Relationship between serum cystatin-C and urinary neutrophil gelatinase-associated lipocalin in septic children
Abstract
Background Sepsis may lead to acute kidney injury (AKI)
in patients treated in pediatric intensive care units (PICU).
Currently, serum creatinine is used as a biomarker for the
diagnosis of AKI. However, it is not a sensitive nor specific
test for AKI. The scarcity of biomarkers leads to delays in the
diagnosis and treatment of AKI. Serum cystatin-C (sCys-C)
and urinary neutrophil gelatinase-associated lipocalin (uNGAL)
are potential biomarkers that look promising for early diagnosis
of AKI.
Objective To identify the relation of cystatin-C and NGAL in
children with sepsis.
Methods Serum cystatin-C and uNGAL were measured on
septic patients aged one month to 12 years. The diagnoses
of sepsis were based on the 2002 International Pediatric Sepsis
Concensus. Patients were admitted to the Pediatric Intensive
Department of the Prof. Dr. R. D. Kandou Hospital, Manado
from January to June 2013. The exclusion criteria were
patients with trauma, burns, severe dehydration, malnutrition,
obesity, and history of renal diseases. Data analyses included
descriptions for the characteristic data and Pearson’s coefficient
correlation. A P value of 0.05 was considered to be statistically
significant. Data were analyzed with SPSS software for Windows
version 21.
Results Thirty-eight patients met the inclusion criteria, of whom
23 were male and 15 were female. Their mean age was 22.6 (SD
32.24) months, with overweight in 2 children, good nutrition in
25 children, and under nutrition in 11 children. An increased
level of sCys-C was found in 22 children and an increased level
of uNGAL was found in 19 children. Serum cystatin-C was
significantly correlated to uNGAL in septic patients (r=0.614;
P<0.01).
Conclusion There is a positively correlated relationship between
sCys C and uNGAL in septic children. Increased sCys C is associated with increased uNGAL in septic children.
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Accepted 2016-06-29
Published 2015-04-30
