Morphology and disaccharidase activity of small intes- tinal mucosa in post-weaning-induced malnourished rats and after realimentation
Keywords:
small intestinal mucosa, disaccharidase activity, post-weaning-induced malnutrition, realimentation
Abstract
Background The most common cause of failure to thrive in in-fants is malnutrition which causes histological and biochemical
changes of small intestine. Studies on histology and enzyme ac-
tivity of small intestinal mucosa were not much developed.
Objective To study about histology and disaccharidases activity of
small intestinal mucosa in post-weaning-induced malnourished rats.
Methods We used Sprague-Dawley white rats as the subjects of
this study with post test-control group design. The study was per-
formed at the CentER for Research of Food and Nutrition Devel-
opment from April 2003 to December 2004.
Results There were a decrease of body weight (hypotrophy nor-
moblastic) and an increase of disaccharidase activity of small in-
testinal mucosa in post-weaning-induced malnourished rats. After
realimentation, there were an increase of body weight, an improve-
ment of the hypotrophy, and a decrease of the enzyme but they
still cannot reach normal condition.
Conclusion In malnourished rats, there are decrease of body
weight hypotrophy normoblastic and increase of disaccharidases
activity of intestinal mucosa that are improved after realimentation
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gestive organ development in suckling rats. Am J Clin
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cerna tikus putih: Perhatian khusus pada perkembangan
morfologis, biokimia, dan fisiologi terutama kolon
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Indonesia;1992.
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penggunaannya dalam praktek. Medan;1965.
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ridases. Analyt Biochem 1964;7:18-25.
13. Lebenthal E, Nitzan M, Chrzanowksi BL, Krantz B.
The effect of reduced maternofetal blood flow on the
development of fetal pancreatic acinar and enzymes.
Pediat Res1980;14:1356-9.
14. Shrader RE, Ferlatte MI, Zeman FJS. Early postnatal
development of the intestine in progeny of protein-
deprived rats. Bil Neonate 1977;31:181-98.
15. Firmansyah A, Suwandito L, Penn D, Lebenthal E. Pre
and postnatal nutrient depriviation causes hypotrophic
small intestinal and hypoplastic colonic mucosa. Am J
Clin Nutr 1988;47:779.
16. Hatch TF, Lebenthal E, Bransi D, Krasner. The effect
of early postnatal acquired malnutrition on intestinal
growth, disaccharidases and enterokinase. J Nutr
1979;109:1874-9.
17. Rossi TM, Lee PC, Young CM, Lerner A, Lebenthal E.
Effect of nutritional rehabilitation on the development
of intestinal brush-border disaccharidases of postna-
tally malnourished weanling rats. Int Pediatr Res
1983;20:793-7.
18. Butzner JD, Gall DG. Impact of refeeding on intestinal
development and function in infant rabbits subjected
to protein-energy malnutrition. Pediatr Res 1990;27:
245-51.
19. Jambunathan LR, Neuhoff D, Younoszai MK. Intesti-
nal disaccharidases in malnourished infant rats. Am J
Clin Nutr 1981;34:1879-84.
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Suharyono, penyunting. Esensial gastroenterologi anak.
Jakarta: Balai Penerbit FKUI; 1995. p. 97-107.
2. Behrman RE, Shiono PH. Neonatal risk factors. In:
Fanaroff AA, Martin RJ, editors. Neonatal-perinatal
medicine: Disease of the fetus and infant. 6th ed. St
Louis: Mosby; 1997. p. 3-12.
3. Prindull G, Manzar A. The ontogeny of the gut mu-
cosal immune system and the susceptibility to infec-
tion in infants of developing countries. Eur J Pediatr
1993;152:786-92.
4. Brundtland GH. Women of South East Asia: A health
profile. Regional publications SEARO No. 34; 2000.
5. Ahmed F. Novel foods across the lifespan, from infant
formula to impact on aging. Asia Pacific J Clin Nutr
2002;11(S6);S112-6.
6. Buchmiller-Crair TL, Gregg JP, River FA, Choi RS,
Diamond JM, Fonkalsrud EW. Delayed disaccharidase
development in a rabbit model of intrauterine growth
retardation. Pediat Res 2001;50:520-4.
7. Boersma B, Wit JM. Catch-up growth. Endocrin re-
views 1997;18:646-61. Available at: http://www.edrv.
endojournals.org/cgi/content/full/18/5/646.
8. Cook GC, Lee FD. The jejunum after kwashiorkhor.
Lancet 1966;1263-7.
9. Young CM, Lee PC, Lebenthal E. Maternal dietary re-
striction during pregnancy and lactation: Effect on di-
gestive organ development in suckling rats. Am J Clin
Nutr 1987;46:36-40.
10. Firmansyah A. Pengaruh malnutrisi terhadap saluran
cerna tikus putih: Perhatian khusus pada perkembangan
morfologis, biokimia, dan fisiologi terutama kolon
[disertasi]. Jakarta: Program Pascasarjana Universitas
Indonesia;1992.
11. Nainggolan M. Experiment design: Perencanaan dan
penggunaannya dalam praktek. Medan;1965.
12. Dahlqvist A. Method for assay of intestinal disaccha-
ridases. Analyt Biochem 1964;7:18-25.
13. Lebenthal E, Nitzan M, Chrzanowksi BL, Krantz B.
The effect of reduced maternofetal blood flow on the
development of fetal pancreatic acinar and enzymes.
Pediat Res1980;14:1356-9.
14. Shrader RE, Ferlatte MI, Zeman FJS. Early postnatal
development of the intestine in progeny of protein-
deprived rats. Bil Neonate 1977;31:181-98.
15. Firmansyah A, Suwandito L, Penn D, Lebenthal E. Pre
and postnatal nutrient depriviation causes hypotrophic
small intestinal and hypoplastic colonic mucosa. Am J
Clin Nutr 1988;47:779.
16. Hatch TF, Lebenthal E, Bransi D, Krasner. The effect
of early postnatal acquired malnutrition on intestinal
growth, disaccharidases and enterokinase. J Nutr
1979;109:1874-9.
17. Rossi TM, Lee PC, Young CM, Lerner A, Lebenthal E.
Effect of nutritional rehabilitation on the development
of intestinal brush-border disaccharidases of postna-
tally malnourished weanling rats. Int Pediatr Res
1983;20:793-7.
18. Butzner JD, Gall DG. Impact of refeeding on intestinal
development and function in infant rabbits subjected
to protein-energy malnutrition. Pediatr Res 1990;27:
245-51.
19. Jambunathan LR, Neuhoff D, Younoszai MK. Intesti-
nal disaccharidases in malnourished infant rats. Am J
Clin Nutr 1981;34:1879-84.
Published
2016-10-18
How to Cite
1.
Sosrosumihardjo R, Firmansyah A, Rasad A, Harjodisastro D, Ridwan E, Wanandi S, Retno D. Morphology and disaccharidase activity of small intes- tinal mucosa in post-weaning-induced malnourished rats and after realimentation. PI [Internet]. 18Oct.2016 [cited 23Dec.2024];46(5):229-5. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/935
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Received 2016-10-16
Accepted 2016-10-16
Published 2016-10-18
Accepted 2016-10-16
Published 2016-10-18
