Loperamide for acute diarrhoea in infancy (a clinical experience)

  • Pitono Soeparto Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
  • Liek Djupri Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
  • Hardjono Soeparto Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
  • Haroen Noerasid Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
DOI: https://doi.org/10.14238/pi21.5-6.1981.115-8
Keywords: loperamied, acute diarrhoea, acute maetry diarrhoea, oral glucose electrolyte solutuion

Abstract

A total of 94 infants aged below 3 years with acute maetry diarrhoea underwent treatment with loperamide (Normotil, Pharos Indonesia). They were arbitarily divided into group I (46 patients) receiving loperamide and group II (48 patients) receiving loperamide & antibiotics in addition to oral glucose-electrolyte solution. Stools became normal within 3 days in 69.6% of patients in group I and 86% in group 11, and within 7 days in 87% of patients in group 1 and 95.4% in group Il. In 5 patients, diarrhoea worsened within 24 hours, necessitating the administration of i.v.f.d. There were no side-effects encountered during the treatment of loperamide.

References

1. AMERY, W., DUYCK, F., POLAK, J. and BOUWHUYSEN, G.Y. "A Multicentre Double Blind Study" in acute diarrhea. Current Therapeutic Research 17: 263 (t975).
2. CONNEL, A.M. et al. : Loperamide in acute and chronic diarrhoea. Medical Progress, Vol. : 23 (1980).
3. CORNETT, IW.D. et al. : Diarrhoea: loperamide is better. Current therapeutic Research 21 : 629 (1977),
4. GALAMBOS, J.T., HERSH, T., SCHRODER, S. and WENGER, J. : Loperamide: a new antidiarrheal agent in the treatment of chronic diarrhea. Gastroenterology 70 : 1026 (1976).
5. VANAPRUKS, Y., TAWEEWUTHRISUL, W., SIMASATHIEM, S. and DUANG MANE. J. : Loperamide: an effective drug for acute diarrhea in children. Third Asian Congress of Paediatrics, Bangkok, November 1979.
Published
1981-06-30
How to Cite
1.
Soeparto P, Djupri L, Soeparto H, Noerasid H. Loperamide for acute diarrhoea in infancy (a clinical experience). PI [Internet]. 30Jun.1981 [cited 20Apr.2024];21(5-6):115-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1168
Issue
Vol 21 No 5-6 (1981): May - June 1981
Section
Articles

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Received 2017-01-19
Accepted 2017-01-19
Published 1981-06-30