Relation of bleeding patterns and factor VIII levels in children with hemophilia
Keywords:
hemophilia A, bleeding patterns, hemophilia classification
Abstract
Background The high costs of factor VIII examination cause thedelay in the diagnosis of hemophilia A; consequently many pa-
tients do not receive adequate therapy which results in failure to
survive into adulthood or survive with creeple.
Objective To determine bleeding patterns of hemophilia A pa-
tients for the prediction of its classification.
Methods We perform retrospective analysis of hemophilia patients
at the Integrated Service Center of Hemophilia, Cipto Mangun-
kusumo Hospital, Jakarta.
Results Family history, age at the first bleeding, frequency of bleed-
ing, and factor VIII examination can significantly differentiate the
classification of hemophilia A (P=0.015; 0.014; <0.0001; and
<0.0001, respectively) while age groups, triggering trauma for the
first bleeding, type of the first bleeding, history of previous trauma,
the most frequent type of bleeding, age at diagnosis, and con-
sumption of cryoprecipitate cannot. (P=0.985; 0.475; 0.342; 0.318;
0.058; 0.477; and 0.547, respectively).
Conclusion Age at first bleeding, frequency of bleeding, and fam-
ily history can be used to predict classification of hemophilia A.
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fluid phase. In: Nathan DG, Oski FA, editors. Hema-
tology of infancy and childhood. 4th ed. Philadelphia:
Saunders; 1993. p. 1605-50.
2. Corrigan JJ. Hemorrhagic disorder. In: Berhman RE,
Kleigman RM, Nelson WE, Vaughan III VC, editors.
Nelson textbook of pediatrics. 15th ed. Philadelphia:
Saunders; 1996. p. 1424-7.
3. Srivastava A. Delivery of hemophilia care in the de-
veloping world. Hemophilia 1998;4:33-40.
4. Isarangkura P. Hemophilia care in the developing
world: Benchmarking for excellence. Hemophilia
2002;8:205-10.
5. Ljung R, Vournas AS, Auberger KK. Treatment of chil-
dren with hemophilia in Europe: A survey of 20 cen-
tres in 16 countries. Hemophilia 2000;6:619-24.
6. Nillson IM. Hemophilia. Malmo: Pharmacia plasma
product;1994. p. 2-98.
7. Carvell JE, Duthie RB. Management of the hemo-
philic knee. In: Insall JN, editor. Surgery of the knee.
1st ed. New York: Churchill Livingstone;1998. p.
741-74.
8. Lusher JM, Warrier I. Hemophilia A. Hematol Oncol
Clin North Am 1992;6:1021-33.
9. Dimichele D, Neufeld EJ. Hemophilia: A new approach
to an old disease. Hematol Oncol Clin North Am
1998;12:1315-44.
10. On Wuzurike N, Warrier I, Lusher M. Types of bleed-
ing seen during the first 30 month of life with se-
vere hemophilia A and B. Hemophilia 1996;2:137-
40.
11. Jones P. Guideline for the development of national
programme for hemophilia. Newcastle: World Federa-
tions of hemophilia; 1996. p. 1-48.
12. Corrigan JJ. Coagulation disorders. In: Miller DR,
Baechner RL, editors. Blood disease of infancy and
childhood. 6th ed. Saint Louis: CV Mosby Company;
1990. p. 47-65.
13. Hillgartner MW, Mc Milan CW. Coagulation disor-
der. In: Miller DR, Pearson HA, Bachner RL, edi-
tors. Smith’s blood diseases of infancy and childhood.
4th ed. Saint Louis; 1978. p. 771-90.
Published
2016-10-18
How to Cite
1.
Rahardiani R, MZ HS, Firmansyah A. Relation of bleeding patterns and factor VIII levels in children with hemophilia. PI [Internet]. 18Oct.2016 [cited 22Nov.2024];46(4):159-3. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/921
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Received 2016-10-14
Accepted 2016-10-14
Published 2016-10-18
Accepted 2016-10-14
Published 2016-10-18
