Relationship between obesity and leptin serum among low socioeconomic primary school children aged 5-7 years

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Soenarto Soenarto
Helena Anneke Sendow-Tangkilisan


Background Obesity has become a major health problem globally, indicates as an epidemic problem by World Health Organization (WHO). Adiposity rebound period may represent critical period for the development of adiposity. Recent data suggest that, in industrialized countries, people of low socioeconomic group are more likely to be obese than their high socioeconomic counterparts. Level of serum leptin was reported to be higher in obese subjects. There has been lack of data regarding leptin serum level in Indonesian obese children.

Objective This study aimed to investigate leptin serum level in low socioeconomic obese children. 

Methods This was a cross sectional study perfonned in Tuminting District, Manado. Obesity was defined based on body mass index for Asia􀁇Pacific condition, i.e., grade I obesity (BMI 25/29.9 kg/ mL), grade II (BM] 30-40 kg/ml), and grade III (BM] > 40 kg/m2 Low socioeconomic status was detennined based on Government's program Cash Direct Aid Program. loBod sample was obtained from inclusion subjects, consisted of leptin serum.

Results Fifty􀁇two low socioeconomic obese children were eligible \\lith age ranged between 5 to 7 years. They were divided into grade ] obesity (43 or 82.7%), and grade II (9 or 17.3%). The lowest leptin blood level was 10,291 pg/mL, while the highest was 41,500 pg/dL. All girls had nonnal serum leptin level; in contrast all boys had increased serum leptin level. 

Conclusions Leprin level increased in those subjects whose BMI increased.

Article Details

How to Cite
Soenarto S, Sendow-Tangkilisan H. Relationship between obesity and leptin serum among low socioeconomic primary school children aged 5-7 years. PI [Internet]. 30Jun.2010 [cited 16Sep.2019];50(3):166-. Available from:
Received 2016-10-07
Accepted 2016-10-07
Published 2010-06-30


1. Williams CL, Gulli MT, Deckelbaum RJ. Prevention and treatment of childhood obesity. CUff Atheroscler Rep. 2001;3A86-97.
2. Prentice AM. The emerging epidemic of obesity in eveloping countries. Int J Epidemiol. 2006;35:93-9.
3. Dietz WHo Critical periods in childhood for the evelopment
of obesity. Am) Clin Nutr. 1994;59,955-9.
4. Wang Y. Cross􀁯national comparison of childhood obesity: the epidemic and the relationship between obesity and socioeconomic status. Int J Epidemiol. 2001;30:1129-36.
5. Danielzik S, Czerwinski􀁯Mast M, Langnase K, Dilba B, Muller MJ. Parental overweight, socioeconomic status and high birth weight are the major determinants of overweight and obsity in 5-7 year-old children: baseline data of the Kiel Obesity Prevention Study (KOPS). Int) Obes. 2004;28,1494-502.
6. Villa􀁯Caballero L, Caballero􀁯Solano V, Chavarrfa-Gamboa M, Linares􀁯Lomeli P, TOffes􀁯Valencia E, Medina-Santill:in R, et al. Obesity and socioeconomic status in children of Tijuana. Am) Prev Med. 2006;30,197-203.
7. Blomquist HK, Bergstrom E. Obesity in 4-year-old children more prevalent in girls and in municipalities with a low sosioeconomic level. Acta Paediatr. 2007;96:113-6.
8. Considine RY. Regulation of leptin production. Rev Endocr Metab Disord. 2001;2,357-63.
9. Paracchini V, Pedotti P, Taioli E. Genetics of leptin and obesity: a huge review. Am J Epidemiol. 2005;162:101-14. 10. Aroonparkmongkol S, Wacharasindhu S, Srivuthana S. Serum levels of leptin in obese Thai children. Chula Med J. 2005;49;694-9.
11. Venner AA, Lyon ME, Doyle􀁯Baker PK. Leptin: a potential biomarker for childhood obesity? Clin Biochem. 2006; 39,1047-56.
12. McMillen IC, Edwards L), Duffield ), Muhlhausler BS. Regulation of leptin synthesis and secretion before birth: implications for the early programming of adult obesity. Reproduction. 2006;131,415-27.
13. Steering Committee. The Asia􀁯Pacific perspective: redefining obesity and its treatment. Health communications Australia Pty limited publicaton, 2000; p. 2l.
14. Loke KY. Consequences of childhood and adolescent obesity. Asia Pac) Clin Nutr. 2002; 11 (suppl);702S-4S.
15. Mozaffari H, Nabaei B. Obesity and related risk factors. Indian J Pediatr. 2007;74,265-7.
16. Florentino RF, Villavieja GM, Lana RD. Dietary and physical activity of 8- to10-year-old urban school children in Manila,
Philippines. Food Nutr Bull. 2002;23,267-73.
17. Sahu A. Resistance to the satiety action of leptin following
chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide Y neurones.
J Neuroendocrinol. 2002;14,796-804.
18. Landt lv1, ParvinCA, Wong M. Leptinin cerebrospinal fluid from children: correlation v.ith plasma leptin, sexual pimorphism, and lack of protein binding. Cun Chem. 2000;46,854-8.
19. Singhal A, Farooqi IS, Cole TJ, O'Rahilly S, Fewtrell M, Kattenhorn M, et al. Influence of leptin on arterial distensibility. A novel link between obesity and cardiovascular disease. Circulaton. 2002;106:1919-24.
20. Saad MF, Riad-Gabtiel MG, Khan A, Sharma A, Michael R, Jinagouda SD, et al. Diurnal and ultradian rhytmicity of plasma leptin: effect of gender and adiposity. J Clin Endoctinol Metab. 1998;83A53-9.