Left ventricular functions and mass of the adolescents and young adults with thalassemia major: An echocardiography study

  • Muhammad Ali
  • Sukman Tulus Putra
  • Djajadiman Gatot
  • Sudigdo Sastroasmoro
Keywords: thalassemia major, left ventricular functions and mass, ferritin serum concentration

Abstract

Background Thalassemia major (TM) is a transfusion-depen-
dent disease. Multiple transfusions cause an accumulation of iron
in the body. On the heart, iron can induce cardiomyopathy, the
leading cause of death in TM.
Objective To evaluate left ventricular functions and mass among
adolescents and young adults with TM.
Methods A cross-sectional study was conducted on 58 patients
with TM in Cipto Mangunkusumo Hospital, Jakarta. Hematological
data was collected from medical record. Left ventricular systolic func-
tions (EF, FS), diastolic functions (A, E, E/A ratio, IVRT), and mass
(LVDDi, LVDSi, LVMi) were detected using an echocardiography
Sonos 4500. T test, linier regression, and multiple regression analy-
sis were performed.
Results Out of 32 TM patients, 30 were enrolled to study. Left
ventricular systolic and diastolic functions of TM patients were lower
than those of the control and statistically significant [EF 66.1% (SD
4.9) and 71.6% (SD 5.6); P<0.0001, FS 36.0% (SD 3.7) and 39.8%
(SD 5.5); P=0.003, E/A 2.14 (SD 0.4) and 1.83 (SD 0.3); P=0.002,
respectively]. Left ventricular mass of TM patients was greater than
that of control, and also statistically significant [LVMi 111.1 g/m 2
(SD 30.8) and 75.4 g/m 2 (SD 14.5); P<0.0001, respectively]. Linier
and multiple regression analysis showed significant and powerful
correlation between left ventricular diastolic functions (E/A ratio)
and serum ferritin concentration (r=0.71; P<0.0001).
Conclusion Left ventricular functions and mass of adolescents
and young adults with TM show abnormalities. The higher the con-
centration of ferritin serum is, the more likely for TM patient to suf-
fer from diastolic abnormality

Author Biographies

Muhammad Ali
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.
Sukman Tulus Putra
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.
Djajadiman Gatot
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.
Sudigdo Sastroasmoro
Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

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Published
2016-10-18
How to Cite
1.
Ali M, Putra S, Gatot D, Sastroasmoro S. Left ventricular functions and mass of the adolescents and young adults with thalassemia major: An echocardiography study. PI [Internet]. 18Oct.2016 [cited 28Mar.2024];46(5):214-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/932
Received 2016-10-16
Accepted 2016-10-16
Published 2016-10-18