Thyroxine and thyroid stimulating hormone levels in under-five severe malnourished children

  • Shelvi H. Tamzil
  • Ryadi Fadil
  • Diet S. Rustama
  • Melinda D. Nataprawira
Keywords: thyroxine, thyroid stimulating hormone, proteinenergy malnutrition

Abstract

Background In Indonesia, protein energy malnutrition (PEM) in
children is still a health problem. Malnourished children will have
growth and development disruption, which is not only caused by
nutritional factor, but might be associated with endocrine system,
such as thyroid hormone metabolism. Hypothyroidism or thyroid
hypofunction could be happened in malnourished children.
Objective The purpose of this study was to assess thyroxine (T4)
and thyroid stimulating hormone (TSH) levels in under-five severe
malnourished children.
Methods This was a descriptive study with cross sectional design.
Subjects were all under-five severe malnourished children
based on nutritional evaluation in August 2001 done by local health
care workers in Andir District, Bandung. Severe malnutrition was
defined as weight for age less than -3SD (W/A <-3SD).
Results There were 42 subjects who fulfilled inclusion criteria, aged
11-57 months, five of them showed clinical manifestation of marasmus.
The T4 levels of the 41 subjects were still in normal limits
and within the range of 4.5-11.2 mg/dl. Thirty-nine subjects had
normal TSH levels, ranged from 0.9 to 5.0 mlU/ml, and 2 subjects
showed increased TSH levels of 6.8 and 7.6 mlU/ml, respectively.
Reduced T4 and TSH levels of 3.93 mg/dl and 0.2 mlU/ml, respectively
were detected in one subject
Conclusion In general, the T4 & TSH levels were still normal,
with only one subject (2%) showed low levels of T4 & TSH.

Author Biographies

Shelvi H. Tamzil
Department of Child Health, Medical School, Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Ryadi Fadil
Department of Child Health, Medical School, Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Diet S. Rustama
Department of Child Health, Medical School, Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Melinda D. Nataprawira
Department of Child Health, Medical School, Padjadjaran University, Hasan Sadikin Hospital, Bandung.

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Published
2016-10-10
How to Cite
1.
Tamzil S, Fadil R, Rustama D, Nataprawira M. Thyroxine and thyroid stimulating hormone levels in under-five severe malnourished children. PI [Internet]. 10Oct.2016 [cited 22May2024];43(2):42-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/837
Section
Articles
Received 2016-10-10
Accepted 2016-10-10
Published 2016-10-10