Intestinal permeability of autistic and healthy children as measured by D-xylose test
Keywords:
Autistic disorder, intestinal permeability, oral d-xylose test, gastrointestinal disorders
Abstract
Background The etiopathogenesis of autistic disorder is unknown.Some authors suggest that food peptides may reach the central
nervous system through a defect of intestinal permeability and pro-
duce toxic effects resulting in behavior impairment.
Objectives To investigate the prevalence of increased intestinal
permeability in children with autistic disorder using oral D-xylose
test.
Method A cross-sectional study was conducted on 27 children
with autistic disorder and 54 healthy children (27 siblings and 27
unrelated children matching with those of the autistic group). The
subjects underwent oral D-xylose test. Subjects were free from
fever, drugs, and diarrhea. Student t-test and chi-square were used
for statistical analysis.
Results Prevalence of increased intestinal permeability in the au-
tistic group was 63%, which proved to be significant (P=0.007,
95%CI: -0.931; -0.987) compared to controls.
Conclusion The intestinal permeability significantly increased in
autistic children
References
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xylose absorption status of children in Bangladesh to
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veloping countries. WHO Bull 1976;54:485-94.
10. O’Boyle CJ, Mac Fie J, Dave K, Sagar PS, Poon P,
Mictchell CJ. Alterations in intestinal barrier func-
tion do not predispose to translocation of enteral bac-
teria in gastroenterological patients. Nutrition
1998;14:358-62.
11. Rolles CJ, Kendall MJ Nutter S, Anderson CM. One-
hour blood-xylose screening-test for celiac disease. Lan-
cet 1973;10:1043-5.
12. Morin CL, Buts JP, Weber A. One-hour blood-xylose
test in diagnosis of cows milk protein intolerance. Lan-
cet 1979;1(8126):1102-4.
13. Schaad U, Gaze H, Hadorn B. Value of 1-hour blood-
xylose test in diagnosis of childhood coeliac disease.
Arch Dis Child 1978;53:420-2.
14. Christie DL. Use of the one-hour blood xylose test as
an indicator of small bowel mucosal disease. Pediatrics
1978;92:725-8.
15. Levine JJ, Seidman E, Walker WA. Screening tests for
enteropathy in children. AJDC 1985;14:435-8.
Edminson PD, Braestrup CB, et al. Biologically active
peptide-containing fractions in schizophrenia and
childhood autism. Adv Biochem Psychopharmacol
1981;28;627-43.
2. D’Eufemia P, Celli M, Finocchiaro R. Abnormal intes-
tinal permeability in children with autism. Acta Pediatr
1996;85:1076-9.
3. Horvath K, Papadimitriou JC, Rabsztyn A, Dranchenberg
C, Tildon JT. Gastrointestinal abnormalities in children
with autistic disorder. J Pediatr 1999;135:559-63.
4. Lanzkowsky P, Lloyd EA, Lahey ME. The oral D-xy-
lose test in healthy infants and children. JAMA 1963;
186:163-5.
5. Craig RM, Atkinson AJ. D-xylose testing: A review.
Gastroenterology 1988;95:223-31.
6. Roe JH, Rice EW. A method for the determination of
free pentoses in animal tissues. J Biol Chem 1948;173:
507-12.
7. Burke V, Charlotte MA, Dodge JA, Gracey M, Grove
DI, Hadorn HB. Investigations and methodology. In:
Gracey M, Burke V, editors. Pediatric gastroenterology
and hepatology. 3rd ed. Boston: Blackwell Scientific
Publications; 1993. p. 1080 – 92.
8. Brown KH, Khatun M, Ahmad G. Relationship of the
xylose absorption status of children in Bangladesh to
their absorption of macronutrients from local diets. Am
J Clin Nutr 1981;34:1540-7.
9. Baker SJ. Subclinical intestinal malabsorption in de-
veloping countries. WHO Bull 1976;54:485-94.
10. O’Boyle CJ, Mac Fie J, Dave K, Sagar PS, Poon P,
Mictchell CJ. Alterations in intestinal barrier func-
tion do not predispose to translocation of enteral bac-
teria in gastroenterological patients. Nutrition
1998;14:358-62.
11. Rolles CJ, Kendall MJ Nutter S, Anderson CM. One-
hour blood-xylose screening-test for celiac disease. Lan-
cet 1973;10:1043-5.
12. Morin CL, Buts JP, Weber A. One-hour blood-xylose
test in diagnosis of cows milk protein intolerance. Lan-
cet 1979;1(8126):1102-4.
13. Schaad U, Gaze H, Hadorn B. Value of 1-hour blood-
xylose test in diagnosis of childhood coeliac disease.
Arch Dis Child 1978;53:420-2.
14. Christie DL. Use of the one-hour blood xylose test as
an indicator of small bowel mucosal disease. Pediatrics
1978;92:725-8.
15. Levine JJ, Seidman E, Walker WA. Screening tests for
enteropathy in children. AJDC 1985;14:435-8.
Published
2016-10-18
How to Cite
1.
Pusponegoro H, Rahayu T, Firmansyah A. Intestinal permeability of autistic and healthy children as measured by D-xylose test. PI [Internet]. 18Oct.2016 [cited 24Apr.2024];46(1):37-0. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/852
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Received 2016-10-10
Accepted 2016-10-10
Published 2016-10-18
Accepted 2016-10-10
Published 2016-10-18
