High sensitivity C-reactive protein, left ventricular mass, and systolic function in obese adolescents

Main Article Content

Erling David Kaunang
Suryani As’ad
Sarah M. Warouw
Peter Kabo


Background Obesity has been associated with structural and functional cardiac muscle defects. High sensitivity C-reactive protein (hs-CRP) has been utilized as an independent predictor of future cardiovascular disease.
Objective To assess for correlations between hs-CRP, left ventricular mass, and systolic function in obese adolescents.
Methods This cross-sectional study was conducted from August 2013 to February 2014. Subjects were obese adolescents aged 13-18 years with a body mass index (BMI) >95th percentile, according to the 2000 Centers for Disease Control and Prevention Growth Chart. Subjects underwent laboratory testing of serum hs-CRP levels, as well as left ventricular mass and function measurements by echocardiography. Descriptive analysis was performed on patients’ characteristics and correlation analysis was done by Pearson’s test with a significance level of P<0.05.
Results Subjects were 40 obese adolescents. There was no statistically significant correlation between hs-CRP and left ventricular mass (r=0.083; P=0.305). There was a moderate correlation between hs-CRP with ejection fraction (EF) (r=0.372 and P=0.009 ) and fractional shortening (FS) of the left ventricle (r=0.420 and P=0.003).
Conclusion In obese adolescents, we find no correlation between hs-CRP and left ventricular mass. However, hs-CRP is moderately correlated with left ventricular EF and FS.

Article Details

How to Cite
Kaunang ED, As’ad S, Warouw SM, Kabo P. High sensitivity C-reactive protein, left ventricular mass, and systolic function in obese adolescents. PI [Internet]. 19Jul.2016 [cited 29Jan.2020];56(2):124-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/121
Pediatric Cardiology
Received 2016-07-19
Accepted 2016-07-19
Published 2016-07-19


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