Nutritional status changes in children with malignant solid tumor before and after chemotherapy
Keywords:
nutritional status, anthropometrics, serum albumin, enteral feeding, malignant solid tumor, chemotherapy
Abstract
Background Although aggressive multimodal treatment programsin childhood cancer have significantly increased survival rates, the
morbidity caused by protein energy malnutrition related to therapy
is still high.
Objective To describe nutritional status changes in children with
malignant solid tumors after 21 days of chemotherapy.
Methods A descriptive prospective study with pre- and post-test
design in children with malignant solid tumors was conducted in
the Department of Child Health, Medical School University of In-
donesia/Cipto Mangunkusumo Hospital, Jakarta between Janu-
ary and July 2004. Anthropometrics (body weight, BW and mid-
upper-arm circumference, MUAC) and serum albumin measure-
ments were performed before and after 21 days of chemotherapy.
Results Twenty-two children were enrolled in this study. After 21
days of chemotherapy, 8 children had decreased BW and 6 chil-
dren had decreased MUAC, but 3 children gained weight and had
increased MUAC. Based on MUAC-for-age, 7 children had de-
creased nutritional status. Fifteen children had reduced serum al-
bumin levels based on a 10% cut-off point. The number of children
who had reduced serum albumin was larger than those who had
reduced BW and MUAC. In the evaluation of average oral food
consumption during 21 days, 7 out of 16 children could accept
more than 2/3 portion of served food. All of the children who re-
ceived enteral feeding could accept more than 2/3 portion of served
food.
Conclusion There was a decrease of nutritional status, BW,
MUAC, and serum albumin in most of the subjects after chemo-
therapy. Serum albumin level measurement was the more sensi-
tive parameter in determining nutritional status changes. Enteral
feeding seems more appropriate to fulfill nutritional needs than oral
feeding
References
1. Donaldson SS. Effects of therapy on nutritional status
of pediatric cancer patient. Cancer Res 1982;42
Suppl:729-36.
2. van Eys J. Malnutrition in children with cancer: Inci-
dence and consequence. Cancer 1979;43:2030-5.
3. Coates TD, Rickard KA, Grosfeld JL, Weetman RM.
Nutritional support of children with neoplastic diseases.
Surg Clin North Am 1986;66:1197-212.
4. Rickard KA, Baehner RL, Coates TD, Weetman RM,
Provisor AJ, Grosfeld JL. Supportive nutritional inter-
vention in pediatric cancer. Cancer Res 1982;42
Suppl:766-73.
5. Rickard KA, Detamore CM, Coates TD, Grosfeld JL,
Weetman RM, White NM, et al. Effect of nutrition
staging on treatment delays and outcome in stage IV
neuroblastoma. Cancer 1983;52:587-98.
6. Meguid MM, Laviano A. Weight loss and cachexia.
In: Abeloff MD, Armitage JO, Lichter AS, Niederhuber
JE, editors. Clinical Oncology. 2 nd ed. New York:
Churchill Livingstone; 2000. p. 579-96.
7. Allan WW, Hendricks KM. Manual of pediatric nutri-
tion. Philadelphia: WB Saunders; 1985. p. 1-51.
8. Mechanick JI, Brett EM. Nutrition support of the
chronically critically ill patient. Crit Care Clin
2002;18:597-618.
9. Gibson RS. Nutritional assessment, a laboratory
manual. New York: Oxford University Press; 1993. p.
127-42.
10. van Eys J. Effect of nutritional status on response to
therapy. Cancer Res 1982;42 Suppl:747-53.
11. Weinsier RL, Hunker HM, Krumdieck CL, Butterworth
CE. Hospital malnutrition: a prospective evaluation
of general medical patients during the course of hospi-
talization. Am J Clin Nutr 1979;32:418-26.
12. Rickard KA, Coates TD, Grosfeld JL, Weetman RM,
Baehner RL. The value of nutrition support in chil-
dren with cancer. Cancer 1986;58:1904-10.
13. Fernbach DJ, Vietti TJ. General aspects of childhood
cancer. In: Fernbach DJ, Vietti TJ, editors. Clinical pe-
diatric oncology. 4 th ed. St Louis: Mosby; 1991. p. 1-9.
14. Stiller CA, Draper GJ. The epidemiology of cancer in
children. In: Voute PA, Kalifa C, Barrett A, editors.
