Morphology and disaccharidase activity of small intes- tinal mucosa in post-weaning-induced malnourished rats and after realimentation

Main Article Content

Rustadi Sosrosumihardjo
Agus Firmansyah
Asri Rasad
Daldiyono Harjodisastro
Endi Ridwan
Septilia Inawati Wanandi
Dwirini Retno

Abstract

Background The most common cause of failure to thrive in in-
fants is malnutrition which causes histological and biochemical
changes of small intestine. Studies on histology and enzyme ac-
tivity of small intestinal mucosa were not much developed.
Objective To study about histology and disaccharidases activity of
small intestinal mucosa in post-weaning-induced malnourished rats.
Methods We used Sprague-Dawley white rats as the subjects of
this study with post test-control group design. The study was per-
formed at the CentER for Research of Food and Nutrition Devel-
opment from April 2003 to December 2004.
Results There were a decrease of body weight (hypotrophy nor-
moblastic) and an increase of disaccharidase activity of small in-
testinal mucosa in post-weaning-induced malnourished rats. After
realimentation, there were an increase of body weight, an improve-
ment of the hypotrophy, and a decrease of the enzyme but they
still cannot reach normal condition.
Conclusion In malnourished rats, there are decrease of body
weight hypotrophy normoblastic and increase of disaccharidases
activity of intestinal mucosa that are improved after realimentation

Article Details

How to Cite
1.
Sosrosumihardjo R, Firmansyah A, Rasad A, Harjodisastro D, Ridwan E, Wanandi S, Retno D. Morphology and disaccharidase activity of small intes- tinal mucosa in post-weaning-induced malnourished rats and after realimentation. PI [Internet]. 18Oct.2016 [cited 25Jul.2021];46(5):229-5. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/935
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Articles
Author Biographies

Rustadi Sosrosumihardjo

Department of Clinical Pathology, Medical School, University of Indonesia, Jakarta, Indonesia

Agus Firmansyah

Department of Child Health, Medical School, University of Indonesia, Jakarta, Indonesia

Asri Rasad

Department of Biochemistry and Biomoleculer, Medical School, University of Indonesia, Jakarta, Indonesia

Daldiyono Harjodisastro

Department of Internal Medicine, Medical School, University of Indonesia, Jakarta, Indonesia

Endi Ridwan

Center for Research and Development of Food Nutrition, Bogor, Indonesia.

Septilia Inawati Wanandi

Department of Biochemistry and Biomoleculer, Medical School, University of Indonesia, Jakarta, Indonesia

Dwirini Retno

Department of Biochemistry and Biomoleculer, Medical School, University of Indonesia, Jakarta, Indonesia
Received 2016-10-16
Accepted 2016-10-16
Published 2016-10-18

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