Correlation between hyperbilirubinemia in term infants and developmental delay in 2-4 year-old children

  • Rocky Wilar Department of Child Health, Sam Ratulangi Univetsity Medical School/Prof. Dr. R. D. Kandou Hospital, Manado
  • Nurhayati Masloman Department of Child Health, Sam Ratulangi Univetsity Medical School/Prof. Dr. R. D. Kandou Hospital, Manado
  • Hesti Lestari Department of Child Health, Sam Ratulangi Univetsity Medical School/Prof. Dr. R. D. Kandou Hospital, Manado
  • William Stephenson Tjeng Department of Child Health, Sam Ratulangi Univetsity Medical School/Prof. Dr. R. D. Kandou Hospital, Manado
DOI: https://doi.org/10.14238/pi50.3.2010.154-8
Keywords: term infant, hyperbilirubinemia, developmental delayed

Abstract

Background Up to 50 percent of term newborns have clinical jaundice during the first week of life. Many infants with bilirubin encephalopathy were asymptomatic, but they show neurodevelopmental delay few years later. Toxic effect occurs if unbound unconjugated bilirubin penetrates blood brain barrier and causes neuronal death.

Objective To investigate the relationship between moderate hyperbilirubinemia in tenn infants and developmental delay in 2- 4 year-old children.

Methods A retrospective cohort study was performed using
medical record of infants born between 2006-2007 in Division of Neonatology Prof. R.D. Kandoll General Hospital, Manado. Data from the medical record consisted of weeks of gestation, birth weight, Apgar scores, diagnosis of sepsis, congenital anomalies. Tenn infants with appropriate weight for gestational age were visited at their home to undergo developmental screening by Denver II and Vineland Social Maturity Scale test.

Results Fifty one children enrolled in this study (26 children with hyperbilirubinemia and 25 without  hyperbilirubinemia) consisted of 27 boys and 24 girls. Most children were 24 - 29 months old (24/51). The results of Vineland Social Maturity Scale test showed 14 children had delayed social maturation (10 Mth history of  hyperbilirubinemia). Denver II screening found 11 children had delayed language skill (10 Mth history of hyperbilirubinemia), 1 child Mth hyperbilirubinemia had delayed fine motoric and language skill.

Conclusions T here is a relationship between moderate hyperbilirubinemia in tenn infants and developmental delay in 2 - 4 year old children.

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Published
2010-06-30
How to Cite
1.
Wilar R, Masloman N, Lestari H, Tjeng W. Correlation between hyperbilirubinemia in term infants and developmental delay in 2-4 year-old children. PI [Internet]. 30Jun.2010 [cited 23Dec.2024];50(3):154-. Available from: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/813
Issue
Vol 50 No 3 (2010): May 2010
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Articles

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Received 2016-10-06
Accepted 2016-10-06
Published 2010-06-30