Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children

  • Laily Munawwarah Department of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North Sumatera
  • Rita Evalina Department of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North Sumatera
  • Sri Sofyani Department of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North Sumatera
DOI: https://doi.org/10.14238/pi57.5.2017.234-8
Keywords: atopic dermatitis, vitamin D, children

Abstract

Background Vitamin D plays an important role in the immune system. It inhibits B-lymphocyte proliferation and modulates the humoral response to suppress IgE production. Studies on the relationship between serum 25-hydroxyvitamin-D level and the severity of atopic dermatitis in several countries have had varying results.

Objective To assess for a possible correlation between serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children.

Methods A cross-sectional study was conducted in 26 children with atopic dermatitis from September to December 2015. We evaluated the severity of disease using the Scoring of Atopic Dermatitis (SCORAD) index and measured serum 25-hydroxyvitamin-D levels. Spearman’s test was used to analyze for a correlation between serum 25-hydroxyvitamin-D level and the atopic dermatitis  score in children with atopic dermatitis.

Results Mean SCORAD index was 32.0 (SD 14.99) , with a range of 10.9 to 71.4. Mean serum 25-hydroxyvitamin-D level was 41.1 (SD 24.81) ng/mL, with a range of 10-137 ng/mL. There was a moderate correlation between serum 25-hydroxyvitamin-D level and the SCORAD index (r=-0.591), with higher SCORAD index associated with lower serum 25-hydroxyvitamin-D level (P=0.01).

Conclusion There is a moderate correlation between serum 25-hydroxyvitamin-D level and the SCORAD index in children with atopic dermatitis.

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Published
2018-01-05
How to Cite
1.
Munawwarah L, Evalina R, Sofyani S. Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children. PI [Internet]. 5Jan.2018 [cited 22Nov.2024];57(5):234-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/965
Issue
Vol 57 No 5 (2017): September 2017
Section
Articles

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Received 2016-10-18
Accepted 2017-10-16
Published 2018-01-05