Correlation between obesity with atopy and family history of atopy in children

Putria Rayani Apandi; Budi Setiabudiawan; Abdurachman Sukadi

doi:10.14238/pi51.4.2011.227-33

Putria Rayani Apandi Department of Child Health, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin Hospital, Bandung, West Java
Budi Setiabudiawan Department of Child Health, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin Hospital, Bandung, West Java
Abdurachman Sukadi Department of Child Health, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin Hospital, Bandung, West Java

DOI: https://doi.org/10.14238/pi51.4.2011.227-33

Keywords: atopy, family history of atopic disease, obesity

Abstract

Background The prevalence of childhood obesity and atopy has increased in recent decades. Research on links between obesity and atopy has shown varied results. Few previous studies have reported on the significance of family history of atopic disease in children.

Objective To determine correlation between obesity with atopy and family history of atopic disease in children.

Methods This cross-sectional study was conducted from April to September 2010 in the Pediatric Allergy-Immunology subdivision, Hasan Sadikin Hospital. Children aged 6âˆ’11 years were divided into four groups of 40 each: obese subjects with and without family history of atopic disease, and normal weight subjects with and without family history of atopic disease. Skin prick test was performed to determine which subjects had atopy. Chi-square test was used to analyze mutual independence, and partial Chi-square test was used to analyze correlation of obesity to atopy and family history of atopic disease in children. Environmental factors, type of childbirth, and pregnancy history were also analyzed as risk factors for atopy.

Results Of 80 obese children with and without family history of atopic disease, 40 (100%) and 38 (95%), respectively, were atopic. Of 80 normal weight children with and without family history of atopic disease, 39 (98%) and 9 (23%), respectively, were atopic. Thus atopy was observed in 126 subjects, while the remaining 34 subjects were non-atopic. Partial test showed a correlation between obesity with atopy and family history of atopic disease (P < 0.001). There were no significant differences in risk factors for atopy by group.

Conclusion Obesity correlates with atopy and family history of atopic disease in children.

References

1. Schneider MBMB, Brill SR. Obesity in children and adolescents. Pediatr Rev. 2005;26:155-62.
2. WHO. Obesity: preventing and managing the global epidemic. Geneva: WHO Technical Report Series; 2000.
3. Dixit VD. Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanism regulating immunity and health span. J Leuco Biol. 2008;84:1-11.
4. Wahn U, Mutius EV. Childhood risk factors for atopy and the importance of early intervention. J Allergy Clin Immunol. 2001;107:567-74.
5. Litonjua AA, Gold DR. Asthma and obesity: common early life influences in the inception of disease. J Allergy Clin Immunol. 2008;121:1075-84.
6. Mattarese G, Moschos S, Mantzoros CS. Leptin in immunology. J Immunol. 2005;174:3137-42.
7. Visness CM, London SJ, Daniels JL, Kaufan JS, Yeatts DC, Riz AMS, et al. Association of obesity with IgE levels and allergy symtoms in children and adolescents: result from the national health and nutrition examination survey 2005âˆ’2006. J Allergy Clin Immunol. 2009;123:1163-9.
8. Tin FL, Kong APS, Chan HIS, Kai CC, Chung SH, Chan MHM. Association between obesity and atopy in Chinese school children. Int Arch Allergy Immnol. 2009;149:133-40.
9. Australian society of clinical immunology and allergy inc. Skin Prick Testing for the Diagnosis of allergic disease. Australia. 2006.
10. Setiabudiawan B, Kartasasmita CB. Risk factor of atopy in the first two years of life in Indonesian children. J All Clin Immunol. 2007;119:S126.
11. Fisher AA, Laing JE, Stoeckel JE, Townsend JW, editors. Handbook for family planning operation research design. 5th ed. New York: Population Council; 1998.
12. Kay AB. Allergy and allergic diseases. N Eng J Med. 2001;344:30-7.
13. Murphy K, Travers P, Walport M, editors. Janewayâ€™s immunobiology. 7th ed. New York: Garland Science; 2008.
14. Mattarese G, Moschos S, Mantzoros CS. Leptin in immunology. J Immunol. 2005;174:3137-42.
15. Yiannakouris N, Yannakoulia M, Melistas L, Chan JL, Klimis-Zacas D, Mantzoros CS. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. Clin Endoc Metab. 2001;86:4434-9.
16. Ramadhinara A, Widia F, Soegondo S, Setiawati A. The role of SOCS-3 in leptin resistance and obesity. Acta Med Indones. 2008;40:89-95.
17. Julia M, Weisenbruch MM, Delemarre DWHA, Surjono A. Influence of socioeconomic status on the prevalence of stunted growth and obesity in prepubertal Indonesian children. Food Nutr Bull. 2004;25:354-60.
18. Koning H, Baert MRM, Oranje AP, Savelkoul HFJ, Neijems HJ. Development of immune factors related to allergic mechanism in young children. Ped Res.1996;40:363-75.
19. Hallstrand TS, Fischer ME, Wurfel MM, Afari N, Buchwald D, Goldberg J. Genetic pleiotropy between asthma and obesity in a community-based samples of twins. J Allergy Clin Immunol. 2007;116:1235-41.
20. Eldin LB, Algamal HA, El-Dory GF, Rashad M, Arab SE, Al-ella NAA, et al. Relation between obesity, lipid profile, leptin, and atopic disorder in children. Egypt J Pediatr Immunol. 2008;6:27-34.
21. Davidson R, Roberts SE, Wotton CJ, Goldcare MJ. Influence of maternal and perinatal factors on subsequent hospitalisation for asthma in children: evidence from the Oxford record linkage study. BMC Pulmonary Med. 2010;10:14-22.
22. Savelkoul HFJ, Neijens HJ. Immune responses during allergic sensitization and the development of atopy. Allergy. 2000;55:989-97.
23. Matheson MC, Ballasuriya A, Wharton CL, Walters H, Dharmage SC. Breast-feeding and atopy disease: a cohort study from childhood to middle age. J Allergy Clin Immunol. 2007;120:1051-7.