Main Article Content
Background Iron deficiency anemia (IDA) is frequently
found in school-aged children. The main treatments for IDA
are overcoming the causal factors and iron supplementation.
Noncompliance in taking iron tablets and the possibility of iron
absorbtion or transport difficulties, can reduce efficacy of daily oral
iron supplementation. Because excess iron storage in the intestinal
cells can lead to mucosal blockage, twice weekly oral iron therapy
may be considered instead of daily dosage.
Objective To compare the effects of daily vs. twice weekly ferric
sodium edetate (NaFeEDTA) on hemoglobin (Hb), hematocrit
(Ht), mean corpuscular volume (MCV), mean corpuscular
hemoglobin (MCH), and mean corpuscular hemoglobin
concentration (MCHC) levels on children with IDA.
MethodsWe conducted an open-label, randomized, prospective
study in 36 children with IDA aged 5-11 years. Subjects were
divided into two groups. For a one-month period, group I received
daily iron therapy (NaFeEDTA) and group II received twice
weekly iron therapy. Examinations of Hb, Ht, MCV, MCH, MCHC
were performed before and after iron therapy.
Results There were no significant differences in Hb, Ht, MCV,
MCH or MCHC levels after therapy between the daily and twice
weekly NaFeEDTA groups (P > 0.05).
Conclusion Twice weekly NaFeEDTA therapy is as effective as
daily NaFeEDTA administration in children with IDA.
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