Cancer in children clinical management. 4 th ed. New
York: Oxford University Press; 1998. p. 1-19.
15. Kupfer GM. Childhood cancer, epidemiology. [cited
2001October 3 rd ] Available from: URL: http//
www.emedicine.com/ped/topic.
16. Buzby GP, Mullen JL. Nutritional assessment. In:
Rombeau JL, Caldwell MD, editors. Enteral and tube
feeding. Philadelphia: WB Saunders; 1984. p. 127-44.
17. Rickard KA, Grosfeld JL, Kirksey A, Ballantine TV,
Baehner RL. Reversal of protein-energy malnutrition
in children during treatment of advanced neoplastic
disease. Ann Surg 1979;190:771-81.
of pediatric cancer patient. Cancer Res 1982;42
Suppl:729-36.
2. van Eys J. Malnutrition in children with cancer: Inci-
dence and consequence. Cancer 1979;43:2030-5.
3. Coates TD, Rickard KA, Grosfeld JL, Weetman RM.
Nutritional support of children with neoplastic diseases.
Surg Clin North Am 1986;66:1197-212.
4. Rickard KA, Baehner RL, Coates TD, Weetman RM,
Provisor AJ, Grosfeld JL. Supportive nutritional inter-
vention in pediatric cancer. Cancer Res 1982;42
Suppl:766-73.
5. Rickard KA, Detamore CM, Coates TD, Grosfeld JL,
Weetman RM, White NM, et al. Effect of nutrition
staging on treatment delays and outcome in stage IV
neuroblastoma. Cancer 1983;52:587-98.
6. Meguid MM, Laviano A. Weight loss and cachexia.
In: Abeloff MD, Armitage JO, Lichter AS, Niederhuber
JE, editors. Clinical Oncology. 2 nd ed. New York:
Churchill Livingstone; 2000. p. 579-96.
7. Allan WW, Hendricks KM. Manual of pediatric nutri-
tion. Philadelphia: WB Saunders; 1985. p. 1-51.
8. Mechanick JI, Brett EM. Nutrition support of the
chronically critically ill patient. Crit Care Clin
2002;18:597-618.
9. Gibson RS. Nutritional assessment, a laboratory
manual. New York: Oxford University Press; 1993. p.
127-42.
10. van Eys J. Effect of nutritional status on response to
therapy. Cancer Res 1982;42 Suppl:747-53.
11. Weinsier RL, Hunker HM, Krumdieck CL, Butterworth
CE. Hospital malnutrition: a prospective evaluation
of general medical patients during the course of hospi-
talization. Am J Clin Nutr 1979;32:418-26.
12. Rickard KA, Coates TD, Grosfeld JL, Weetman RM,
Baehner RL. The value of nutrition support in chil-
dren with cancer. Cancer 1986;58:1904-10.
13. Fernbach DJ, Vietti TJ. General aspects of childhood
cancer. In: Fernbach DJ, Vietti TJ, editors. Clinical pe-
diatric oncology. 4 th ed. St Louis: Mosby; 1991. p. 1-9.
14. Stiller CA, Draper GJ. The epidemiology of cancer in
children. In: Voute PA, Kalifa C, Barrett A, editors.
Cancer in children clinical management. 4 th ed. New
York: Oxford University Press; 1998. p. 1-19.
15. Kupfer GM. Childhood cancer, epidemiology. [cited
2001October 3 rd ] Available from: URL: http//
www.emedicine.com/ped/topic.
16. Buzby GP, Mullen JL. Nutritional assessment. In:
Rombeau JL, Caldwell MD, editors. Enteral and tube
feeding. Philadelphia: WB Saunders; 1984. p. 127-44.
17. Rickard KA, Grosfeld JL, Kirksey A, Ballantine TV,
Baehner RL. Reversal of protein-energy malnutrition
in children during treatment of advanced neoplastic
disease. Ann Surg 1979;190:771-81.
Published
2016-10-10
How to Cite
1.
Januar B, Nasar S, Suradi R, Abdulsalam M. Nutritional status changes in children with malignant solid tumor before and after chemotherapy. PI [Internet]. 10Oct.2016 [cited 19Apr.2024];45(4):166-0. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/830
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Received 2016-10-08
Accepted 2016-10-08
Published 2016-10-10
Accepted 2016-10-08
Published 2016-10-10
