Risk factors for positive tuberculin tests in children

  • Purnomo Sidhi Department of Child Health, Diponegoro University Medical School/Dr. Kariadi Hospital, Semarang, Central Java
  • Dwi Wastoro Dadiyanto Department of Child Health, Diponegoro University Medical School/Dr. Kariadi Hospital, Semarang, Central Java
  • Suhartono Suhartono Faculty of Public Health, Diponegoro University, Semarang, Central Java
DOI: https://doi.org/10.14238/pi51.6.2011.311-5
Keywords: tuberculosis contact, tuberculin test, children

Abstract

Background Tuberculosis (TB) is a chronic infectious disease and a public health problem. The World Health Organization (WHO) declared TB to be a global emergency because of currently increasing rates of disease and drug resistance. Two million people die annually because of TB. Children are one of the highest groups at risk for TB infection. An effort to define risk factors is needed for effective intervention.

Objective To identify risk factors for positive tuberculin tests in children.

Methods This case control study was done in elementary school children aged 8–12 years in areas served by three community health centers in Semarang. Twenty-nine subjects were Mantoux positive and 29 others served as controls. Consecutive sampling was used for all negative Mantoux test results. Pulmonary TB was diagnosed using the TB scoring system, including the Mantoux test. Statistical bivariate and multivariate analyses were performed.

Results History of household TB contact as a risk factor for positive tuberculin test in children resulted in an OROR of 3.76 (95% CI 1.059 to 13.342), P=0.040. History of illness at the time of testing resulted in an OR of 10.23 (95% CI 1.138 to 91.930), P=0.038. The probability of positive tuberculin testing was 90.7% if both these variables were positive.

Conclusion History of household TB contact and the history of illness at the time of testing were risk factors for positive tuberculin tests in children.

References

1. Rahajoe NN, Basir D, Makmuri MS, Kartasasmita CB. Pedoman nasional tuberculosis anak. 2nd ed. Jakarta: Respirology Division Indonesian Pediatric Society; 2007. p. 3-34
2. World Health Organization. Global tuberculosis control. Surveillance, planning, financing. 2002 [cited 2006 Oct 18]. Available from: http://www.who.int/ gtb/publications/globrep
3. Kabra SK, Lodha, Seth V. Some current concepts on childhood tuberculosis. Indian J Med Res. 2004;120:387-97.
4. Munoz FM, Starke JR. Tuberculosis (Mycobacterium tuberculosis). In: Behrman RE, Kliegman RM, Jenson HB, editors. Nelson textbook of pediatrics. 17th ed. Philadelphia: Saunders; 2004. p. 958-72.
5. Kebijakan nasional kolaborasi TB-HIV di Indonesia. In: Kolaborasi Subdit TB dengan Subdit AIDS & PMS Ditjen PP & PL. Salatiga: Ministry of Health of Indonesia; 2008. p. 7-23.
6. Kartasasmita BC, Basir D. Epidemiologi tuberculosis. In: Rahajoe NN, Supriyatno B, Setyanto DB, editors. Buku ajar respirologi anak. 1st ed. Jakarta: Indonesian Pediatric Society; 2008. p. 162-8.
7. Pertemuan sosialisasi survei tuberculin. Semarang: Provincial Health Office of Central Java; 2007. p. 5-18.
8. American Thoracic Society, Center for Disease Control and Prevention. Diagnostic standards and classification of tuberculosis in adults and children. Am J Respir Crit Care Med. 2000;161:1376-95.
9. Amdekar YK. Consensus statement of IAP working group: status report on diagnosis of childhood tuberculosis. Indian Pediatr. 2004;41:146-55.
10. Laporan pertemuan sosialisasi survei tuberkulin. Semarang: Provincial Health Office of Central Java; 2007. p. 3-17.
11. L Loprang F. Sosialisasi survei tuberkulin di Indonesia. Semarang: World Health Organization; 2007. p. 1-25.
12. Vijayasekaran D, Kumar RA, Gowrishankar NC, Nedunchelian K, Sethuraman S. Mantoux and contact positivity in tuberculosis. Indian J Pediatr. 2006;73:989-93.
13. Hypersensitivity and chronic inflammation. 2006 [cited 2005 Dec 23]. Available from: http://www.immuno.pdth.
com._ac.uk/~immuno/part1/lec13/lec13_ 97.html
14. Oemijati S, Samsudin, Assin MS, Tamaela LA, Nasar SS. Penerapan etika penelitian kedokteran. In: Sastroasmoro S, Ismael S, editors. Dasar-dasar metodologi penelitian klinis. 2nd ed. Jakarta: Indonesian Pediatric Society Publishing House; 2002. p. 288-93.
15. Musadad A. Penelitian hubungan faktor lingkungan rumah dengan kejadian TB paru di lingkungan rumah tangga. CDK. 2003. p.63.
Published
2011-12-31
How to Cite
1.
Sidhi P, Dadiyanto D, Suhartono S. Risk factors for positive tuberculin tests in children. PI [Internet]. 31Dec.2011 [cited 26Apr.2024];51(6):311-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/856
Issue
Vol 51 No 6 (2011): November 2011
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Articles

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Received 2016-10-11
Accepted 2016-10-11
Published 2011-12-31