HLA-B60 and HLA-DR4 alleles in Javanese children with steroid-sensitive primary nephrotic syndrome
Keywords:
steroid-sensitive nephrotic syndrome-HLA type B60-DR4, case-control study
Abstract
Background Steroid-sensitive nephrotic syndrome (SSNS) ofchildren is associated with several human leucocyte antigen (HLA)
class I and class II.
Objective To investigate the association between HLA-B60 and
HLA-DR4 alleles and primary nephrotic syndrome (PNS) in
Javanese children.
Methods A case control study was conducted on 47 Javanese
children with PNS who were typed for HLA-B60 and HLA-DR4 al-
leles, using DNA sequence specific oligonucleotide probe (SSOP)
as control sample, 47 healthy children were also typed for those
HLA antigens using the same technique.
Results Compared with control group, children with PNS had higher
frequency of both HLA-B60 (23.32% vs 4.3%; OR=6.85 [CI=1.32-
35.65]; P<0.01) and HLA-DR4 (40.0% vs 2.1%; OR=30.67 [CI:3.71-
253.33]; P<0.0002). There was association between HLA and PNS
with SSNS in children.
Conclusion The strong association between PNS and HLA anti-
gen support the immunogenetic background of the disease, which
seems to be stronger in young children with SSNS.
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MP, Meissner J, et al. HLA- class II association with
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nephrotic syndrome. Dekker, New York; 1988. p. 163-93.
2. Thomson G. HLA disease association: Models for the
study of complex human genetic disorders. Crit rev
Clin Lab Sci 1995;32:183-219.
3. Thomson PD, Barratt TM, Stokes CR, Turner MW,
Soothill JF. HLA antigen and atopic feature in ste-
roid-responsive nephrotic syndrome of childhood. Lan-
cet 1976;9:765-8.
4. Hoeffner A, Abbal M, Mytilineos J, Konrad M, Kramer
I, Bouissou F, et al. Oligotyping for HLA-DQA, -DQB,
and -DPB in idiopathic nephrotic syndrome. Pediatric
Nephrol 1997;11:291-5.
5. De Mouzon-Cambon A, Bouisssou F, Dutau G, Barthe
P, Parra MT, Sevin A, et al. HLA-DR7 in children with
idiopathic nephrotic syndrome. Correlation with atopy.
Tissue antigens 1981;17:518-24.
6. Bouissou F, Meissner I, Konrad M, Somner E,
Mytilineos J, Ohayon E, et al. Clinical implications from
studies of HLA antigens in idiopathic nephrotic syn-
drome in children. Clin Nephrol 1995;44:279-83.
7. Konrad M, Mytilineos J, Ruder H, Opelz G, Scharer
K. HLA-DR7 predicts the response to alkylating agents
in steroid-sensitive nephrotic syndrome. Pediatr
Nephrol 1997;11:16-9.
8. Zhou GP, Guo YQ, Ji YH, Zhang GL Major histocompa-
sibility complex class II antigens in steroid-sensitive
nephrotic syndrome in Chinese children. Pediatr
Nephrol 1994;8:140-1.
9. Mir S, Kutukculer N, Kavakli K. Major histocompat-
ibility complex antigens in Turkish children with ste-
roid-responsive nephrotic syndrome. Pediatr Nephrol
1994;8:259-60.
10. Damanik MP, Hardyanto S, Gotoh A. Human leuco-
cyte antigens in primary nephrotic syndrome on Indo-
nesian children. KONAS V PERALMUNI, 24-26
Maret 2005, Yogyakarta.
11. Ruder H, Scharer K, Lenhard V, Wingen AM, Opelz
G. HLA phenotypes and idiopahtic nephrotic syn-
drome in children. Proc Eur Dial Transpl Assoc
1983;19: 602-6.
12. Zaki M, Daoud AS, Al Saleh QA, Al Najedi AK, White
AG. HLA antigens in Arab children with steroid–respon-
sive nephrotic syndrome. Pediatr Nephrol 1994;8:74-5.
13. Konrad M, Mytilineos J, Bouissou F, Scherer S, Gulli
MP, Meissner J, et al. HLA- class II association with
idiopathic nephrotic syndrome in children. Tissue an-
tigen 1994;43:275-80.
14. Al-Eisa AA, Haider M, Srivasta BS. HLA-DRB11 al-
leles in Kuwaiti children with idiopathic nephritic syn-
drome. Pediatr Nephrol 2000;15:79-81.
Published
2016-10-18
How to Cite
1.
Damanik M. HLA-B60 and HLA-DR4 alleles in Javanese children with steroid-sensitive primary nephrotic syndrome. PI [Internet]. 18Oct.2016 [cited 25Apr.2024];46(6):246-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/951
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Received 2016-10-17
Accepted 2016-10-17
Published 2016-10-18
Accepted 2016-10-17
Published 2016-10-18
