Rapid improvement of respiratory quality in asthmatic children after "assisted drainage" therapy

Main Article Content

Haryono Utomo
Ariyanto Harsono


Background  Whilst current asthma management is well-developed, there are still 5-10% uncontrolled asthma patients with unknown etiologies. However, its connection with oral focal infection is still uncertain. Therefore, a collaborated research for asthma management was conducted by pediatricians and dental practitioners. Within minutes after the "assisted drainage" therapy, a modification of healing root planning procedure, there is rapid improvement of respiratory function, ie., forced expiratory-volume one second (FEV1) in asthmatic children. This quick response usually achieved by oral inhalation.

Objective To investigate the effectiveness of the assisted drainage therapy in the improvement of respiratory quality.

Methods Fifteen asthmatic children were subjected to a longitudinal study for two weeks. In tbe first week they were instructed for al lergen avoidance only and the fOllowing one week was combined with tbe assisted drainage therapy, followed by  mental health education and dental plaque control therapy. Each s'ubject was af'sef'sed for respiratory quality with a computerized spirometer and blood sampling test. Paired t-test analysis was used for statistical analysis.

Results Assisted drainage therapy was performed, within minutes FEV1 increased significantly (P= 0.001). Additionally, there were significant differences serum histamine (P= 0,001) pre and post treatment.

Conclusions The assisted drainage therapy is effective as an adjuvant therapy for mild persistent asthma in children.

Article Details

How to Cite
Utomo H, Harsono A. Rapid improvement of respiratory quality in asthmatic children after "assisted drainage" therapy. PI [Internet]. 30Aug.2010 [cited 16Aug.2020];50(4):199-06. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1055
Received 2016-11-18
Accepted 2016-11-18
Published 2010-08-30


1. Rahajoe N, Supriyatno B, Setyanto DB. Pedoman nasional asma anak. 1st ed. Jakarta: UKK Pulmonologi; 2005. p.1-15.
2. Strek ME. Difficult asthma. Proc Am Thorac Soc. 2006;20:120-3.
3. Eder W, Ege MJ, Mutius E. Asthma epidemic. NEJM. 2006;355:2226-35.
4. Li XJ, Kolltveit KM, Tronstad L, Olsen L. Systemic diseases caused by oral infection. Clin Microb Rev. 2000;13:547-58.
5. Seymour GJ, Ford PJ, Cullinan MP, Leishman S, Yamazaki K. Relationship between periodontal infections and systemic diseases. Clin Microbiol Infect. 2007;13 (SuppI4):3-10.
6. Martinez FD. Managing childhood asthma: challenge of preventing exacerbation. Pediatrics. 2009;123:S146-S150.
7. Gupta RS, Weiss KB. The 2007 National Asthma Education and Prevention Program Asthma Guidelines: Accelerating their implementation and facilitating their impact on children with asthma. PetuatTics. 2009;123:S193-S198.
8. Romagnani S. The increased prevalence of allergy and the hygiene hypothesis: misf'ing immune deviation, reduce immune suppression, or both? J Allergy Clin Immunol 2004;112:352-63.
9 . Arbes SJ, Sever ML, Vaughn B, Eric A, Cohen EA, Lxldin DC. Oral pathogens and allergic disease: results trom the third national health and nutrition examination survey.)
Allergy Clin ImmunoL 2006;118:1169-75.
10. Friedrich N, Volzke H, Schwahn C, Kramer A, Junger M, Scbafer T et al. Inverse association between periodontitis and respiratory allergies. Clin Exp Allergy. 2006;36:495-502.
11. Steinbacher DM, Glick M. The dental patient with asthma: an update and oral health considerations. J Am Dent Assoc. 2001;132:1229-39.
12. Utomo H. Management of oral focal infection in patients with asthmatic symptoms. Dent J (Majalah Kedokteran Gigi). 2006;39:120-5.
13. Utomo H. The oral health-asthma prevention program: an integrated study in behavioral intervention and children's immunity. J Indones Dent Assoc. 2007;5-10.
14. Utomo H, Pradopo S. Practical dental approach in children's rhinosinusitis management. J Dentistry. 2006;13:133-6.
15. Wiyarni, Sudiatmika N, Febiola I, Utomo H, Harsono A. The effect of dental plaque control therapy towards respiratory quality in allergic asthmatic children. [thesis]. Surabaya: Department of Child Health, Faculty of Medicine, Airlangga University; 2007.
16. Lundy W, Linden R. Neuropeptides and neurogenic mechanism in oral and periodontal inflammation. Crit Rev Oral Biol. 2004;15:82-98.
17 Yaprak M. The axon reflex. Nemoanatomy. 2008;7:17-9.
18. Lemeshow S, Hosmer DW Jr, KIar J, Lwanga SK. Adequacy of sample size in health studies. Chichester: John Wiley & Sons; 1990.
19. Amaral MM, Davio C, Ceballos A, Salamone G, Canones C, Jorge Geffner et al. Histamine improves antigen uptake and cross-presentation by dendritic cells. J ImmunoL 2007;179: 425-33.
20. Parsons ME, Ganelli CR. Histamine and its receptors. Br J Pharm.2006;147:S127-S135.
21. Cady RK, Schreiber CF. Sinus headache or migraine. Neurology. 2002;58:S10-S14.
22. Okeson JF. Bell's Orofacial Pain. 6th ed. Carol Stream: Quintessence Publ; 2005.
23. Klinghardt DK. The sphenopalatine ganglion (SPG) and environmental sensitivity. Lecture on 23rd Annual Intetuational Symposium on Man and His Environment; 2005 June 9-12;. Dallas, Texas.
24. Chih-Feng T, Baraniuk JN. Upper airway neurogenic mechanisms. Cur Al Clin Immunol. 2002;2:11-9.
25. Serrano C, Valero A, Picado C. Rhinitis and asthma: one airway, one disease. Arch Bronnconeomol. 2005;41:569-78
26. LJ tomo H. The immunonemomodulatory effect of the assisted drainage therapy towards allergic rat induced with Porphyromonas gingivalis lipopolysaccharide: an experimental laboratory study. [PhD thesis]. Surabaya: Airlangga University; 2009.
27. Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. 6th ed. Philadelphia: Saunders-Elsevier; 2007.
28. Ali H, Panettied RA. Anapbylatoxin C3a receptor in asthma. Respir Res. 2005;6:19-24.
29. Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutrition. 2007; 85:1185-96.
30. Platts-Mills TAE. Tbe role of immunoglobulin E in allergy and asthma. Am.J Respir Crit Care Med. 2001;204 (Suppl):1-5.
31. Lanier BQ, Chang TW, 2004. Will anti-IgE tberapy compromise normal immune functions? Allergy Clin Immunol lnt. 2004;20:1-4.