Predictors for the recurrent febrile seizures after the first complex febrile seizures

Main Article Content

Conny Tanjung
Irawan Mangunatmadja
Sudigdo Sastroasmoro
I. Budiman


Background Complex febrile seizures (CFS) have been shown
to be related to recurrence and epilepsy. Many studies were done
to determine the predictors of recurrence in both simple and com-
plex febrile seizures. To our knowledge until now there is no pub-
lished data that specially looks for predictors of recurrence after a
first CFS.
Objective To find out clinical and demographical characteristics
of a first CFS and to define the predictors for the recurrent febrile
Methods Prospective survival analysis study was done in chil-
dren with first CFS who visited Cipto Mangunkusumo Hospital,
Jakarta, over 14 months periods. The predictors for development
of recurrence were analyzed by SPSS for Windows 11.5 using
Kaplan-Meier test and Cox regression model with a level of signifi-
cance <0.05.
Results There were 62 subjects completed this study. Male-to-
female ratio was 1.4:1. The mean age at onset was 18.2 months.
Recurrence occurred in 9 subjects (14.5%). Body temperature
between 38-38.5°C (7 of 26 subjects, P=0.02), upper motor neu-
ron type of delayed development (3 of 7 subjects, P=0.03), and
epileptic history in the family (2 of 2 subjects, P<0.05) were asso-
ciated with recurrence in bivariate analysis. In multivariate analy-
sis only body temperature between 38-38.5°C (HR 1.6, 95% CI
1.0;23.9) and epileptic history in the family (HR 16.9, 95% CI
2.8;101.4) were identified as predictors.
Conclusion Low body temperature at the first seizures and epi-
leptic history in the family were independent predictors for the re-
currence after a first CFS

Article Details

How to Cite
Tanjung C, Mangunatmadja I, Sastroasmoro S, Budiman I. Predictors for the recurrent febrile seizures after the first complex febrile seizures. PI [Internet]. 18Oct.2016 [cited 18Oct.2019];46(5):204-. Available from:
Author Biographies

Conny Tanjung

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

Irawan Mangunatmadja

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

Sudigdo Sastroasmoro

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.

I. Budiman

Department of Child Health, Medical School, University of
Indonesia, Jakarta, Indonesia.
Received 2016-10-16
Accepted 2016-10-16
Published 2016-10-18


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