Probiotic treatment in children with lactose intolerance – An open labeled the one group pre-test post-test experimental study
Keywords:
lactose intolerance, probiotic (Lactobacillus acidophilus, Bifidobacterium longum, and Streptococcus faecium), breath-hydrogen test (BHT)
Abstract
Background Lactose intolerance is the most common disorder ofintestinal carbohydrate digestion. Probiotic that contains the cor-
rect strain in appropriate amount can be used as an alternative
dietary for lactose intolerance patients.
Objective This study was designed to describe the role of probiotic
in relieving lactose intolerance symptoms in children consumed
full-cream milk.
Methods This study was a clinical trial. Inclusion criteria was chil-
dren aged 12-14 years old, had a good nutrition and health status,
with positive breath hydrogen test (BHT) result and lactose intoler-
ance symptom(s), and their parents gave consent. Forty-two chil-
dren were included. All subjects consumed one glass (200 ml) of
full-cream milk twice a day for 21 days and recorded intolerance
symptoms. Probiotic was added from 8 th to 21 st day in their milk,
and responses of treatment were evaluated by scoring system
(based on borborigmic, flatulence, abdominal bloating, nausea and
vomiting, abdominal pain, and diarrhea symptoms). At the end of
study they were undergone second BHT examination.
Results There were decreasing mean score rates at 7 th day (pre)
13.8 (SD 5.5) compared with 7.5 (SD 3.5) at 14 th day (after) and
was statistically significant (P<0.001). Mean score rate at 7 th day
(pre) 13.8 (SD 5.5) compared with 21 st day (after) was 0.119 (SD
0.55) and was statistically significant (P<0.001). At the end of study,
only 2 subjects showed clinical signs of lactose intolerance. Thirty-
six subjects had normal BHT result at 21 st day and was statisti-
cally significant (P<0.001).
Conclusion Two weeks administration of probiotic could relieve
lactose intolerance symptoms in children consumed full-cream milk
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Nutr 1988;47:57-60.
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Med 1991;89:175-84.
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Pediatr Health Care 2003;17:277-283.
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Ch, Schrezenmeir J. Probiotic–compensation for lactase
insufficiency. Am J Clin Nutr 2001;73(suppl): 421s-9s.
18. Briet F, Pochart P, Marteau P, Flourie B, Arrigani B,
Ramband JC. Improved clinical tolerance to chronic
lactose ingestion in subjects with lactose intolerance:
a placebo effect? Gut 1997;41:632-5.
19. Martini MC, Lerebours EC, Jin Lin W, Harlander SK,
Berroda NM, Antoine JM, et al. Strains and species of
lactic acid bacteria in fermented milks (yoghurts):
Effect on in vivo lactose digestion. Am J Clin Nutr
1991;54:1041-6.
20. Savaiano DA, Smith DE, Martini MC. Lactose diges-
tion from flavored and frozen yoghurts, milk, and ice
cream by lactase-deficient persons. Am J Clin Nutr
1987;46:636-40.
21. Shermak MA, Saavedra JM, Jackson TL, Huang SS,
Bayless TM, Perman JA. Effect of yoghurt on symptoms
and kinetics of hydrogen production in lactose-
malabsorbing children. Am J Clin Nutr 1995; 62:1003-6.
dengan makanan bayi. Sari Pediatri 1994;1:17-20.
2. Sunoto. Intoleransi laktosa. Bahan Kuliah Bagian Ilmu
Kesehatan Anak FKUI-RSCM, Jakarta, 1991. p.1-6.
3. Zhong V, Priebe MG, Vonk RJ, Huang CY, Antonie
JM, Harmsen HJ, et al. The role of colonic
microbiota in lactose intolerance. Dig Dis Sci
2004;49:78-83.
4. Firmansyah A. Laktosa dan laktase, aspek biokimiawi
dan laboratorium. Bahan Kuliah Bagian Ilmu Kesehatan
Anak FKUI RSCM, Jakarta. p.1-10.
5. Buller HA. Lactase phlorizin hydrolase: A review of
the literature [dissertation]. Netherland: University of
Amsterdam; 1990. p.2-25.
6. Schmitz J. Malabsorption. In: Walker WA, Durie PR,
Hamilton JR, editors. Pediatric gastrointestinal disease.
St-Louis: Mosby, 1996. p.83-95.
7. Levine B. About lactose intolerance. Nutr Tod
1996;31:78-9.
8. Gilliland SE, Kim HS. Effect of viable starter culture
bacteria in yoghurt on lactose utilization in humans. J
Dairy Sci 1984;67:1-6.
9. More about lactose intoleransce (editorial), [cited
September 7, 2002] Available from: URL: http://www.-
geocities.com.
10. Fuller R. Probiotic in human medicine. Gut 1991;
32:439-42.
11. Reid G. Regulatory and clinical aspect of dairy
probiotic. FAO/WHO expert consultation on evalua-
tion of health and nutritional properties of powder milk
with live lactic bacteria, 2001.
12. Ahmad R. Probiotik: Aspek kesehatan, keamanan,
dan regulasi, SEAMEO-TROPMED Regional Center
for Community Nutrition, Universitas Indonesia. Pre-
sented at Malam Klinik IDAI, 2002.
13. Martini MC, Savaiano DA. Reduced intolerance symp-
toms from lactose consumed during a meal. Am J Clin
Nutr 1988;47:57-60.
14. Montes RG, Perman JA. Lactose intolerance. Postgrad
Med 1991;89:175-84.
15. Young RJ, Huffman S. Probiotic use in children. J
Pediatr Health Care 2003;17:277-283.
16. Kerzner B. Breath tests. In: Wyllie R, Hyams JS, edi-
tors. Pediatric gastrointestinal disease patophysiology,
diagnosis, management. 9th ed. Philadephia: WB
Saunders, 1993. p.1027-37.
17. Vrese MD, Stegelmann A, Richter B, Frenselan S, Laue
Ch, Schrezenmeir J. Probiotic–compensation for lactase
insufficiency. Am J Clin Nutr 2001;73(suppl): 421s-9s.
18. Briet F, Pochart P, Marteau P, Flourie B, Arrigani B,
Ramband JC. Improved clinical tolerance to chronic
lactose ingestion in subjects with lactose intolerance:
a placebo effect? Gut 1997;41:632-5.
19. Martini MC, Lerebours EC, Jin Lin W, Harlander SK,
Berroda NM, Antoine JM, et al. Strains and species of
lactic acid bacteria in fermented milks (yoghurts):
Effect on in vivo lactose digestion. Am J Clin Nutr
1991;54:1041-6.
20. Savaiano DA, Smith DE, Martini MC. Lactose diges-
tion from flavored and frozen yoghurts, milk, and ice
cream by lactase-deficient persons. Am J Clin Nutr
1987;46:636-40.
21. Shermak MA, Saavedra JM, Jackson TL, Huang SS,
Bayless TM, Perman JA. Effect of yoghurt on symptoms
and kinetics of hydrogen production in lactose-
malabsorbing children. Am J Clin Nutr 1995; 62:1003-6.
Published
2016-10-18
How to Cite
1.
Arifin Z, Boediarso A, Tambunan T. Probiotic treatment in children with lactose intolerance – An open labeled the one group pre-test post-test experimental study. PI [Internet]. 18Oct.2016 [cited 22Nov.2024];46(3):139-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/917
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Received 2016-10-14
Accepted 2016-10-14
Published 2016-10-18
Accepted 2016-10-14
Published 2016-10-18
