Randomized controlled trial of Phyllanthus niruri Linn extract
AbstractBackground Clinical benefits of antiviral treatment in children
experience varicella without complications, remains controversial.
Phyllanthus niruri Linn extract as a natural medicine is used to
increase cellular and humoral immunity.
Objective To determine the efficacy and safety of Phyllanthus
niruri Linn extract in the treatment of varicella in children compared
Methods This was a double-blind randomized controlled trial on
children ages 2-14 years who experienced varicella without com-
plications. Subjects were randomly assigned to receive either
Phyllanthus niruri Linn extract syrup (5 mg/5ml, 3 times daily) or
placebo. Efficacy was measured by calculating the number of pap-
ules and crusts after taking the extract for 4 days of administration.
A five-day monitoring sheet to record daily follow up and adverse
effects of the subjects were given to their parents.
Results Efficacy of Phyllanthus niruri Linn measurement based
on no more new papules occurred at the five-day monitor was de-
tected in 46 subject (51.1%) of the Phyllantus niruri Linn group
compared to the placebo group (P=0.723). Meanwhile, the differ-
ence of efficacy based on time of crusts disappear in Phyllanthus
niruri Linn and placebo group were 22 subjects (43.1%) and 15
subject (30.0%), respectively (P=0.053). This finding proved have
clinical benefit (NNT=7.6).
Conclusion There was no significant difference between the ef-
ficacy of Phyllanthus niruri Linn and placebo in terms of the pre-
vention appearing new papules and crusts. However, clinically
Phyllanthus niruri Linn accelerates appearing and aborting crust
compared to placebo
tent/asset/adam_disease_varicella. Cited October 12th
2. Syoeaib AA. Varisela. In: Soedarmo SP, Garna H,
Hadinegoro SR, editors. Buku Ajar Ilmu Kesehatan
Anak Infeksi dan Penyakit Tropis. 1st ed. Jakarta: Balai
Penerbit FKUI; 2002. p. 152-9.
3. Committee on Infectious Disease. The use of oral
acyclovir in otherwise healthy children with varicella.
4. Kelompok Studi Herpes Indonesia. Infeksi herpes,
pedoman pengobatan asiklovir untuk dokter. Jakarta,
Oktober 1995. p. 6-7.
5. Djauzi S. Manfaat imunostimulan pada penyem-
buhan infeksi. Presented in Simposium Update Al-
lergy and Clinical Immunology. Bogor, 10-11
6. Maat S. Phyllanthus niruri L sebagai imunostimulator
pada mencit. Disertasi Program Pasca Sarjana, Uni-
versitas Airlangga, Surabaya. 1997.
7. Direktorat Pengawasan Obat dan Makanan, DepKes
RI. Pedoman pelaksanaan uji klinik obat tradisional.
Jakarta. 2000. p. 8-9.
8. Ooi PL, Goh KT, Dorasingham S, Ling AE. Prevalence
of varicella-zoster virus infection in Singapore. South-
east Asean J Trop Med Pub Health 1992;23:22-5.
9. Kurniati SC. Pengobatan oral infeksi varisela-zoster
dengan kombinasi ekstrak phyllanti herba dan terapi
standar dibandingkan dengan terapi standar tunggal.
Clinical Research Division of Dexa Medica Pharmaceu-
tical. Jakarta; 2002.
10. Gershon A, Russa P. Varicella-zoster infections. In:
Krugman S, Katz SL, Gershon A, editors. Infectious
Diseases of Children. 9th ed. St Louis: Mosby; 1992.
11. Munasir Z. The role of phyllanti herba in the treatment
of upper respiratory tract infections in paediatric pa-
tients. Clinical Research Division of Dexa Medica
Pharmaceutical. Jakarta; 2002.
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