Relationships between plasma zinc and ferritin with nutritional status in thalassemic children
Keywords:
zinc, ferritin, nutritional status, thalassemia
Abstract
Background Repeated blood transfusions in thalassemic chil-dren can lead to iron overload in the body. High ferritin level leads
to low plasma zinc status because of their competitive inhibition.
Previous study found that there was a correlation between plasma
zinc level and nutritional status.
Objective To obtain plasma zinc level, to investigate the correla-
tion between plasma zinc and ferritin, and the impact of plasma
zinc on nutritional status in children with thallasemia.
Methods A cross sectional study was conducted on 67 thalas-
semic children. This study was performed at Thalassemia Center,
Cipto Mangunkusumo Hospital, Jakarta, from 1 st until 31 st of March
2005. The age of the patients ranged from 4 to 18 years, with fer-
ritin levels more than 2000 ng/ml during the last 6 months or total
transfusion more than 5 liters. The subjects were divided into 2
groups, i.e. group 1 (4-10 years) and group 2 (>10-18 years). Di-
etary intake was assessed by 3 day-dietary recall. The nutritional
status were judged by mid upper arm circumference (MUAC) for
age and height for age (H/A). Venous blood was obtained to mea-
sure plasma zinc and ferritin levels. Statistical analysis was done
by Student’s t-test (2-tailed) and linear regression analysis.
Results We found that 42% subjects were well-nourished, 51%
were undernourished, and 7% were severely malnourished. All sub-
jects had low plasma zinc status 31.9 (SD 16.9) μg/dl. There was a
weak negative correlation between plasma zinc and ferritin level (r
= -0.282, P=0.021). Lower zinc intake was detected in 65 out of 67
subjects.
Conclusion All thalassemic children in our hospital had low plasma
zinc level. There was a weak negative correlation between plasma
zinc level and ferritin level. There was no significant correlation
between plasma zinc status and nutritional status
References
1. Wahidiyat I. Penelitian thalassemia di Jakarta [thesis].
Jakarta: Intermega; 1979.
2. Wahidiyat I. Historical perspective of thalassaemia
management in Indonesia. Naskah lengkap simposium
new horizon in thalassaemia control. Presented in
Jakarta, June 11-12, 2002.
3. Nasar SS. Peran mikronutrien dan prebiotik pada
kekebalan tubuh. Naskah lengkap simposium peranan
prebiotik pada kekebalan tubuh. Presented in Jakarta
June 28, 2004.
4. Almatsier S. Mineral mikro. In: Prinsip dasar ilmu gizi.
1st edition. Jakarta: PT. Gramedia Pustaka Utama;
2001. p. 249-57.
5. Boccio J, Bioch JS, Zubillaga M, Pharm LA, Caro R,
Antoine J. Iron and zinc interactions evaluated be-
tween different mineral sources in different nutri-
tional matrixes. Food and nutrition bull 2002;23:
195-8.
6. Brown KH, Wuehler SE, Peerson JM. The importance
of zinc in human nutrition and estimation of the glo-
bal prevalence of zinc deficiency. Food and nutrition
bull 2001;22:113-22.
7. Hambidge M. Human zinc deficiency. The journal of
nutrition 2000;130:1344S-9S.
8. King JC, Keen CL. Zinc. In: Modern nutrition in health
and disease. 9th edition. Philadelphia: Lippincott
Williams&Wilkins; 1998. p. 223-37.
9. Hunt JR. Bioavailability of iron, zinc, and other trace
minerals from vegetarian diets. Am J Clin Nutr
2003;78:633S-9S.
10. Tanphaichitr VS, Visuthi B. Causes of inadequate pro-
tein-energy status in thalassemic children. Asia Pacific
J Clin Nutr 1995;133-5.
11. Zinc deficiency in thalassemia. Available from URL:
http://raredisease.info.nih.gov/html/ nutrientmetabolism
05241999.html. (Cited January 10, 2004).
