Correlation between lipid profile and C-reactive protein in children with nephrotic syndrome

Main Article Content

Kurnia Dwi Astuti
Mohammad Heru Muryawan
Omega Mellyana

Abstract

Background Nephrotic syndrome (NS) causes dyslipidemia in children, which can be long term or intermittent. Dyslipidemia has long been established as a risk factor for atherosclerosis. An early sign of atherosclerosis is elevated high sensitivity C-reactive protien (hsCRP). Atherosclerosis early in life, especially in childhood, warrants an assessment for NS. Study on a correlation between lipid profile and hsCRP, as a marker of atherosclerosis, in pediatric NS patients has been limited. Objective To assess for a correlation between lipid profile and hsCRP in childhood nephrotic syndrome. Methods This cross-sectional study was undertaken on 29 children with NS in Dr. Kariadi Hospital. Serum hsCRP, total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were examined in the active phase. Spearman’s test was used to analyze a possible correlation between total cholesterol, LDL, HDL and hsCRP levels. Results Mean levels of total cholesterol (454 mg/dL) and LDL (288 mg/dL) in this study were high, while the HDL level (55 mg/dL) was normal, according to US Department of Health and Human Services classifications. The median hsCRP level was 0.33 mg/L and 9 (31%) subjects had high hsCRP levels of more than 1 mg/L. There was a positive correlation between LDL level and hsCRP (r=0.423; P<0.05). Conclusions There is a weak positive correlation between LDL and hsCRP levels in children with NS.

Article Details

How to Cite
1.
Astuti KD, Muryawan MH, Mellyana O. Correlation between lipid profile and C-reactive protein in children with nephrotic syndrome. PI [Internet]. 1Mar.2015 [cited 22Sep.2019];55(1):1-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/97
Section
Articles
Received 2016-07-12
Accepted 2016-07-12
Published 2015-03-01

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