne J, Clarke K, Neubauer S, et al.Determinants of left ventricular mass in obesity: a cardiovascular magneticresonance study. JCardiovascMagnRes. 2009;11:1-14.
16. Ghanem S, Mostafa M, Ayad S. Early echocardiography abnormalities in obese children and adolescent and reversibility of these abnormalities after significant weight reduction. J Saudi Heart Assoc. 2010;22:13-8.
17. Hariyanto D, Madiyono B, Sjarif DR, Sastroasmoro S. Hubunganketebalantunika intima media artericarotisdenganobesitaspadaremaja. Sari Pediatri. 2009;113:159-67.
18. Reinehr T, Wunsch R.Intima media thickness-related risk factors in childhood obesity. Int J Pediatr Obes. 2011;6Suppl 1:46-52.
19. Steinberger J, Daniels SR. Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation. 2003;107:1448-53.
20. Guardamagna O, Abello F, Saracco P, Baracco V, Rolfo E, Pirro M. Endothelial activation, inflammation and premature atherosclerosis in children with familial dyslipidemia. Atherosclerosis. 2009;207:471-5.
21. Ridker PM. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation. 2001;103:1813-8.
Published
2016-07-19
How to Cite
1.
Kaunang ED, As’adS, Warouw SM, Kabo P. High sensitivity C-reactive protein, left ventricular mass, and systolic function in obese adolescents. PI [Internet]. 19Jul.2016 [cited 22Nov.2024];56(2):124-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/121
Issue
Vol 56 No 2 (2016): March 2016
Section
Pediatric Cardiology

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Received 2016-07-19
Accepted 2016-07-19
Published 2016-07-19