12. Dijkhuizen MA, Wieringa FT, West CE, Martuti S,
Muhilal. Effect of iron and zinc supplemetation in
Indonesian infants on micronutrient status and
growth. Am Society for nutritional sciences
2001;2860-5.
13. Sekartini R, Soedjatmiko, Gunardi H, Pakasi T. Status
kadar seng dan besi pada anak usia sekolah dasar di
Jakarta [research]. Jakarta; 2003.
14. Wulandari HF. Gambaran radiologis tulang penderita
thalassemia beta dan thalassemia beta haemoglobin E
saat diagnosis [thesis]. Jakarta; 1999.
15. Purnama Dewi L. Profil pertumbuhan jasmani pada
pasien thalassemia mayor [thesis]. Jakarta; 1993.
Jakarta: Intermega; 1979.
2. Wahidiyat I. Historical perspective of thalassaemia
management in Indonesia. Naskah lengkap simposium
new horizon in thalassaemia control. Presented in
Jakarta, June 11-12, 2002.
3. Nasar SS. Peran mikronutrien dan prebiotik pada
kekebalan tubuh. Naskah lengkap simposium peranan
prebiotik pada kekebalan tubuh. Presented in Jakarta
June 28, 2004.
4. Almatsier S. Mineral mikro. In: Prinsip dasar ilmu gizi.
1st edition. Jakarta: PT. Gramedia Pustaka Utama;
2001. p. 249-57.
5. Boccio J, Bioch JS, Zubillaga M, Pharm LA, Caro R,
Antoine J. Iron and zinc interactions evaluated be-
tween different mineral sources in different nutri-
tional matrixes. Food and nutrition bull 2002;23:
195-8.
6. Brown KH, Wuehler SE, Peerson JM. The importance
of zinc in human nutrition and estimation of the glo-
bal prevalence of zinc deficiency. Food and nutrition
bull 2001;22:113-22.
7. Hambidge M. Human zinc deficiency. The journal of
nutrition 2000;130:1344S-9S.
8. King JC, Keen CL. Zinc. In: Modern nutrition in health
and disease. 9th edition. Philadelphia: Lippincott
Williams&Wilkins; 1998. p. 223-37.
9. Hunt JR. Bioavailability of iron, zinc, and other trace
minerals from vegetarian diets. Am J Clin Nutr
2003;78:633S-9S.
10. Tanphaichitr VS, Visuthi B. Causes of inadequate pro-
tein-energy status in thalassemic children. Asia Pacific
J Clin Nutr 1995;133-5.
11. Zinc deficiency in thalassemia. Available from URL:
http://raredisease.info.nih.gov/html/ nutrientmetabolism
05241999.html. (Cited January 10, 2004).
12. Dijkhuizen MA, Wieringa FT, West CE, Martuti S,
Muhilal. Effect of iron and zinc supplemetation in
Indonesian infants on micronutrient status and
growth. Am Society for nutritional sciences
2001;2860-5.
13. Sekartini R, Soedjatmiko, Gunardi H, Pakasi T. Status
kadar seng dan besi pada anak usia sekolah dasar di
Jakarta [research]. Jakarta; 2003.
14. Wulandari HF. Gambaran radiologis tulang penderita
thalassemia beta dan thalassemia beta haemoglobin E
saat diagnosis [thesis]. Jakarta; 1999.
15. Purnama Dewi L. Profil pertumbuhan jasmani pada
pasien thalassemia mayor [thesis]. Jakarta; 1993.
Published
2016-10-18
How to Cite
1.
Arijanty L, Nasar S, Madiyono B, Gatot D. Relationships between plasma zinc and ferritin with nutritional status in thalassemic children. PI [Internet]. 18Oct.2016 [cited 22Nov.2024];46(5):220-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/933
Section
Articles
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Received 2016-10-16
Accepted 2016-10-16
Published 2016-10-18
Accepted 2016-10-16
Published 2016-10-18
