Quantitative NS1 antigen and the severity of dengue virus infections
Abstract
Background Dengue infection is one of the main cause of
morbidity and mortality in children in Indonesia. Since it is known
that earlier treatment and supportive therapies can decreased case
fatality rate from dengue hemorrhagic fever (DHF), identification
of children who have risks to develop to DHF must be quickly
identified, mainly in areas of endemic.
Objective To find a correlation between increased quantitative
secreted nonstructural protein-1 (sNS1) with clinical course of
severe dengue infections.
Methods This was a cross-sectional study conducted on children
with dengue infections in Tropical Infections Division of Child
Health Department, Sanglah Hospital, Denpasar. Detection of
the dengue antigen was made by examining sNS1 quantitative
immuno-assay. Analysis correlation of Spearman test was used to
look the relationship between increased quantitative sNS1 with
clinical course of severe dengue infections.
Results There was a positive relationship between quantitative
sNS1 and clinical course of severe dengue infections with a value
of r = 0.903, P=0.001. Increased sNS1 level had a positive
correlation with more severe dengue infections.
Conclusions Quantitative sNS1 titer has a strong positive
correlation with clinical course of severe dengue infections.
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Accepted 2016-06-29
Published 2015-04-30
