Incidence of neonatal hyperbilirubinemia in low, intermediate-low, and intermediate-high risk group infants
Abstract
Background Neonatal hyperbilirubinemia is commonly found in newborns. Assessment of the risk of hyperbilirubinemia and information on the average time of the occurrence of hyperbilirubinemia are important to prevent the development of severe hyperbilirubinemia.
Objective To find out the incidence of and the time of the development of hyperbilirubinemia in healthy-term newborns.
Method A cohort prospective study was done on healthy-term newborns born at Hasan Sadikin Hospital between November and December 2009. Subjects were divided into 4 groups of risk at discharged, based on Bhutani nonnogram. A serial bilirubin level measurement were perfonned within 6 days.
Resu l ts One of 14 newborns at low risk group developed hyperbilirubinemia but did not need phototherapy. Six of 14 newborns at intermediate-low risk group developed hyperbilirubinemia, 2 of them needed phototherapy with total serum bilirubin level of 14.7 mg/dL at 57 hours and 19.8 mg/dL at
111 hours. Nine of 15 newborns of intennediate-high risk group developed hyperbilirubinemia, 1 of them needed phototherapy with total serum bilirubin level of 16.6 mg/dL at 76 hours. There was no newborn cathegorized as high risk group in this study. The median time the occurrence of hyperbilirubinemia in intennediate-low and intennediate-high risk group was 140 hours and 82 hours, respectively. There was no significant difference in survival curve between intennediate-high and intennediate-low risk groups (95% CI 108.1 to 1 2 5.4).
Conclusion The incidence of hyperbilirubinemia was not different between intennediate-low and intermediate-high risk babies.
References
2. Madan A, MacMahon JR, Stevenson DK. Neonatal hyperbilirubinemia. In: Taeusch HW, Ballard RA, Gleason CA, editors. Avery's diseases of the newoorn. 8th ed. Philadelphia: WB Saunders Co, 2005; p. 1226-53.
3. Martin CR, Cloherty JP. Neonatal hyperbilirubinemia. In: Cloherty JP, Eichenwaald EC, Stark AR, editors. Manual of neonatal care. 5th ed. Philadelphia: Lippincott Williams & Willkins; 2004. p. IS5-221.
4. Wong RJ, De Sandre GH, Sibley E, Stevenson DK. Neonatal jaundice and liver disease. In: Martin RJ, Fanaroff AA, Walsh MC, editors. Fanaroff & Martin's neonatal perinatal medicine. 8th ed. Philadelphia: Mosby Elsevier; 2006. p. 1419-61.
5. Alpay F, Sarici SU, Tosuncuk HD, Serdar MA, Inanc N, Gokcay E. The value of first-day bilirubin measurement in predicting the development of significant hyperbilirubinemia in healthy tenn newborns. Pediatrics. 2000;106:eI6.
6. Gomella TL, Cunningham D, Eyal FG, Zenk KE. Hyperbilirubinemia. Neonatology: management, procedures, onô€call problems, diseases and drugs. 5th ed. New York: McGraw-Hill; 2003. p. 3S1-95.
7. Seidman DS, Stevenson DK, Ergaz Z, Gale R. Hospital readmission due to neonatal hyperbilirubinemia. Pediatrics. 1995;96:727-9.
8. Stevenson DK, Fanaroff AA, Maisels MJ, Young B\vy, Wong RJ, Vreman HJ, et al. Prediction of hyperbilirubinemia in near-term and term infants. J Perinatol. 2001;21:S63-72.
9. Keren R, Bhutani VK. Preô€discharge risk assessment for severe neonatal hyperbilirubinemia. Neonatol Rev. 2007;8:e68-77.
10. Bhutani VK, Johnson L. Managing the assessment of neonatal jaundice: importance of timing. Indian J Pediatr. 2000;67:733-S.
11. Newman TB, Litjestrand P, Escobar GJ. Combining clinical risk factors with serum bilirubin level to predict hyperbilirubinemia in newborns. Arch Pediatr Adolesc Med. 2005;159:113-9.
12. Mukherjee S, Ozden N. Hyperbilirubinemia: unconjungated. ©2009 [cited 2010 Feb 23]. Available from http://www. rnedscape.com.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Accepted 2016-10-20
Published 2016-10-26
